623-84-7

Basic information

• Product Name: 1,2-Propyleneglycol diacetate
• Synonyms: 1,2-PROPYLENE GLYCOL DIACETATE;1,2-PROPANEDIOL DIACETATE;1,2-DIACETOXYPROPANE;DOWANOL (TM) PGDA;TIMTEC-BB SBB008331;PROPYLENE DIACETATE;PROPYLENE GLYCOL DIACETATE;PGDA
• CAS NO: 623-84-7
• Molecular Formula: C₇H₁₂O₄
• Molecular Weight: 160.17
• EINECS: 210-817-6
• Product Categories: Ethers;Hydrophobic Polymers;Materials Science;Polymer Science;Polymers;Propylene Glycol Oligomers
• Mol File: 623-84-7.mol
• Article Data: 26

Chemical Properties

• Melting Point: -31 °C
• Boiling Point: 191 °C(lit.)
• Flash Point: 187 °F
• Appearance: clear colourless liquid
• Density: 1.05 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.58mmHg at 25°C
• Refractive Index: n20/D 1.414(lit.)
• Storage Temp.: Store below +30°C.
• Solubility: 90g/l
• Explosive Limit: 2.8-12.7%(V)
• Water Solubility: 76g/L at 20℃
• BRN: 1768914
• CAS DataBase Reference: 1,2-Propyleneglycol diacetate(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Propyleneglycol diacetate(623-84-7)
• EPA Substance Registry System: 1,2-Propyleneglycol diacetate(623-84-7)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 2
• RTECS: TY4900000
• TSCA: Yes
• Hazardous Substances Data: 623-84-7(Hazardous Substances Data)

Usage

Chemical Properties

clear colourless liquid

Uses

Different sources of media describe the Uses of 623-84-7 differently. You can refer to the following data:
1. 1,2-Diacetoxypropane is used in preparation method of antibacterial thermoplastic resin compound and its application.
2. Propylene glycol diacetate may be used as an emulsifier, solubilizer or solvent in pharmaceuticals.

General Description

Propylene glycol diacetate is a non ionic water soluble surfactant.

Flammability and Explosibility

Nonflammable

Purification Methods

Wash the ester with aqueous NaHCO3 in the presence of solid NaCl, dry it with MgSO4 and fractionally distil it. [Beilstein 2 H 142, 2 II 156, 2 III 312, 2 IV 220.]

InChI:InChI=1/C7H12O4/c1-5(11-7(3)9)4-10-6(2)8/h5H,4H2,1-3H3/t5-/m0/s1

Synthetic route

propylene glycol (57-55-6) + acetyl chloride (75-36-5) → 1,2-diacetoxypropane (623-84-7)

Conditions	Yield
With aluminum oxide at 25℃; for 0.25h;	98%

propylene glycol (57-55-6) + acetic acid (64-19-7) → 1,2-diacetoxypropane (623-84-7)

Conditions	Yield
With methanesulfonic acid at 30 - 35℃; for 6h;	97%
With sulfonated charcoal In benzene for 6h; Heating;	95%
With cobalt(II) chloride at 80℃; for 15h;	92%
With phosphotungstic acid; pyridinium propyl sulfobetaine at 105℃; for 2h;
With sulfuric acid

propylene glycol (57-55-6) + ethyl acetate (141-78-6) → 1,2-diacetoxypropane (623-84-7)

Conditions	Yield
With aluminum oxide; monoaluminum phosphate at 77℃;	85%

propylene glycol (57-55-6) + acetic anhydride (108-24-7) → 2-hydroxypropyl acetate (627-69-0) + 1,2-diacetoxypropane (623-84-7)

Conditions	Yield
yttria-stabilized zirconia In acetonitrile at 40℃; for 10h;	A 76% B 10%
ZSM-35 zeolite In acetonitrile at 24.85℃; for 24h;

propylene glycol (57-55-6) + acetic anhydride (108-24-7) → 1,2-diacetoxypropane (623-84-7)

Conditions	Yield
With sulfuric acid for 0.25h; Heating;	70%

acetic anhydride (108-24-7) + methyloxirane (75-56-9, 16033-71-9) → 1,2-diacetoxypropane (623-84-7)

Conditions	Yield
With sulfuric acid at 20℃; for 20h;	49%

propylene glycol (57-55-6) + carbon dioxide (124-38-9) + acetonitrile (75-05-8) → acetamide (60-35-5) + 1,2-propylene cyclic carbonate (108-32-7) + propane-1,2-diol 2-monoacetate (6214-01-3) + 1,2-diacetoxypropane (623-84-7) + 1-(1-Hydroxy-ethoxy)-propan-2-ol

