76-19-7

Basic information

• Product Name: PERFLUOROPROPANE
• Synonyms: genetron218;hfc218;octafluoro-propan;optison;propane,octafluoro-;R 218;r218;Perfluoropropaneminimum
• CAS NO: 76-19-7
• Molecular Formula: C₃F₈
• Molecular Weight: 188.02
• EINECS: 200-941-9
• Product Categories: refrigerants;Organics
• Mol File: 76-19-7.mol

Chemical Properties

• Melting Point: -183 °C
• Boiling Point: -39 °C
• Appearance: colorless, odorless gas
• Density: 1.35
• Vapor Pressure: 6250mmHg at 25°C
• Refractive Index: 1.2210 (estimate)
• Storage Temp.: Refrigerator
• CAS DataBase Reference: PERFLUOROPROPANE(CAS DataBase Reference)
• NIST Chemistry Reference: PERFLUOROPROPANE(76-19-7)
• EPA Substance Registry System: PERFLUOROPROPANE(76-19-7)

Safety Data

• Hazard Codes: F
• Safety Statements: 9-23-38
• RIDADR: 2424
• HazardClass: 2.2
• Hazardous Substances Data: 76-19-7(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 76-19-7 differently. You can refer to the following data:
1. Ultrasound contrast imaging in cardiology and radiology (diagnostic).
2. Perfluoropropane is a non flammable greenhouse gas that is used in management of retinal tears in eye. It is also used in refrigeration mixtures.

Brand name

Definity (Bristol-Myers Squibb).

General Description

PERFLUOROPROPANE is a colorless, odorless gas. PERFLUOROPROPANE is relatively inert. The mixture is nonflammable and nontoxic, though asphyxiation may occur because of displacement of oxygen. Exposure of the container to prolonged heat or fire can cause PERFLUOROPROPANE to rupture violently and rocket.

Reactivity Profile

PERFLUOROPROPANE is chemically inert in many situations, but can react violently with strong reducing agents such as the very active metals and the active metals. They suffer oxidation with strong oxidizing agents and under extremes of temperature.

Purification Methods

Purify it for pyrolysis studies by passage through a copper vessel containing CoF3 at about 270o, then fractionally distil it. [Steunenberg & Cady J Am Chem Soc 74 4165 1952.] Also purify it by several trap-to-trap distillations at low temperatures [Simons & Block J Am Chem Soc 59 1407 1937].

InChI:InChI=1/C3F8/c4-1(5,2(6,7)8)3(9,10)11

Synthetic route

perfluoropropylene (116-15-4) → freon-218 (76-19-7)

Conditions	Yield
With xenon difluoride; silicon tetrafluoride at 90℃; for 13h; Fluorination;	95%
With nickel(II) fluoride; fluorine at 100℃;	62%
With AgFAsF6 In hydrogen fluoride at -196 - -70℃; for 0.0833333h; Yield given;
With cobalt (III) fluoride; Hexafluoroethane at 92℃; for 0.0333333h; Rate constant; Product distribution; var. time, var. temp.;
With fluorine at -20℃; under 1125.11 Torr; for 7.22222E-06h;

1,2-propanediene (463-49-0) → carbon tetrafluoride (75-73-0) + freon-218 (76-19-7)

Conditions	Yield
With fluorine; sodium fluoride at -100 - -10℃; for 12h;	A n/a B 84%

perfluoropropylene (116-15-4) → Hexafluoropropene oxide (428-59-1) + freon-218 (76-19-7) + C3F12OSe + C3F16O2Se2

Conditions	Yield
With xenon bis-pentafluoroseleniumoxide at 65℃; for 84h;	A 36% B n/a C 51% D 11%

propane-1-sulfonamide (24243-71-8) → freon-218 (76-19-7) + Hexafluoroethane (76-16-4) + ethanesulfonyl fluoride (754-03-0) + 1-perfluoropropanesulfonyl fluoride (423-40-5)

Conditions	Yield
With hydrogen fluoride current: 4.5 to 5.5 V; 0.3 to 0.6 Adm-2; Further byproducts given;	A 2.8% B 3.1% C 4.3% D 40%

acetone (67-64-1) → freon-218 (76-19-7) + trifluoroacetyl fluoride (354-34-7) + Hexafluoroacetone (684-16-2)

Conditions	Yield
With copper; sodium fluoride at -100℃;	A n/a B n/a C 39%
With copper; sodium fluoride at -100℃; Mechanism;	A n/a B n/a C 39%
With copper; sodium fluoride at -100℃;

