62049-65-4Relevant articles and documents
CONTINUOUS FLOW SYNTHESIS OF IBUPROFEN
-
Paragraph 0018; 0020-0021; 0366; 0381-0384; 0388-0391, (2021/04/23)
This disclosure generally relates to methods of making ibuprofen, naproxen, and derivatives thereof. This disclosure also generally relates to compounds made by the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
MgCl2-accelerated addition of functionalized organozinc reagents to aldehydes, ketones, and carbon dioxide
Metzger, Albrecht,Bernhardt, Sebastian,Manolikakes, Georg,Knochel, Paul
supporting information; experimental part, p. 4665 - 4668 (2010/08/19)
Figure Presented Pump it up! The sluggish reactivity of organozinc reagents in additions to aldehydes, ketones, and CO2 can be increased by MgCl2, which is usually generated in the preparation of the zinc reagent. The direct reaction with CO2, in particular, opens an expeditious route to phenylacetic acid derivatives, as demonstrated in a short synthesis of ibuprofen (see scheme).
Synthesis of E-aryl ethenesulfonamides: A simple one-pot, two-step procedure from 1-hydroxy-1-arylalkanes
Aramini, Andrea,Cesta, Maria C.,Coniglio, Silvia,Bijani, Christian,Colagioia, Sandro,D'Elia, Valerio,Allegretti, Marcello
, p. 7911 - 7914 (2007/10/03)
The unusual reactivity of 1-phenyl-1-ethane-sulfonic acid in thionyl chloride was investigated. Mechanistic considerations led us to set up a new and efficient synthesis of E-arylethenesulfonamides starting from 1-hydroxy-1-arylalkanes. The easy availability of the starting materials and the straightforward, one-pot procedure make this process an attractive method for the preparation of these compounds currently largely employed in chemical and pharmaceutical fields.