7251-53-8

Basic information

• Product Name: ethyl 3-hydroxy-1H-pyrazole-4-carboxylate
• Synonyms: ethyl 3-hydroxy-1H-pyrazole-4-carboxylate;1H-Pyrazole-4-carboxylicacid, 2,3-dihydro-3-oxo-, ethyl ester;4-(Ethoxycarbonyl)-3-hydroxy-1H-pyrazole;ethyl 3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate;3-Oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid ethyl ester;Ethyl 5-hydroxy-1H-pyrazole-4-carboxylate;ethyl 3-oxo-1,2-dihydropyrazole-4-carboxylate;3-Hydroxy-1H-Pyrazole-4-Carboxylic Acid Ethyl Ester(WX649081)
• CAS NO: 7251-53-8
• Molecular Formula: C₆H₈N₂O₃
• Molecular Weight: 156.13932
• Mol File: 7251-53-8.mol
• Article Data: 21

Chemical Properties

• Melting Point: 140-142 °C
• Boiling Point: 311.7°C at 760 mmHg
• Flash Point: 142.3°C
• Appearance: /
• Density: 1.272g/cm³
• Vapor Pressure: 0.000302mmHg at 25°C
• Refractive Index: 1.496
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 7.78±0.70(Predicted)
• CAS DataBase Reference: ethyl 3-hydroxy-1H-pyrazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-hydroxy-1H-pyrazole-4-carboxylate(7251-53-8)
• EPA Substance Registry System: ethyl 3-hydroxy-1H-pyrazole-4-carboxylate(7251-53-8)

Safety Data

• Hazardous Substances Data: 7251-53-8(Hazardous Substances Data)

Usage

General Description

Ethyl 3-hydroxy-1H-pyrazole-4-carboxylate is a chemical compound of the pyrazole family with the molecular formula C7H9N2O3. It is characteristically used in a variety of chemical reactions due to its structure and properties. The material is synthetically developed and primarily used in scientific experiments and research. Its essence to the scientific community lies in its potential usability in the creation and development of pharmaceuticals and other chemicals. This chemical is recommended to be handled and used exclusively by individuals with knowledge in chemistry or related fields due to possible health risks and its reactivity under certain conditions.

InChI:InChI=1/C6H8N2O3/c1-2-11-6(10)4-3-7-8-5(4)9/h3H,2H2,1H3,(H2,7,8,9)

Upstream product

• 141-52-6 sodium ethanolate 
• 39513-55-8 1,3-dimethyluracil-5-carbohydrazide 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 1260243-04-6 ethyl 5-amino-1H-pyrazole-4-carboxylate 
• 18856-68-3 diethyl N,N-dimethylaminomethylenemalonate 
• 49597-05-9 propene-1,1,3,3-tetracarboxylic acid tetraethyl ester 
• 6296-99-7 diethyl aminomethylenemalonate 

Downstream Products

• 178424-17-4 1-(tert-butyl) 4-ethyl 3-hydroxy-1H-pyrazole-1,4-dicarboxylate 
• 76205-19-1 1-(para-chlorophenyl)-3-hydroxypyrazole 
• 332070-62-9 ethyl 3-ethoxy-1-ethylpyrazole-4-carboxylate 
• 103626-04-6 ethyl 3-methoxy-1-methyl-1H-pyrazole-4-carboxylate 
• 478968-48-8 ethyl 3-methoxy-1H-pyrazole-4-carboxylate 
• 1173003-60-5 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-carboxylic acid ethyl ester 
• 342024-75-3 ethyl 1-(4-phenoxybenzyl)-3-(4-phenoxybenzyloxy)-1H-pyrazole-4-carboxylate 
• 342023-74-9 ethyl 1-[4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]benzyl]-3-[4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]benzyloxy]-1H-pyrazole-4-carboxylate 
• 342024-08-2 ethyl 1-benzyl-3-benzyloxy-1H-pyrazole-4-carboxylate 
• 178424-16-3 3-[[(4-methoxyphenyl)methyl]oxy]pyrazole-4-carboxylic acid ethyl ester 

Relevant articles and documents

GPR52 MODULATOR COMPOUNDS

The disclosures herein relate to novel compounds of Formula (1): (1) and salts thereof, wherein R1, Q, X, Y and Z are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of disorders associated with GPR52 receptors.

PROCESS OF MAKING CFTR MODULATORS

The disclosure provides processes for synthesizing Compound I, and pharmaceutically acceptable salts thereof.

SOLID FORMS OF MODULATORS OF CFTR

Crystalline and amorphous forms of a potassium salt of Compound (I): are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.