Conditions	Yield
With [Zn(methylenebis-3,5-dimethylpyrazole)2(CF3SO3)]+(CF3SO3)- at 135℃; under 3750.38 - 30003 Torr; for 16h; Catalytic behavior; Reagent/catalyst; Pressure; Autoclave;	A n/a B 37% C n/a D n/a E n/a

acetic anhydride (108-24-7) + poly(propylene oxide) → 1,2-diacetoxypropane (623-84-7)

Conditions	Yield
With zinc(II) triflate at 150℃; for 24h;	18%

Ketene (463-51-4) + propylene glycol (57-55-6) → 1,2-diacetoxypropane (623-84-7)

Conditions	Yield
With sulfuric acid

1,2-Dichloropropane (26198-63-0, 78-87-5) + sodium acetate (127-09-3) → 1,2-diacetoxypropane (623-84-7)

Conditions	Yield
With water

1,2-Dibromopropane (78-75-1) + potassium acetate (127-08-2) → 1,2-diacetoxypropane (623-84-7)

Conditions	Yield
With acetic acid

1,2-Dibromopropane (78-75-1) + silver(I) acetate (563-63-3) → 1,2-diacetoxypropane (623-84-7)

1,2-Dibromopropane (78-75-1) + potassium acetate (127-08-2) + acetic acid (64-19-7) → 1-bromo-1-propene (590-14-7) + 1,2-diacetoxypropane (623-84-7)

Allyl acetate (591-87-7) + acetic acid (64-19-7) → 1,2-diacetoxypropane (623-84-7)

Conditions	Yield
With sulfuric acid; iron(II) sulfate at 150 - 170℃;
at 280℃;
With sulfuric acid at 160 - 200℃;

acetic acid (64-19-7) + methyloxirane (75-56-9, 16033-71-9) → 1,2-diacetoxypropane (623-84-7)

Conditions	Yield
With sodium hydrogen sulfate
With sulfuric acid

1,2-propylene cyclic carbonate (108-32-7) + acetic anhydride (108-24-7) → 1,2-diacetoxypropane (623-84-7)

Conditions	Yield
With tetraethylammonium iodide at 135 - 140℃;

propylene glycol (57-55-6) → 1,2-diacetoxypropane (623-84-7) + acetic acid (64-19-7) + n, G=-CHMeCH2-

Conditions	Yield
With tin(IV) acetate In toluene for 3h; Product distribution; Heating;

Allyl acetate (591-87-7) + sulfuric acid (7664-93-9) + acetic acid (64-19-7) → 1,2-diacetoxypropane (623-84-7)

Conditions	Yield
at 160 - 200℃;

Allyl acetate (591-87-7) + iron(II) sulfate + acetic acid (64-19-7) → 1,2-diacetoxypropane (623-84-7)

Conditions	Yield
at 150 - 170℃;

2-ethoxy-1-propanol (19089-47-5) + sulfuric acid (7664-93-9) + acetic anhydride (108-24-7) → 1,2-diacetoxypropane (623-84-7) + ethyl acetate (141-78-6)

2-hydroxypropyl acetate (627-69-0) → 1,2-diacetoxypropane (623-84-7) + acetic acid (64-19-7) + allylal acetate + propenyl acetate

Conditions	Yield
at 525℃; an Glasoberflaechen;

cupric chloride + aluminum acetate (139-12-8) → 1,2-diacetoxypropane (623-84-7)

Conditions	Yield
With acetic anhydride In acetic acid

methyloxirane (75-56-9, 16033-71-9) → 2-methyl-[1,3]dioxane (626-68-6) + 2,2,4-trimethyl-1,3-dioxolane (1193-11-9, 116944-25-3) + 2-ethyl-4-methyl-1,3-dioxolane (4359-46-0) + 2-methyl-1,3-pentanediol (149-31-5) + 1-Propyl acetate (109-60-4) + prop-2-enyl propanoate (2408-20-0) + 1,2-diacetoxypropane (623-84-7) + carbon dioxide (124-38-9) + 2,5-dimethyl-1,4-dioxane (15176-21-3) + acetaldehyde (75-07-0) + allyl alcohol (107-18-6) + dimethylglyoxal (431-03-8) + 4-methyl-1,3-dioxolane (1072-47-5) + crotonaldehyde (123-73-9)

Conditions	Yield
With FeNi layered double hydroxide/graphene oxide at 210℃; for 0.0277778h; Catalytic behavior; Reagent/catalyst; Temperature; Wavelength; Flow reactor; Irradiation;

...Expand

1,2-diacetoxypropane (623-84-7) + saccharin (81-07-2) → C12H13NO5S

Conditions	Yield
With scandium tris(trifluoromethanesulfonate) at 150℃; for 24h; Sealed tube;	80%