C3F17IO2Te2 (105062-53-1) → freon-218 (76-19-7) + 1,1,1,2,2,3,3-heptafluoro-3-iodo-propane (754-34-7) + C3F12OTe (91600-26-9) + TeF6

Conditions	Yield
at 115℃; for 26h;	A n/a B n/a C 30% D n/a

perfluoropropanesulfonic acid (423-41-6) → fluorosulfonyl fluoride (640723-20-2, 2699-79-8, 12769-73-2) + Carbonyl fluoride (353-50-4) + freon-218 (76-19-7) + perfluoropropanoyl fluoride (422-61-7) + sulfur dioxide (7446-09-5)

Conditions	Yield
in Pt tube at 500°C, 1 h, incomplete reaction;	A n/a B n/a C 19% D 23% E n/a

di-n-propylamine (142-84-7) → freon-218 (76-19-7) + N,N-Difluor-heptafluor-n-propylamin (423-32-5) + 2,2,3,3,3-pentafluoro-N-(perfluoropropyl)propanimidoyl fluoride (356-64-9) + F-(N-F-Fluoro,N,N-di-n-propylamine) (1554-24-1)

Conditions	Yield
With hydrogen fluoride at 7 - 8℃; Fluorination; Cleavage; Electrolysis;	A 20.1% B 1.3% C 1.8% D 7.8%
With hydrogen fluoride at 7 - 8℃; for 10.9167h; Fluorination; Cleavage; Electrolysis;	A n/a B n/a C 1.9% D 6.2%

trifluoromethan (75-46-7) → polytetrafluoroethylene (116-14-3) + carbon tetrafluoride (75-73-0) + freon-218 (76-19-7) + perfluoropropylene (116-15-4) + Hexafluoroethane (76-16-4)

Conditions	Yield
With activated carbon supported potassium at 799.84℃; under 750.075 Torr; Pyrolysis; Inert atmosphere;	A 16.1% B n/a C n/a D 14.4% E n/a

ethylpropylamine (20193-20-8) → freon-218 (76-19-7) + N,N-Difluor-heptafluor-n-propylamin (423-32-5) + 2,2,3,3,3-pentafluoro-N-(1,1,2,2,2-pentafluoro-ethyl)-propionimidoyl fluoride + F-(N-Fluoro,N-ethyl,N-n-propylamine)

Conditions	Yield
With hydrogen fluoride at 7 - 8℃; for 6.55h; Fluorination; Cleavage; Electrolysis;	A n/a B 2.6% C 2.4% D 2.8%

N-isopropylethylamine (19961-27-4) → freon-218 (76-19-7) + N,N-Difluor-heptafluorisopropylamin (662-23-7) + perfluoro(4-methyl-3-aza-2-pentene) (2344-11-8) + C5F13N

Conditions	Yield
With hydrogen fluoride at 7 - 8℃; for 6.46667h; Fluorination; Cleavage; Electrolysis; Further byproducts given;	A n/a B n/a C 3.3 % Chromat. D 2.4%

carbon tetrafluoride (75-73-0) → freon-218 (76-19-7)

Conditions	Yield
bei der Zersetzung im elektrischen Lichtbogen;

carbon tetrafluoride (75-73-0) → freon-218 (76-19-7) + Hexafluoroethane (76-16-4)

Conditions	Yield
im Kohlelichtbogen;
In neat (no solvent) other Radiation; decomposition of CF4 by (60)Co-γ-rays, formation of C2F6 and C3F8;; determination by ESR;;

2,2,3-trichloro-1,1,1,3,3-pentafluoropropane (1599-41-3) + 1,1,2,2-tetrachloro-1,3,3,3-tetrafluoropropane (2268-44-2) → freon-218 (76-19-7) + 2-Chloro-F-propane (76-18-6)

Conditions	Yield
With aluminum(III) fluoride; nitrogen; fluorine at 245 - 355℃;

2,2,3-trichloro-1,1,1,3,3-pentafluoropropane (1599-41-3) → freon-218 (76-19-7)

Conditions	Yield
With aluminum(III) fluoride; fluorine at 250℃;

methane (34557-54-5) → freon-218 (76-19-7)

Conditions	Yield
With copper; fluorine

perfluoropropyl chloride (422-86-6) → freon-218 (76-19-7)

Conditions	Yield
With antimony pentafluoride at 175℃;

1,1,1,2,2,3,3-heptafluoro-3-iodo-propane (754-34-7) → freon-218 (76-19-7)

Conditions	Yield
With gold; fluorine at 150℃;
With boron trifluoride
With chlorine trifluoride at 100℃;
With antimony pentafluoride at 320℃;
With cobalt (III) fluoride at 400℃;

pentafluoropropionitrile (422-04-8) → freon-218 (76-19-7)

