69045-84-7

Basic information

• Product Name: 2,3-Dichloro-5-(trifluoromethyl)pyridine
• Synonyms: 2,3-Dichloro-5-(trifluoromethyl)pyridine ,98%;2,3-Dichloro-5-(trifluoromethyl)pyridine,97%;2,3-Dichloro-5-(trif;3-Dichloro-5-trifluoroMethylpyridine;2,3-Dichloro-5-(trifluoroMethyl)pyridine, 97% 25GR;Pyridine, 2,3-dichloro-5-(trifluoroMethyl)-;2,3-Dichloro-5-(trifluoroMethyl)pyridine(DCTF);DCTF
• CAS NO: 69045-84-7
• Molecular Formula: C₆H₂Cl₂F₃N
• Molecular Weight: 215.99
• EINECS: 410-340-5
• Product Categories: Fluorine series;alkyl chloride;Halides;Pyridines;Pyridine;Pyridine series;Chloropyridines;Halopyridines;C6Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks
• Mol File: 69045-84-7.mol
• Article Data: 22

Chemical Properties

• Melting Point: 8-9 °C
• Boiling Point: 80 °C20 mm Hg(lit.)
• Flash Point: 175 °F
• Appearance: Clear colorless to yellow/Liquid
• Density: 1.549 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00017mmHg at 25°C
• Refractive Index: n20/D 1.475(lit.)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -3.34±0.10(Predicted)
• CAS DataBase Reference: 2,3-Dichloro-5-(trifluoromethyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Dichloro-5-(trifluoromethyl)pyridine(69045-84-7)
• EPA Substance Registry System: 2,3-Dichloro-5-(trifluoromethyl)pyridine(69045-84-7)

Safety Data

• Hazard Codes: Xn,N,Xi
• Statements: 20/22-41-43-51/53-36/37/38
• Safety Statements: 24-26-37/39-61-36
• RIDADR: UN 3082 9/PG 3
• WGK Germany: 2
• TSCA: Yes
• HazardClass: 9
• PackingGroup: III
• Hazardous Substances Data: 69045-84-7(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow liquid

General Description

2,3-Dichloro-5-(trifluoromethyl)pyridine is reported as an intermediate of herbicide. Synthesis of 2,3-dichloro-5-(trifluoromethyl)pyridine has been reported. Palladium-catalyzed monoalkoxycarbonylation of 2,3-dichloro-5-(trifluoromethyl)pyridine has been reported.

InChI:InChI=1/C12H10ClF3N2O/c1-6(2)18-9-4-3-7(10(13)19)5-8(9)17-11(18)12(14,15)16/h3-6H,1-2H3

Synthetic route

2,3-dichloro-5-(trichloromethyl)pyridine (69045-83-6) → 2,3-dichloro-5-trifluoromethylpyridine (69045-84-7)

Conditions	Yield
With hydrogen fluoride; tungsten(VI) chloride at 170 - 180℃; under 1500.15 Torr; for 5h; Reagent/catalyst; Temperature; Pressure; Autoclave;	92%
With antimony(III) fluoride for 0.166667h; Heating; Irradiation;	80.4%
With pyridine; iron(III) chloride; hydrogen fluoride at 130 - 175℃; Autoclave;	73%

2,2-dichloro-3,3,3-trifluoro-propionaldehyde (82107-24-2) + acrylonitrile (107-13-1) → 2,3-dichloro-5-trifluoromethylpyridine (69045-84-7)

Conditions	Yield
copper(l) chloride In acetonitrile at 190℃; for 0.5h;	60%

antimony(III) fluoride (7783-56-4) + 2,3-dichloro-5-(trichloromethyl)pyridine (69045-83-6) → 2,3-dichloro-5-trifluoromethylpyridine (69045-84-7)

Conditions	Yield
With antimonypentachloride

2-chloro-5-trifluoromethylpyridine (52334-81-3) → 2,3-dichloro-5-trifluoromethylpyridine (69045-84-7)

Conditions	Yield
With iron(III) chloride In water
With antimonypentachloride; iron(III) chloride In water
With chlorine; iron(III) chloride
Stage #1: 2-chloro-5-trifluoromethylpyridine under 15001.5 Torr; for 2h; Autoclave; Inert atmosphere; Stage #2: With chlorine at 0 - 150℃; under 15001.5 Torr; for 20h; Temperature; Reagent/catalyst; Inert atmosphere;

