6855-64-7

Basic information

• Product Name: 5-Amino-2-phenylindole
• Synonyms: 5-Amino-2-phenylindole;2-phenyl-1H-indol-5-aMine
• CAS NO: 6855-64-7
• Molecular Formula: C₁₄H₁₂N₂
• Molecular Weight: 208.25848
• Mol File: 6855-64-7.mol
• Article Data: 10

Chemical Properties

• Melting Point: 231.5-233 °C(Solv: benzene (71-43-2))
• Boiling Point: 469.3±25.0 °C(Predicted)
• Appearance: /
• Density: 1.229±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 17.19±0.30(Predicted)
• CAS DataBase Reference: 5-Amino-2-phenylindole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Amino-2-phenylindole(6855-64-7)
• EPA Substance Registry System: 5-Amino-2-phenylindole(6855-64-7)

Safety Data

• Hazardous Substances Data: 6855-64-7(Hazardous Substances Data)

Usage

General Description

5-Amino-2-phenylindole is a chemical compound falling under the category of indoles. The indole unit is an important sanitary in both natural and synthetic chemistry. 5-Amino-2-phenylindole exhibits an aromatic organic structure consisting of a six-membered benzene ring fused to a five-membered nitrogen-containing pyrrole ring. 5-Amino-2-phenylindole, as suggested by its name, contains an amine group(-NH2) and phenyl group added to this basic structure. Though its specific applications vary, compounds in this class are often utilized in biochemical research and industry for the synthesis of dyes, pharmaceuticals, and pesticides. The specific properties, such as melting point, boiling point, and solubility of 5-Amino-2-phenylindole, can differ based on its interactions with other substances or changes in its physical state. As with any chemical compound, appropriate safety measures should be taken during its handling and storage.

Upstream product

• 857555-71-6 2-[2,5-bis-(dimethylsulfamoyl-amino)-phenyl]-3-oxo-3-phenyl-propionic acid ethyl ester 
• 4993-87-7 5-nitro-2-phenyl-1H-indole 
• 6293-83-0 2-iodo-4-nitrophenylamine 
• 536-74-3 phenylacetylene 
• 165280-21-7 4-nitro-2-(2-phenylethynyl)aniline 
• 108-86-1 bromobenzene 
• 1227410-09-4 2-boronic acid 1-N-BOC-5-(N',N'-bisBOC)aminoindole 
• 16720-35-7 N,N'-2,5-cyclohexadiene-1,4-diylidenebis 
• 500992-02-9 N-[(4'-nitro-2'-phenylethynyl)phenyl]butyramide 
• 120830-42-4 N,N'-[2-(1-benzoyl-2-oxo-2-phenyl-ethyl)-p-phenylene]-bis-benzamide 

Downstream Products

• 4771-09-9 N-(2-phenyl-1H-indol-5-yl)acetamide 
• 748799-38-4 4,4,4-trifluoro-3-oxobutyric acid N-(2-phenyl-1H-5-indolyl)amide 

Relevant articles and documents

Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases

The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.

COMPOSITIONS FOR TREATMENT OF CYSTIC FIBROSIS AND OTHER CHRONIC DISEASES

The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.

Straightforward selective preparation of nitro- or amino-indoles from 2-halonitroanilines and alkynes. First synthesis of 7-amino-5-nitroindoles

A one-pot selective synthesis of 2-substituted C5-, C6-, and C7-nitro- or amino-indoles has been developed from 2-halonitroanilines. These two types of nitrogen-substituted indoles have been selectively obtained by only varying the solvent used in the tandem Sonogashira coupling/heteroannulation reaction. Moreover, from commercially available 2-bromo-4,6-dinitroaniline an unprecedented in situ selective reduction of one of the nitro groups has allowed the synthesis of new 7-amino-5-nitro-2-substituted indoles.