66158-68-7

Basic information

• Product Name: 1-((S)-2-HydroxyMethyl-pyrrolidin-1-yl)-ethanone
• Synonyms: 1-((S)-2-HydroxyMethyl-pyrrolidin-1-yl)-ethanone;1-[(2S)-2-(hydroxyMethyl)-1-pyrrolidinyl]-Ethanone;(S)-1-(2-(hydroxymethyl)pyrrolidin-1-yl)ethanone
• CAS NO: 66158-68-7
• Molecular Formula: C₇H₁₃NO₂
• Molecular Weight: 143.18362
• Mol File: 66158-68-7.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-((S)-2-HydroxyMethyl-pyrrolidin-1-yl)-ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-((S)-2-HydroxyMethyl-pyrrolidin-1-yl)-ethanone(66158-68-7)
• EPA Substance Registry System: 1-((S)-2-HydroxyMethyl-pyrrolidin-1-yl)-ethanone(66158-68-7)

Safety Data

• Hazardous Substances Data: 66158-68-7(Hazardous Substances Data)

Usage

General Description

1-((S)-2-HydroxyMethyl-pyrrolidin-1-yl)-ethanone is a chemical compound with a molecular structure containing a pyrrolidine ring and a ketone group. It is a chiral compound, meaning it has an asymmetrical carbon atom, which gives it two enantiomeric forms. This chemical is commonly used as a reagent in various chemical reactions and synthesis processes due to its unique structure and reactivity. It can also be utilized as a building block in the production of pharmaceuticals and agrochemicals. Additionally, it has potential applications in the field of materials science and as a precursor in organic synthesis.

Upstream product

• 2033-24-1 cycl-isopropylidene malonate 
• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 
• 147-85-3 L-proline 
• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 

Downstream Products

• 509151-90-0 1-[(S)-2-(2,4-Dinitro-phenoxymethyl)-pyrrolidin-1-yl]-ethanone 
• 852324-30-2 (R)-1-acetylpyrrolidine-2-carbaldehyde 
• 3326-13-4 N-acetyl-2-piperidone 
• 133129-46-1 (R)-N-((S)-1-Ethyl-pyrrolidin-2-ylmethyl)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionamide 
• 133129-42-7 (S)-2,3-dimethoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(3-fluoropropyl)-6-hydroxybenzamide 
• 133129-40-5 (S)-2,3-dimethoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(2-fluoroethyl)benzamide 
• 133129-44-9 (S)-2,3-dimethoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(2-fluoroethyl)-6-hydroxybenzamide 
• 126247-33-4 FPMP 
• 133129-45-0 (S)-2,3-dimethoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-propylbenzamide 
• 101460-48-4 (S)-5,6-dimethoxy-N-<(1-ethyl-2-pyrrolidinyl)methyl>-3-propylsalicylamide 
• 22795-99-9 (S)-2-(Aminomethyl)-1-ethylpyrrolidine 
• 88422-19-9 (S)-(-)-1-(4-Nitrophenyl)-2-pyrrolidinemethanol 
• 7754-77-0 N-2,4-Dinitrophenyl-L-prolinol 
• 73323-64-5 (S)-1-acetylpyrrolidine-2-carbaldehyde 

Relevant articles and documents

Environmentally benign decarboxylative: N-, O-, and S-Acetylations and acylations

An operationally simple and general method for acetylation and acylation of a wide variety of substrates (amines, alcohols, phenols, thiols, and hydrazones) has been reported. Meldrum's acid and its derivatives have been used as an air-stable, non-volatile, cost-effective, and easy to handle acetylating/acylating agent. Easily separable byproducts (CO2 and acetone) allowed the isolation of analytically pure acetylated products without the requirement of work-up and any chromatography. This journal is

Synthesis of C2-symmetrical bis-β-amino alcohols and their application in the enantioselective addition of diethylzinc to aldehydes

The C2-symmetrical bis-β-amino alcohols 1-6 were prepared and especially attention is focused on bridges, which link the two β-amino alcohol units. These ligands have been applied as chiral catalysts in the asymmetric addition of diethylzinc to aldehydes. sec-Alcohols have been obtained in good yields with up to 95.4% enantiomeric excess.

Enantioselective epoxidation of unfunctionalized simple olefins by non-racemic molybdenum(VI)(oxo-diperoxo) complexes

Molybdenum(VI)(oxo-diperoxo) complexes bearing bidentate ligands with hydroxy and carbonyl functions show asymmetric induction in the stoichiometric epoxidation of simple prochiral olefins.The influence of the ligand and alkene structure on the enantiomeric excess of the oxiranes has been investigated.The addition of chiral diols to the molybdenum(VI)(oxo-diperoxo) reagents gives high enantiomeric excesses probably because of an efficient kinetic resolution of the oxiranes formed.