2-chloro-5-trifluoromethylpyridine (52334-81-3) + tungsten(VI) chloride (13283-01-7) → 2,3-dichloro-5-trifluoromethylpyridine (69045-84-7)

2-fluoro-3-chloro-5-(trifluoromethyl)pyridine (72537-17-8) → 2,3-dichloro-5-trifluoromethylpyridine (69045-84-7)

Conditions	Yield
With FeCl3

nickel (7440-02-0) + 2-fluoro-3-chloro-5-(trifluoromethyl)pyridine (72537-17-8) → 2,3-dichloro-5-trifluoromethylpyridine (69045-84-7)

Conditions	Yield
With FeCl3 In (2S)-N-methyl-1-phenylpropan-2-amine hydrate

4-formyl-2,4-dichloro-5,5,5-trifluorovaleronitrile → 2,3-dichloro-5-trifluoromethylpyridine (69045-84-7)

3-trichloromethyl-pyridine (3099-50-1) → 2,3-dichloro-5-trifluoromethylpyridine (69045-84-7)

Conditions	Yield
Multi-step reaction with 2 steps 1: phosphorus pentachloride / 16 h / 210 °C / Autoclave 2: hydrogen fluoride; iron(III) chloride; pyridine / 130 - 175 °C / Autoclave View Scheme
Multi-step reaction with 3 steps 1: phosphorus pentachloride / 16 h / 210 °C / Autoclave 2: phosphorus pentachloride / 16 h / 210 °C / Autoclave 3: hydrogen fluoride; iron(III) chloride; pyridine / 130 - 175 °C / Autoclave View Scheme

5-chloro-3-trichloromethyl pyridine → 2,3-dichloro-5-trifluoromethylpyridine (69045-84-7)

Conditions	Yield
Multi-step reaction with 2 steps 1: phosphorus pentachloride / 16 h / 210 °C / Autoclave 2: hydrogen fluoride; iron(III) chloride; pyridine / 130 - 175 °C / Autoclave View Scheme

nicotinic acid (59-67-6) → 2,3-dichloro-5-trifluoromethylpyridine (69045-84-7)

Conditions	Yield
Multi-step reaction with 2 steps 1: phosphorus pentachloride / 14 h / 210 °C / 1500.15 - 27752.8 Torr / Autoclave 2: hydrogen fluoride; iron(III) chloride; pyridine / 130 - 175 °C / Autoclave View Scheme
Multi-step reaction with 2 steps 1: phosphorus pentachloride / 64 h / 185 °C / 18751.9 - 30003 Torr / Autoclave 2: hydrogen fluoride; iron(III) chloride; pyridine / 130 - 175 °C / Autoclave View Scheme
Multi-step reaction with 2 steps 1: phosphorus pentachloride / 72 h / 185 °C / 18751.9 - 30003 Torr / Autoclave 2: hydrogen fluoride; iron(III) chloride; pyridine / 130 - 175 °C / Autoclave View Scheme

3-Methylpyridine (108-99-6) → 2,3-dichloro-5-trifluoromethylpyridine (69045-84-7)

Conditions	Yield
Multi-step reaction with 3 steps 1: tetrachloromethane; chlorine / 0 h / 350 - 400 °C 2: chlorine / 6 h / 150 - 160 °C 3: hydrogen fluoride / 11 h / 170 °C View Scheme

2-chloro-5-(Trichloromethyl)-pyridine (69045-78-9) → 2,3-dichloro-5-trifluoromethylpyridine (69045-84-7)

Conditions	Yield
Multi-step reaction with 2 steps 1: chlorine / 6 h / 150 - 160 °C 2: hydrogen fluoride / 11 h / 170 °C View Scheme

2-chloro-5-trifluoromethylpyridine (52334-81-3) → 2,6-dichloro-3-(trifluoromethyl)pyridine (55304-75-1) + 2,3-dichloro-5-trifluoromethylpyridine (69045-84-7)

Conditions	Yield
Stage #1: 2-chloro-5-trifluoromethylpyridine under 15001.5 Torr; for 2h; Autoclave; Inert atmosphere; Stage #2: With chlorine at 0 - 150℃; under 15001.5 Torr; for 20h; Reagent/catalyst; Inert atmosphere;