Conditions	Yield
With fluorine at 275℃;

butyric acid (107-92-6) → freon-218 (76-19-7)

Conditions	Yield
With hydrogen fluoride at -3℃; Electrolysis;

benzene (71-43-2) → freon-218 (76-19-7)

Conditions	Yield
With copper; fluorine at 90℃;

trichloro-acetic acid-(3-hydroxy-propyl ester) (7297-44-1) → freon-218 (76-19-7) + trichlorofluoromethane (75-69-4) + trifluoroacetyl fluoride (354-34-7) + fluorodichloroacetyl fluoride (354-18-7)

Conditions	Yield
With fluorine; sodium fluoride Further byproducts given;

trichloro-acetic acid-(3-hydroxy-propyl ester) (7297-44-1) → freon-218 (76-19-7) + trichlorofluoromethane (75-69-4) + trifluoroacetyl fluoride (354-34-7) + trichloroacetyl fluoride (354-13-2)

Conditions	Yield
With fluorine; sodium fluoride Further byproducts given;

trichloro-acetic acid-(3-hydroxy-propyl ester) (7297-44-1) → freon-218 (76-19-7) + trichlorofluoromethane (75-69-4) + trifluoroacetyl fluoride (354-34-7) + difluoromalonyl difluoride (5930-67-6)

Conditions	Yield
With fluorine; sodium fluoride Further byproducts given;

trichloro-acetic acid-(3-hydroxy-propyl ester) (7297-44-1) → freon-218 (76-19-7) + trichlorofluoromethane (75-69-4) + trifluoroacetyl fluoride (354-34-7) + pentafluoroethyl oxyfluoride (3848-94-0)

Conditions	Yield
With fluorine; sodium fluoride Further byproducts given;

trichloro-acetic acid-(3-hydroxy-propyl ester) (7297-44-1) → freon-218 (76-19-7) + trichlorofluoromethane (75-69-4) + trifluoroacetyl fluoride (354-34-7) + 1-fluoroxy 2-chlorotetrafluoroethane (2203-54-5)

Conditions	Yield
With fluorine; sodium fluoride Further byproducts given;

trichloro-acetic acid-(3-hydroxy-propyl ester) (7297-44-1) → freon-218 (76-19-7) + trichlorofluoromethane (75-69-4) + trifluoroacetyl fluoride (354-34-7) + 1-fluoroxy 2,2-dichlorotrifluoroethane (1454-98-4)

Conditions	Yield
With fluorine; sodium fluoride Further byproducts given;

trichloro-acetic acid-(3-hydroxy-propyl ester) (7297-44-1) → freon-218 (76-19-7) + trichlorofluoromethane (75-69-4) + trifluoroacetyl fluoride (354-34-7) + 1,1,1-Trichlor-2-fluoroxy-perfluoraethan (1454-97-3)

Conditions	Yield
With fluorine; sodium fluoride Further byproducts given;

trichloro-acetic acid-(3-hydroxy-propyl ester) (7297-44-1) → freon-218 (76-19-7) + trichlorofluoromethane (75-69-4) + trifluoroacetyl fluoride (354-34-7) + 3-chlorotetrafluoropropionyl fluoride (5930-66-5)

Conditions	Yield
With fluorine; sodium fluoride Further byproducts given;

trichloro-acetic acid-(3-hydroxy-propyl ester) (7297-44-1) → freon-218 (76-19-7) + trichlorofluoromethane (75-69-4) + trifluoroacetyl fluoride (354-34-7) + C3F8O2 (5930-62-1)

Conditions	Yield
With fluorine; sodium fluoride Further byproducts given;

freon-218 (76-19-7) + benzoyl fluoride (455-32-3) → perfluoroisopropyl phenyl ketone (56112-35-7)

Conditions	Yield
With cesium fluoride In N,N-dimethyl-formamide for 3h;	95.1%

freon-218 (76-19-7) + 2H,2H-nonafluoro-1-iodo-3-methylbutane (756-84-3) → 2-Iodo-6-trifluoromethyl-5,5-dihydroperfluoroheptane (118161-95-8) + 7H,7H-perfluoro-2-iodo-4,8-dimethylnonane

Conditions	Yield
at 200℃; for 48h;	A 71% B 7%

freon-218 (76-19-7) → trifluoromethan (75-46-7)

Conditions	Yield
With hydrogen at 800℃; Pyrolysis;

freon-218 (76-19-7) → Bromotrifluoromethane (75-63-8)

Conditions	Yield
With bromine at 850℃;