1,2-diacetoxypropane (623-84-7) → Allyl acetate (591-87-7)

Conditions	Yield
at 470 - 500℃;
at 470 - 500℃;

1,2-diacetoxypropane (623-84-7) → Allyl acetate (591-87-7) + 1-propenyl acetate (3249-50-1)

Conditions	Yield
at 500℃; bei raschem Erhitzen;

1,2-diacetoxypropane (623-84-7) → acetic acid-(2-chloro-propyl ester) (627-68-9)

Conditions	Yield
With hydrogenchloride at 30 - 50℃;

1,2-diacetoxypropane (623-84-7) → propionaldehyde (123-38-6) + allyl alcohol (107-18-6)

Conditions	Yield
Pyrolysis.und Verseifung des erhaltenen Gemisches von Allylacetat und Propenylacetat mit verd.H2SO4;
at 500℃; Pyrolysis.und nachfolgende Hydrolyse, zunaechst mit verd.H2SO4, dann mit Natronlauge;

1,2-diacetoxypropane (623-84-7) + butan-1-ol (71-36-3) → acetic acid butyl ester (123-86-4)

Conditions	Yield
With hydrogenchloride at 150℃;

1,2-diacetoxypropane (623-84-7) → Allyl acetate (591-87-7) + acetic acid (64-19-7) + acrolein (107-02-8) + carbon monoxide

Conditions	Yield
at 500℃; Produkt5: Kohlenmonoxid.Pyrolysis;

Upstream product

• 463-51-4 Ketene 
• 57-55-6 propylene glycol 
• 26198-63-0 1,2-Dichloropropane 
• 127-09-3 sodium acetate 
• 78-75-1 1,2-Dibromopropane 
• 127-08-2 potassium acetate 
• 563-63-3 silver(I) acetate 
• 108-24-7 acetic anhydride 
• 64-19-7 acetic acid 
• 591-87-7 Allyl acetate 
• 75-56-9 methyloxirane 
• 108-32-7 1,2-propylene cyclic carbonate 
• 141-78-6 ethyl acetate 
• 627-69-0 2-hydroxypropyl acetate 

Downstream Products

• 591-87-7 Allyl acetate 
• 3249-50-1 1-propenyl acetate 
• 123-38-6 propionaldehyde 
• 107-18-6 allyl alcohol 
• 123-86-4 acetic acid butyl ester 
• 64-19-7 acetic acid 
• 107-02-8 acrolein 
• 79-21-0 peracetic acid 
• 57-55-6 propylene glycol 

Relevant articles and documents

A study on the cataluminescence of propylene oxide on FeNi layered double hydroxides/graphene oxide

In this work, FeNi layered double hydroxides/graphene oxide (FeNi LDH/GO) was prepared, which exhibits excellent selective cataluminescent performance towards propylene oxide. The selectivity and sensitivity of the cataluminescence (CTL) reaction were investigated in detail. Moreover, the catalytic reaction mechanism, including the intermediate products and the conversion of reactants to products, was discussed based on both the experimental and computational results. Furthermore, the proposed FeNi LDH/GO based CTL sensor was successfully applied for the determination of propylene oxide residue in fumigated raisins, which indicates extensive application potential for rapid food safety evaluation.

Homogeneous and silica-supported zinc complexes for the synthesis of propylene carbonate from propane-1,2-diol and carbon dioxide

Three organozinc complexes have been synthesised and found to catalyse the carbonylation of propylene glycol with carbon dioxide to form propylene carbonate. A similar tethered organozinc complex was supported onto high loading aminopropyl functionalised hexagonal mesoporous silica and was also found to be catalytically active.

Zinc-catalyzed depolymerization of polyethers to produce valuable building blocks

The recycling of polymers continues to be a significant matter for a sustainable society. In particular, the conversion of end-of-life polymers to monomers or suitable low-molecular weight chemicals creates a feedstock for new high-quality polymeric materials and contributes to conserve resources and allow overall an efficient waste-managing system. In the present study, we have set up a straightforward methodology for the depolymerization of artificial polyethers applying cheap and abundant zinc( II) salts as precatalysts. In the presence of bio-based fatty acid chlorides as depolymerization reagent well-defined chloroesters were accessible in good to excellent yields. Moreover, acetic anhydride and fatty acids were applied as depolymerization reagents resulting in the formation of diacetates in moderate yields. In both cases the obtained products (chloroesters, diacetates) can be useful building blocks in polymerization chemistry. Noteworthy, overall a recycling of polyethers are possible. Springer Science+Business Media New York 2014.