2-chloro-5-trifluoromethylpyridine (52334-81-3) → 2,3,6-trichloro-5-trifluoromethylpyridine (80289-91-4) + 2,6-dichloro-3-(trifluoromethyl)pyridine (55304-75-1) + 2,3-dichloro-5-trifluoromethylpyridine (69045-84-7)

Conditions	Yield
Stage #1: 2-chloro-5-trifluoromethylpyridine under 15001.5 Torr; for 2h; Autoclave; Inert atmosphere; Stage #2: With chlorine at 0 - 200℃; under 15001.5 Torr; for 20h; Inert atmosphere;

2,3-dichloro-5-trifluoromethylpyridine (69045-84-7) → 2-fluoro-3-chloro-5-(trifluoromethyl)pyridine (72537-17-8)

Conditions	Yield
With potassium carbonate; cesium fluoride In dimethyl sulfoxide at 120℃; under 18.7519 - 22.5023 Torr; for 4h; Product distribution / selectivity;	100%
With potassium carbonate; cesium fluoride In 1-methyl-pyrrolidin-2-one at 70℃; for 1 - 3h; Product distribution / selectivity;	98%
With potassium fluoride; N-benzyl-N,N,N-triethylammonium chloride In N,N-dimethyl acetamide at 170℃; for 5h; Temperature;	97%

2,6-dimethyl-4-nitro phenol (2423-71-4) + 2,3-dichloro-5-trifluoromethylpyridine (69045-84-7) → 3-chloro-2-(2,6-dimethyl-4-nitrophenoxy)-5-trifluoromethylpyridine (875774-91-7)

Conditions	Yield
With potassium carbonate In ISOPROPYLAMIDE; water; ethyl acetate	100%
With potassium carbonate In ISOPROPYLAMIDE at 155 - 165℃; for 1h;	100%

salicylaldehyde (90-02-8) + 2,3-dichloro-5-trifluoromethylpyridine (69045-84-7) → 2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)benzaldehyde (1379461-07-0)

Conditions	Yield
Stage #1: salicylaldehyde With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.5h; Stage #2: 2,3-dichloro-5-trifluoromethylpyridine In N,N-dimethyl-formamide; mineral oil at 0 - 50℃; for 2h;	100%

2,3-dichloro-5-trifluoromethylpyridine (69045-84-7) + tert-butyl methyl(piperidin-4-yl)carbamate (108612-54-0) → N-methyl tert-butyl [1-{3-chloro-5-(trifluoromethyl)pyridin-2-yl}piperidin-4-yl]carbamate

Conditions	Yield
With potassium carbonate at 100 - 120℃;	100%
With potassium tert-butylate; palladium diacetate; DavePhos In toluene at 120℃; for 12h; Buchwald-Hartwig Coupling; Inert atmosphere;	63%

3-(tert-butoxycarbonylamino)pyrrolidine (99724-19-3) + 2,3-dichloro-5-trifluoromethylpyridine (69045-84-7) → tert-butyl [1-{3-chloro-5-(trifluoromethyl)pyridin-2-yl}pyrrolidin-3-yl]carbamate

Conditions	Yield
With potassium carbonate at 100 - 120℃;	100%

5-tert-butoxycarbonylamino-1-aminopentane (51644-96-3) + 2,3-dichloro-5-trifluoromethylpyridine (69045-84-7) → tert-butyl [5-N-{3-chloro-5-(trifluoromethyl)pyridin-2-yl}aminopentan-1-yl]carbamate

Conditions	Yield
With potassium carbonate at 100 - 120℃;	100%

(endo)-(8-aza-bicyclo[3.2.1]oct-3-yl)-carbamic acid tert-butyl ester (287114-25-4) + 2,3-dichloro-5-trifluoromethylpyridine (69045-84-7) → tert-butyl [8-{3-chloro-5-(trifluoromethyl)pyridin-2-yl}azabicyclo[3.2.1]octan-3-yl]carbamate

Conditions	Yield
With potassium carbonate at 100 - 120℃;	100%

2,3-dichloro-5-trifluoromethylpyridine (69045-84-7) + acetonitrile (75-05-8) → 2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile (157764-10-8)

