126247-33-4

Basic information

• Product Name: 5-fluoropropylepidepride
• Synonyms: 5-fluoropropylepidepride
• CAS NO: 126247-33-4
• Molecular Formula: C₁₉H₂₉FN₂O₃
• Molecular Weight: 352.4435632
• Mol File: 126247-33-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 441°C at 760 mmHg
• Flash Point: 220.5°C
• Appearance: /
• Density: 1.081g/cm³
• Vapor Pressure: 5.62E-08mmHg at 25°C
• Refractive Index: 1.506
• CAS DataBase Reference: 5-fluoropropylepidepride(CAS DataBase Reference)
• NIST Chemistry Reference: 5-fluoropropylepidepride(126247-33-4)
• EPA Substance Registry System: 5-fluoropropylepidepride(126247-33-4)

Safety Data

• Hazardous Substances Data: 126247-33-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C19H29FN2O3/c1-4-22-10-6-8-15(22)13-21-19(23)16-11-14(7-5-9-20)12-17(24-2)18(16)25-3/h11-12,15H,4-10,13H2,1-3H3,(H,21,23)

Upstream product

• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 
• 133129-47-2 2,3-dimethoxy-5-(2-propenyl)benzoic acid, methyl ester 
• 96619-89-5 3-methoxy-2-(2-propenyloxy)benzoic acid, methyl ester 
• 6342-70-7 3-methoxymethylsalicylate 
• 877-22-5 3-methoxysalicylic acid 
• 22795-99-9 (S)-2-(Aminomethyl)-1-ethylpyrrolidine 
• 136565-41-8 5-(3-Fluoro-propyl)-2,3-dimethoxy-benzoyl chloride 
• 66158-71-2 (S)-1-acetyl-2-(azidomethyl)pyrrolidine 
• 66158-70-1 (S)-1-acetyl-2-(chloromethyl)pyrrolidine 
• 66158-68-7 (S)-1-(2-(hydroxymethyl) pyrrolidin-1-yl)ethanone 
• 133129-49-4 2,3-dimethoxy-5-<3-<<(4-methylphenyl)sulfonyl>oxy>propyl>benzoic acid, methyl ester 
• 133129-51-8 2,3-dimethoxy-5-(fluoropropyl)benzoic acid 

Relevant articles and documents

Synthesis and in vitro evaluation of 2,3-dimethoxy-5-(fluoroalkyl)-substituted benzamides: High-affinity ligands for CNS dopamine D2 receptors

A number of 2,3-dimethoxy-5-(fluoroalkyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl] benzamides (with or without a 6-hydroxy group) were synthesized and evaluated as dopamine D2 receptor ligands. The parent acids were synthesized via the Claisen rearrangement of the appropriate O-allyl ethers, which were derived from o-vanillic acid or 2,3-dimethoxysalicylic acid. A decrease in reactivity was found to be characteristic of pentasubstituted benzoates, and difficulties were encountered with the introduction of fluorine onto the ethyl side chains. The (fluoroethyl)- and (fluoropropyl)salicylamides were 5 times more potent than the corresponding benzamides in inhibiting [3H]spiperone binding to the D2 receptor. These (fluoroalkyl)salicylamides are of potential value for in vivo positron emission tomography (PET) studies upon the basis of their relatively selective, high potency binding affinity for the D2 receptor.