72680-38-7

Basic information

• Product Name: N-(2-Chloro-5-trifluoromethyl-phenyl)-2-(2-oxo-benzothiazol-3-yl)-acetamide
• CAS NO: 72680-38-7
• Molecular Weight: 386.782
• Mol File: 72680-38-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(2-Chloro-5-trifluoromethyl-phenyl)-2-(2-oxo-benzothiazol-3-yl)-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-Chloro-5-trifluoromethyl-phenyl)-2-(2-oxo-benzothiazol-3-yl)-acetamide(72680-38-7)
• EPA Substance Registry System: N-(2-Chloro-5-trifluoromethyl-phenyl)-2-(2-oxo-benzothiazol-3-yl)-acetamide(72680-38-7)

Safety Data

• Hazardous Substances Data: 72680-38-7(Hazardous Substances Data)

Upstream product

• 945-03-9 (2-oxo-1,3-benzothiazol-3(2H)-yl)acetic acid 
• 934-34-9 2(3H)-Benzothiazolone 
• 881-10-7 2-oxo-3-benzothiazolineacetyl chloride 
• 121-50-6 3-amino-4-chlorobenzotrifluoride 

Relevant articles and documents

Synthesis of 2-Oxo-3-benzothiazolineacetyl Chloride (7), 5-Chloro-2-oxo-3-benzothiazolineacetyl Chloride (8) and Derivatives

The reaction of 2-oxo-3-benzothiazolineacetic acid (5) and the 5-chloro analogue 6 with thionyl chloride afforded the titled compounds 7 and 8.The reaction of 7 or 8 with substituted hydrazines, amines or substituted anilines, alcohols and mercaptans furnished the hydrazides 9-14, acetamides and acetanilides 16-21, esters 26-30 and thiolesters 31-37, respectively.Alternate routes for the synthesis of hydrazide 15, acetamides and acetanilides 22-25 and thiolesters 35-36 are described.The reaction of 2-oxo-3(2H)-benzothiazolineacetonitrile with thioacetic acid under acidic conditions afforded 2-oxo-3-benzothiazolineethanethioamide (38).