Conditions	Yield
With sodium methylate at 130℃; under 21002.1 Torr; for 16h; Pressure; Temperature; Reagent/catalyst; Inert atmosphere;	99.2%

copper (12775-96-1, 15158-11-9, 15721-63-8, 16941-75-6, 17493-86-6, 19498-52-3, 20499-83-6, 20499-84-7, 20499-85-8, 20499-86-9, 20573-10-8, 20573-11-9, 21595-51-7, 21595-52-8, 22206-52-6, 26445-28-3, 28959-95-7, 37362-93-9, 39417-05-5, 54603-16-6, 54603-23-5, 54603-32-6, 54603-40-6, 54603-48-4, 54603-81-5, 54603-89-3, 56316-56-4, 95985-91-4, 122297-32-9, 7440-50-8) + 2,3-dichloro-5-trifluoromethylpyridine (69045-84-7) + thiophenol (108-98-5) → 3-chloro-2-phenylthio-5-trifluoromethylpyridine (204641-55-4)

Conditions	Yield
	99%

tert-butyl N-(azepane-4-yl)carbamate + 2,3-dichloro-5-trifluoromethylpyridine (69045-84-7) → tert-butyl [1-{3-chloro-5-(trifluoromethyl)pyridin-2-yl}azepan-4-yl]carbamate

Conditions	Yield
With potassium carbonate at 100 - 120℃;	99%

2,3-dichloro-5-trifluoromethylpyridine (69045-84-7) + t-butyl piperidin-3-ylcarbamate (184637-48-7) → tert-butyl [1-{3-chloro-5-(trifluoromethyl)pyridin-2-yl}-piperidin-3-yl]carbamate

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 100℃;	99%

nitromethane (75-52-5) + 2,3-dichloro-5-trifluoromethylpyridine (69045-84-7) → 3-chloro-2-nitromethyl-5-(trifluoromethyl)pyridine

Conditions	Yield
With tetrabutyl-ammonium chloride; potassium hydroxide at 15℃; Concentration; Temperature; Reagent/catalyst;	98.7%
With potassium tert-butylate In dimethyl sulfoxide at 0 - 27℃; for 14.25h;	95.7%
With potassium hydroxide In dimethyl sulfoxide at 20 - 50℃; for 3.25h;	73.9%
With potassium hydroxide In dimethyl sulfoxide at 20℃;

2,3-dichloro-5-trifluoromethylpyridine (69045-84-7) → 3-chloro-5-(trifluoromethyl)-pyridin-2-yl-hydrazine (89570-82-1)

Conditions	Yield
With hydrazine hydrate In ethanol at 50℃; for 2h;	98.3%
With hydrazine hydrate In ethanol Reflux;	86%
With hydrazine hydrate In ethanol at 40℃; for 24h;	85.8%

5-amino-2-chlorophenol (6358-06-1) + 2,3-dichloro-5-trifluoromethylpyridine (69045-84-7) → 4-chloro 3-(3chloro-5-trifluoromethylpyridin-2-yloxy)aniline

Conditions	Yield
With potassium carbonate; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate In toluene at 60℃; for 1h; Reagent/catalyst; Temperature;	98.2%

2,6-dichloro-4-benzyloxyphenol (155916-12-4) + 2,3-dichloro-5-trifluoromethylpyridine (69045-84-7) → 3,5-dichloro-4-(3-chloro-5-trifluoromethyl-pyridin-2-yloxy)-1-benzyloxybenzene

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide	98%

tert-Butyl acrylate (1663-39-4) + 2,3-dichloro-5-trifluoromethylpyridine (69045-84-7) → tert-butyl 3-(3-chloro-2-oxo-5-(trifluoromethyl)pyridin-1(2H)-yl)propanoate (1448447-86-6)

Conditions	Yield
With 1,10-Phenanthroline; oxygen; silver(I) acetate; palladium diacetate; Trimethylacetic acid In N,N-dimethyl-formamide at 130℃; under 760.051 Torr; for 20h;	98%

2,3-dichloro-5-trifluoromethylpyridine (69045-84-7) + acrylonitrile (107-13-1) → 3-(3-chloro-2-oxo-5-(trifluoromethyl)pyridin-1(2H)-yl)propanenitrile (1053658-44-8)

Conditions	Yield
With 1,10-Phenanthroline; oxygen; silver(I) acetate; palladium diacetate; Trimethylacetic acid In N,N-dimethyl-formamide at 130℃; under 760.051 Torr; for 20h;	98%

