66275-61-4

Basic information

• Product Name: N-chloro-N'-p-tolylbenzamidine
• Synonyms: N-chloro-N'-p-tolylbenzamidine
• CAS NO: 66275-61-4
• Molecular Weight: 244.724
• Mol File: 66275-61-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-chloro-N'-p-tolylbenzamidine(CAS DataBase Reference)
• NIST Chemistry Reference: N-chloro-N'-p-tolylbenzamidine(66275-61-4)
• EPA Substance Registry System: N-chloro-N'-p-tolylbenzamidine(66275-61-4)

Safety Data

• Hazardous Substances Data: 66275-61-4(Hazardous Substances Data)

Upstream product

• 1859-00-3 N'-(4-methyphenyl)benzamidine 
• 1859-00-3 N-(4-methylphenyl)benzamidine 

Downstream Products

• 71316-14-8 N'-(4-methylphenyl)-N-(triphenylphosphoranylidene)-benzenecarboximidamide 
• 120422-03-9 2,5-Diphenyl-3-p-tolyl-3,5-dihydro-imidazol-4-one 
• 1859-00-3 N-(4-methylphenyl)benzamidine 
• 179805-95-9 5-chloro-1-(4'-methylphenyl)-4-morpholino-2-phenylimidazole 
• 2963-65-7 6-methyl-2-phenyl-1H-benzo[d]imidazole 
• 128256-23-5 6-methyl-4-(4'-nitrophenyl)-2-phenylquinazoline 
• 128256-24-6 6-Methyl-4-(2-nitro-phenyl)-2-phenyl-quinazoline 
• 128256-20-2 6-Methyl-4-phenethyl-2-phenyl-3,4-dihydro-quinazoline 
• 128256-18-8 4-Hexyl-6-methyl-2-phenyl-3,4-dihydro-quinazoline 
• 128256-21-3 6-Methyl-4-phenethyl-2-phenyl-quinazoline 
• 128256-19-9 4-Hexyl-6-methyl-2-phenyl-quinazoline 
• 128256-25-7 6-Methyl-4-(2'-aminophenyl)-2-phenylquinazoline 
• 128256-26-8 6-Methyl-4-pentyl-2-phenyl-quinazoline 
• 128256-22-4 6-Methyl-2,4-diphenyl-3,4-dihydro-quinazoline 

Relevant articles and documents

N-chlorosuccinimide/sodium hydroxide-mediated synthesis of benzimidazoles from amidines under mild conditions

A convenient room-temperature one-pot procedure for the preparation of benzimidazoles derivatives from N-arylamidines has been developed. The reaction of N-aryl-N'-chloro amidines, generated by the treatment of N-arylamidines with N-chlorosuccinimide, in presence of sodium hydroxide provides benzimidazoles in good to excellent yields. Nitrogen anion generated in situ from succinimide (by-product of the chlorination step using NCS) and hydroxide anion was found to be highly effective as Bronsted base to promote the cyclization into benzimidazole of N-aryl-N'-chloroamidine.

REACTION OF N-CHLORO-N'-ARYLBENZAMIDINES WITH SULFUR DICHLORIDE. 1-CHLORO-3-R-1,2,4-BENZOTHIADIAZINES

1-Chloro-3-R-1,2,4-benzothiadiazines are produced in the reaction of N-chloro-N'-arylbenzamidines with sulfur dichloride in the presence of pyridine.During hydrolysis they are converted into 1-oxo-3-R-2H-1,2,4-benzothiadiazines, by the action of thiopheno