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646995-35-9

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646995-35-9 Usage

Biochem/physiol Actions

Cinaciguat activates sGC (soluble guanylate cyclase) independently of NO. Cinaciguat binds to sGC′s NO-sensory H-NOX domain when it is heme-depleted. Also, the compound Cinaciguat protects sGC from oxidation-induced ubiquitin-triggered degradation.

Check Digit Verification of cas no

The CAS Registry Mumber 646995-35-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,4,6,9,9 and 5 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 646995-35:
(8*6)+(7*4)+(6*6)+(5*9)+(4*9)+(3*5)+(2*3)+(1*5)=219
219 % 10 = 9
So 646995-35-9 is a valid CAS Registry Number.

646995-35-9 Well-known Company Product Price

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  • Sigma

  • (SML1532)  Cinaciguat hydrochloride  ≥98% (HPLC)

  • 646995-35-9

  • SML1532-5MG

  • 2,228.85CNY

  • Detail
  • Sigma

  • (SML1532)  Cinaciguat hydrochloride  ≥98% (HPLC)

  • 646995-35-9

  • SML1532-25MG

  • 8,950.50CNY

  • Detail

646995-35-9Downstream Products

646995-35-9Relevant articles and documents

Insights into soluble guanylyl cyclase activation derived from improved heme-mimetics

Von Wantoch Rekowski, Margarete,Kumar, Vijay,Zhou, Zongmin,Moschner, Johann,Marazioti, Antonia,Bantzi, Marina,Spyroulias, Georgios A.,Van Den Akker, Focco,Giannis, Athanassios,Papapetropoulos, Andreas

, p. 8948 - 8952 (2013/12/04)

Recently, the structure of BAY 58-2667 bound to the Nostoc sp. H-NOX domain was published. On the basis of this structural information, we designed BAY 58-2667 derivatives and tested their effects on soluble guanylyl cyclase (sGC) activity. Derivative 20 activated sGC 4.8-fold more than BAY 58-2667. Co-crystallization of 20 with the Ns H-NOX domain revealed that the increased conformational distortion at the C-terminal region of αF helix containing 110-114 residues contributes to the higher activation triggered by 20.

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