1-amino-4-[(tert-butyloxycarbonyl)amino]butane (68076-36-8) + 2,3-dichloro-5-trifluoromethylpyridine (69045-84-7) → tert-butyl [4-N-{3-chloro-5-(trifluoromethyl)pyridin-2-yl}aminobutan-1-yl]carbamate

Conditions	Yield
With potassium carbonate at 100 - 120℃;	98%

N-(p-tolyl)-1H-pyrrole-2-carboxamide (1208109-63-0) + 2,3-dichloro-5-trifluoromethylpyridine (69045-84-7) → 5-(p-tolyl)-3-(trifluoromethyl)pyrido[3,2-e]pyrrolo[1,2-a]pyrazin-6(5H)-one (1344146-20-8)

Conditions	Yield
With caesium carbonate In acetonitrile for 7h; Reflux;	97%

2,3-dichloro-5-trifluoromethylpyridine (69045-84-7) + ethyl 2-cyanoacetate (105-56-6) → ethyl 2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-2-cyanoacetate

Conditions	Yield
With potassium hydroxide In dimethyl sulfoxide at 50℃; for 1h;	97%
Stage #1: 2,3-dichloro-5-trifluoromethylpyridine With potassium carbonate In dimethyl sulfoxide at 20℃; for 0.25h; Stage #2: ethyl 2-cyanoacetate In dimethyl sulfoxide at 80℃; for 2.5h;	90.6%
With potassium hydroxide In 1-methyl-pyrrolidin-2-one at 70 - 80℃; for 2.5h;
Stage #1: ethyl 2-cyanoacetate With tetrabutyl-ammonium chloride; sodium methylate In methanol at 25℃; for 0.5h; Stage #2: 2,3-dichloro-5-trifluoromethylpyridine In methanol at 70℃; for 1h; Reagent/catalyst; Solvent;
Stage #1: 2,3-dichloro-5-trifluoromethylpyridine; ethyl 2-cyanoacetate With potassium carbonate In dimethyl sulfoxide at 70℃; for 12h; Stage #2: With hydrogenchloride In water

2-fluoro-4-methyl-5-(2,2,2-trifluoroethylthio)phenol + 2,3-dichloro-5-trifluoromethylpyridine (69045-84-7) → 3-chloro-2-[2-fluoro-4-methyl-5-(2,2,2-trifluoroethylthio)phenoxy]-5-trifluoromethylpyridine

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 2h;	97%

(R)-piperidin-3-ylcarbamic acid tert-butyl ester (309956-78-3) + 2,3-dichloro-5-trifluoromethylpyridine (69045-84-7) → (R)-tert-butyl (1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperidin-3-yl)carbamate

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 5h;	97%

2,3-dichloro-5-trifluoromethylpyridine (69045-84-7) → 2-(4'-hydroxyphenoxy)-3-chloro-5-trifluoromethylpyridine (69045-89-2)

Conditions	Yield
	96.9%
	96.9%
	93.5%

3-isopropyl-4-[3-(methoxymethoxy)propyl]-1H-pyrazole (628331-02-2) + 2,3-dichloro-5-trifluoromethylpyridine (69045-84-7) → 1-[3-chloro-5-(trifluoromethyl)-2-pyridyl]-3-isopropyl-4-[3-(methoxymethoxy)propyl]-1H-pyrazole (628331-03-3)

Conditions	Yield
With sodium hydride In DMF (N,N-dimethyl-formamide) at 0 - 50℃;	96%

acrylic acid n-butyl ester (141-32-2) + 2,3-dichloro-5-trifluoromethylpyridine (69045-84-7) → butyl 3-(3-chloro-2-oxo-5-(trifluoromethyl)pyridin-1(2H)-yl)propanoate (1448447-79-7)

Conditions	Yield
With 1,10-Phenanthroline; oxygen; silver(I) acetate; palladium diacetate; Trimethylacetic acid In N,N-dimethyl-formamide at 130℃; under 760.051 Torr; for 20h; Catalytic behavior; Reagent/catalyst;	96%

2,3-dichloro-5-trifluoromethylpyridine (69045-84-7) + acrylic acid methyl ester (292638-85-8) → methyl 3-(3-chloro-2-oxo-5-(trifluoromethyl)pyridin-1(2H)-yl)propanoate (1448447-84-4)

