81474-46-6

Basic information

• Product Name: 4-BROMO-7-METHOXY-BENZO[1,3]DIOXOLE-5-CARBOXYLIC ACID METHYL ESTER
• Synonyms: 4-Bromo-7-methoxy-1,3-benzodioxole-5-carboxylicacidmethylester;METHYL 4-BROMO-7-METHOXY-BENZO[1,3]DIOXOLE-5-CARBOXYLATE;METHYL 2-BROMO-3,4-METHYLENEDIOXY-5-METHOXYBENZOATE;2-BROMO-3,4-DIOXYMETHYLENE-5-METHYLOXYMETHYL BENZOATE;4-BROMO-7-METHOXY-BENZO[1,3]DIOXOLE-5-CARBOXYLIC ACID METHYL ESTER;Methyl 4-bromo-7-methoxy-benzo[1,3]dioxole-5-;1,3-Benzodioxole-5-carboxylic acid, 4-broMo-7-Methoxy-, Methyl ester;Methyl 4-broMo-7-Methoxybenzo[d][1,3]dioxole-5-carboxylate
• CAS NO: 81474-46-6
• Molecular Formula: C₁₀H₉BrO₅
• Molecular Weight: 289.08
• Mol File: 81474-46-6.mol
• Article Data: 12

Chemical Properties

• Melting Point: 106.5℃
• Boiling Point: 356.325 °C at 760 mmHg
• Flash Point: 169.299 °C
• Appearance: White crystalline powder
• Density: 1.618 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.569
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-BROMO-7-METHOXY-BENZO[1,3]DIOXOLE-5-CARBOXYLIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-7-METHOXY-BENZO[1,3]DIOXOLE-5-CARBOXYLIC ACID METHYL ESTER(81474-46-6)
• EPA Substance Registry System: 4-BROMO-7-METHOXY-BENZO[1,3]DIOXOLE-5-CARBOXYLIC ACID METHYL ESTER(81474-46-6)

Safety Data

• Hazardous Substances Data: 81474-46-6(Hazardous Substances Data)

Usage

General Description

4-Bromo-7-methoxy-benzo[1,3]dioxole-5-carboxylic acid methyl ester is a chemical compound with the molecular formula C11H9BrO5. It is a methyl ester derivative of 4-bromo-7-methoxy-benzo[1,3]dioxole-5-carboxylic acid, which belongs to the class of benzoic acid esters. 4-Bromo-7-methoxy-benzo[1,3]dioxole-5-carboxylic acid methyl ester is used in pharmaceutical research and development, particularly in the synthesis of potential drug candidates. Its specific properties and potential applications may vary depending on the context of its use, but it is commonly studied for its potential medicinal and pharmacological properties. Additionally, it may also be used as a reference compound in analytical chemistry or as an intermediate in organic synthesis.

InChI:InChI=1/C10H9BrO5/c1-13-6-3-5(10(12)14-2)7(11)9-8(6)15-4-16-9/h3H,4H2,1-2H3

Upstream product

• 75-11-6 diiodomethane 
• 123685-25-6 5-methoxy-3,4-dihydroxy-2-bromobenzoic acid methyl ester 
• 22934-58-3 methyl 7-methoxybenzo[d][1,3]dioxole-5-carboxylate 
• 408340-58-9 7-hydroxy-2-oxo-benzo[1,3]dioxole-5-carboxylic acid 
• 143883-73-2 2-bromo-5-O-methyl gallic acid 
• 3934-84-7 3,4-dihydroxy-5-methoxybenzoic acid 
• 149-91-7 3,4,5-trihydroxybenzoic acid 
• 526221-05-6 2-ethoxy-7-hydroxy-benzo[1,3]dioxole-5-carboxylic acid methyl ester 
• 3934-86-9 methyl 3,4-dihydroxy-5-methoxybenzoate 
• 99-24-1 methyl galloate 
• 74-95-3 1,1-dibromomethane 

Downstream Products

• 111897-19-9 DDB 
• 90749-17-0 4,4'-dimethoxy-5,6,5',6'-dimethylenedioxy-2,2'-dibenzyl alcohol 
• 111897-21-3 dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylenedioxybiphenyl-2,2'-dicarboxylic acid 
• 143883-74-3 6-phenyl-3,9-dimethoxy-1,2-methylenedioxy-10,11-methylenedioxy-6,7-dihydro-5H-dibenz[c,e]azepine 
• 143883-75-4 6-(m-chlorophenyl)-3,9-dimethoxy-1,2-methylenedioxy-10,11-methylenedioxy-6,7-dihydro-5H-dibenz(c,e)azepin 
• 1084695-63-5 C₁₇H₁₄O₆ 
• 66096-75-1 (4-bromo-7-methoxybenzo[1,3]dioxol-5-yl)methanol 
• 22934-59-4 (7-methoxybenzo[d][1,3]dioxol-5-yl)methanol 
• 128-62-1 (±)-α-noscapine 

Relevant articles and documents

Gamma-bifendate intermediate, synthesis method thereof, and synthesis method of gamma-bifendate

The invention discloses a gamma-bifendate intermediate, a synthesis method thereof, and a synthesis method of gamma-bifendate. The gamma-bifendate intermediate is 4-methoxy-5, 6-methylenedioxy-2-methoxycarbonyl phenylboronic acid, and based on the gamma-bifendate intermediate, the invention further provides a novel synthesis method of gamma-bifendate. Ullmann reaction is not adopted, and Suzuki-Miyaura reaction is introduced as a key step of asymmetric synthesis, so that synthesis is simple, isomeride does not occur, the preparation process is optimized and upgraded, reaction steps are reduced, and reaction conditions are optimized.

Synthesis method of 2-bromo-3, 4-methylenedioxy-5-methoxybenzoic acid methyl ester

The invention belongs to the field of chemical pharmacy, and specifically discloses a preparation method of 2-bromo-3, 4-methylenedioxy-5-methoxybenzoic acid methyl ester. The preparation method comprises the following steps: by taking gallic acid as a ra

Total synthesis of graphislactones A, C, D, and H, of ulocladol, and of the originally proposed and revised structures of graphislactones e and F

Graphislactones A-H and the structurally related ulocladol are highly oxygenated resorcylic lactones produced by lichens and fungi. We present total syntheses of graphislactones A, C-F, H and of ulocladol. Graphislactones E, F, and H were synthesized for the first time. The spectra of graphislactones E and F synthesized as the originally proposed structures were not in agreement with published data. Consequently, revised structures for these compounds are proposed, whose correctness is unambiguously proven by total synthesis and comparison of the spectroscopic data. Key steps in all syntheses are Suzuki couplings for the construction of the central biaryl bond and Dakin reactions to supply further hydroxy groups required in these highly oxygenated substrates. Graphislactones A, C, and H, acylated graphislac- tone D and ulocladol were prepared in 8-11 steps with 7-20% yield starting with purchasable compounds, where the longest linear sequence consists of 5-9 steps. The syntheses are thus significantly shorter than the previously published syntheses of graphislactones A-D and of ulocladol. Graphis- lactones E and F were synthesized in 8 steps, where the longest linear sequences consist of 6 and 5 steps, respectively. They were isolated as the respective acetylated compounds with 25 and 10% yield.