66985-47-5

Basic information

• Product Name: Benzeneacetonitrile, 2-chloro-a-[(trimethylsilyl)oxy]-
• CAS NO: 66985-47-5
• Molecular Formula: C11H14ClNOSi
• Molecular Weight: 239.777
• Mol File: 66985-47-5.mol
• Article Data: 35

Chemical Properties

• CAS DataBase Reference: Benzeneacetonitrile, 2-chloro-a-[(trimethylsilyl)oxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetonitrile, 2-chloro-a-[(trimethylsilyl)oxy]-(66985-47-5)
• EPA Substance Registry System: Benzeneacetonitrile, 2-chloro-a-[(trimethylsilyl)oxy]-(66985-47-5)

Safety Data

• Hazardous Substances Data: 66985-47-5(Hazardous Substances Data)

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 89-98-5 2-chloro-benzaldehyde 
• 177755-45-2 2-(3-fluoro-4-methoxyphenyl)-2-[(trimethylsilyl)oxy]acetonitrile 
• 7677-24-9 trimethylsilyl cyanide 
• 151-50-8 potassium cyanide 

Downstream Products

• 13312-84-0 2-chloromandelonitrile 
• 72867-72-2 1-(2-chlorophenyl)-2-phenyl-1-ethanone 
• 125803-35-2 2-acetoxy-2-(2-chlorophenyl)acetonitrile 
• 756846-54-5 2-(2-chlorophenyl)-2-fluoroacetonitrile 
• 52923-20-3 (S)-2-(2-chlorophenyl)-2-hydroxyacetonitrile 
• 121986-01-4 (R)-2-chloromandelonitrile 
• 6526-67-6 N,N-dimethyl-o-chlorobenzamide 
• 82128-86-7 5-(2-chlorophenyl)oxazolidine-2,4-dione 
• 2856-79-3 ethyl α-bromo-2-chlorophenylacetate 
• 40658-44-4 Benzylamino-(2-chloro-phenyl)-acetonitrile; hydrochloride 
• 93554-89-3 (2-Chloro-phenyl)-dimethylamino-acetonitrile; hydrochloride 
• 49704-74-7 Amino-(2-chloro-phenyl)-acetonitrile; hydrochloride 
• 83575-79-5 (2-Chloro-phenyl)-dimethylamino-trimethylsilanyloxy-acetonitrile 
• 87712-74-1 (R,R)-(+)-α-<(1-phenylethyl)amino>-α-(2-chlorophenyl)acetonitrile hydochloride 

Relevant articles and documents

Conjugated Bis-Guanidines (CBGs) as β-Diketimine Analogues: Synthesis, Characterization of CBGs/Their Lithium Salts and CBG Li Catalyzed Addition of B?H and TMSCN to Carbonyls

Herein, we report a range of conjugated bis-guanidines (CBGs) L [L={(ArHN)(ArHN)C=N?C=(NAr)(NHAr)}; Ar=2, 6-Me2 - C6H3, (1), 2, 4, 6-Me3?C6H2, (2), 2, 6-Et2?C6H3

Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain

The emerging pharmacological target soluble epoxide hydrolase (sEH) is a bifunctional enzyme exhibiting two different catalytic activities that are located in two distinct domains. Although the physiological role of the C-terminal hydrolase domain is well-investigated, little is known about its phosphatase activity, located in the N-terminal phosphatase domain of sEH (sEH-P). Herein we report the discovery and optimization of the first inhibitor of human and rat sEH-P that is applicable in vivo. X-ray structure analysis of the sEH phosphatase domain complexed with an inhibitor provides insights in the molecular basis of small-molecule sEH-P inhibition and helps to rationalize the structure-activity relationships. 4-(4-(3,4-Dichlorophenyl)-5-phenyloxazol-2-yl)butanoic acid (22b, SWE101) has an excellent pharmacokinetic and pharmacodynamic profile in rats and enables the investigation of the physiological and pathophysiological role of sEH-P in vivo.

Layered double hydroxides (LDHs): As efficient heterogeneous catalyst for the cyanosilylation of aromatic aldehydes

We report the first application of Layered Double Hydroxides (LDHs) as efficient and novel heterogeneous catalyst for the cyanosilylation of aldehydes with excellent yields and simple work up. The reaction between different aldehydes with electron-withdra