Conditions	Yield
With 1,10-Phenanthroline; oxygen; silver(I) acetate; palladium diacetate; Trimethylacetic acid In N,N-dimethyl-formamide at 130℃; under 760.051 Torr; for 20h;	96%

2,3-dichloro-5-trifluoromethylpyridine (69045-84-7) + phenylboronic acid (98-80-6) → 3-chloro-2-phenyl-5-(trifluoromethyl)pyridine (370878-67-4)

Conditions	Yield
With palladium diacetate; potassium carbonate; triphenylphosphine In methanol; acetonitrile at 50℃; for 24h; Suzuki Coupling; Inert atmosphere; regioselective reaction;	96%

ethanol (64-17-5) + carbon monoxide (201230-82-2) + 2,3-dichloro-5-trifluoromethylpyridine (69045-84-7) → diethyl 5-(trifluoromethyl)pyridine-2,3-dicarboxylate (120083-60-5)

Conditions	Yield
With sodium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride at 120℃; under 11251.1 Torr; for 18h;	95%
With 1,1'-bis-(diphenylphosphino)ferrocene; sodium acetate; palladium diacetate at 150℃; under 11400.8 Torr; for 2h; Autoclave;	92%
With 1,1'-bis(diphenylphosphino)ferrocene; palladium diacetate

2,3-dichloro-5-trifluoromethylpyridine (69045-84-7) + (R)-2-(4-hydroxyphenoxy)propionic acid (94050-90-5) → (R)-2-[4-(3-chloro-5-trifluoromethylpyridin-2-yloxy)phenoxy]propanoic acid (95977-29-0)

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide	95%
Stage #1: (R)-2-(4-hydroxyphenoxy)propionic acid With potassium carbonate In N,N-dimethyl-formamide at 70 - 80℃; for 1h; Stage #2: 2,3-dichloro-5-trifluoromethylpyridine at 70 - 80℃; for 8h;	84.4%
Stage #1: (R)-2-(4-hydroxyphenoxy)propionic acid With potassium carbonate In N,N-dimethyl-formamide at 70 - 80℃; for 1h; Stage #2: 2,3-dichloro-5-trifluoromethylpyridine In N,N-dimethyl-formamide at 70 - 80℃; for 8h;	84.4%

Upstream product

• 72537-17-8 2-fluoro-3-chloro-5-(trifluoromethyl)pyridine 
• 7440-02-0 nickel 
• 108-99-6 3-Methylpyridine 
• 69045-78-9 2-chloro-5-(Trichloromethyl)-pyridine 
• 52334-81-3 2-chloro-5-trifluoromethylpyridine 
• 59-67-6 nicotinic acid 
• 3099-50-1 3-trichloromethyl-pyridine 
• 13283-01-7 tungsten(VI) chloride 
• 7783-56-4 antimony(III) fluoride 
• 69045-83-6 2,3-dichloro-5-(trichloromethyl)pyridine 
• 82107-24-2 2,2-dichloro-3,3,3-trifluoro-propionaldehyde 
• 107-13-1 acrylonitrile 

Downstream Products

• 89810-01-5 3-chloro-2-methylamine-5-trifluoromethylpyridine 
• 79623-37-3 3-chloro-5-trifluoromethyl-2-pyridone 
• 72537-17-8 2-fluoro-3-chloro-5-(trifluoromethyl)pyridine 
• 85148-26-1 3-chloro-5-(trifluoromethyl)pyridine 
• 157764-10-8 2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile 
• 888740-13-4 3-(2-{[3-chloro-5-(trifluoromethyl)pyridine-2-yl]oxy}-4-propoxyphenyl)propanoic acid ethyl ester 
• 888740-17-8 ethyl 3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-isopropoxyphenyl)propanoate 
• 888740-23-6 ethyl 3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]propanoate 
• 888740-95-2 2-(2-{1-[2-(benzyloxy)ethyl]-3-isopropoxy-1H-pyrazole-4-yl}ethoxy)-3-chloro-5-(trifluoromethyl)pyridine 
• 150149-16-9 1-(3-chloro-5-trifluoromethylpyridin-2-yl)-5-nitroindazole 
• 163716-82-3 4-[5-(3-chloro-5-trifluoromethyl-pyridin-2-yloxy)-2-nitrophenylthio]-3-oxo-2-(2,4-dichlorophenyl)pentanenitrile 
• 160190-62-5 1-cyano-1-(1-pyrrolidyl)carbonyl-3-[4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)phenoxy]-2-butanone 
• 204641-55-4 3-chloro-2-phenylthio-5-trifluoromethylpyridine 
• 204577-97-9 3-Chloro-2-phenylsulfonyl-5-trifluoromethylpyridine 

Relevant articles and documents

Preparation method of 2, 3-dichloro-5-trifluoromethylpyridine

The invention discloses a preparation method of 2, 3-dichloro-5-trifluoromethylpyridine, and belongs to the technical field of organic synthesis. The comprises the following steps: (1) adding 2, 3-dichloro-5-trichloromethylpyridine into an organic solvent under the condition of 20 to 50 DEG C, so as to obtain an organic solution of 2-chloro-5-trichloromethylpyridine; (2) adding fluorinated quaternary ammonium salt and 1, 2-dicyanotetrafluorobenzene into the organic solution of the 2, 3-dichloro-5-trichloromethylpyridine obtained in the step (1), and uniformly mixing to obtain a reaction system; 3) controlling the temperature of the reaction system to be 30-60 DEG C, and reacting to obtain 2, 3-dichloro-5-trifluoromethylpyridine; and 4) filtering the reaction liquid, and carrying out reduced pressure distillation on the obtained filtrate to obtain the 2, 3-dichloro-5-trifluoromethylpyridine. The method can be completed in one step, cheap fluorinated quaternary ammonium salt is selected as a fluorination reagent, and operation is easy; the raw materials are cheap and easily available, the reaction temperature is low, the reaction time is short, and conditions such as high-temperature, high-pressure and dangerous hydrogen fluoride raw materials are avoided; and the yield of the obtained product is 70-90%, and the gas chromatography detection purity is greater than 99.0%.

Preparation method of 2,3-dichloro-5-trifluoromethylpyridine

The invention provides a preparation method of 2,3-dichloro-5-trifluoromethylpyridine. The method comprises the following steps: carrying out condensation and acidification on 1, 1, 1-trifluoroacetone and nitromethane under the action of alkali to obtain 1-nitro-2-trifluoromethyl propylene; the method comprises the following steps: condensing 1-nitro-2-trifluoromethyl propylene and oxalic acid diester under the action of alkali, and carrying out reduction-cyclization reaction and acidification reaction on the obtained reaction liquid in the presence of a catalyst without separation to obtain a product 2, 3-dihydroxy-5-trifluoromethylpyridine; and then subjecting the 2,3-dihydroxy-5-trifluoromethylpyridine and a chlorination reagent to a chlorination reaction to obtain the 2,3-dichloro-5-trifluoromethylpyridine. The raw materials used in the invention are cheap and easily available, and the reaction selectivity of each step is high. The process does not need special equipment to carry out high-temperature chlorination and high-temperature fluorination reactions and is easy to operate, the target product is high in yield and purity, and the process is suitable for industrial production.

Synthetic method of 2,3-dichloro-5-trifluoromethylpyridine

The invention discloses a synthetic method of 2,3-dichloro-5-trifluoromethylpyridine. The method comprises the following steps that 1,2,3-dichloro-5-trichloromethylpyridine and hydrogen fluoride are subjected to a halogen exchange reaction at the temperature of 140-200 DEG C under the action of a catalyst; 2, the product obtained after the halogen exchange reaction is heated at the pressure of 0.15-1.0 MPa for a pressurizing conversion reaction, and 2,3-dichloro-5-trifluoromethylpyridine is obtained. According to the method, 1, 2,3-dichloro-5-trichloromethylpyridine and hydrogen fluoride are used for the reaction; the method is characterized in that under catalysis of the catalyst, trichloromethylpyridine reacts with hydrogen fluoride, the reaction is carried out at normal pressure at first, then the conversion reaction is carried out under certain pressure and temperature, and therefore the defect that in a traditional process, it is dangerous because a reaction is carried out at high temperature and high pressure is overcome. According to the process, reaction conditions are mild, dangerousness is low, a small quantity of waste gas, waste water and waste solids are produced, and separation is easy.