863666-27-7

Basic information

• Product Name: (R)-5-(2-aminopropyl)-2-methoxybenzenesulfonamide D-tartrate
• Synonyms: (R)-5-(2-aminopropyl)-2-methoxybenzenesulfonamide D-tartrate
• CAS NO: 863666-27-7
• Molecular Weight: 394.403
• Mol File: 863666-27-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-5-(2-aminopropyl)-2-methoxybenzenesulfonamide D-tartrate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-5-(2-aminopropyl)-2-methoxybenzenesulfonamide D-tartrate(863666-27-7)
• EPA Substance Registry System: (R)-5-(2-aminopropyl)-2-methoxybenzenesulfonamide D-tartrate(863666-27-7)

Safety Data

• Hazardous Substances Data: 863666-27-7(Hazardous Substances Data)

Upstream product

• 147-71-7 D-tartaric acid 
• 112244-38-9 (+/-)-5-(2-aminopropyl)-2-methoxybenzenesulfonamide 
• 112101-81-2 5-((R)-2-amino-1-propyl)-2-methoxybenzenesulphonamide 

Downstream Products

• 112101-81-2 5-((R)-2-amino-1-propyl)-2-methoxybenzenesulphonamide 

Relevant articles and documents

Improved process for the preparation of tamsulosin hydrochloride

Ellman's sulfinamide reagent is used in asymmetric synthesis of Tamsulosin hydrochloride. The enantiomeric ratio achieved is 87:13. The crystallization of the same with dibenzoyl tartarate afforded the product 2 with 99.5% ee.

A PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY PURE (R) OR (S)-5-(2-AMINOPROPYL)-2-METHOXYBENZENESULFONAMIDE

The invention relates to a process for the manufacture of optically pure (R) or (S)-5-(2-aminopropyl)-2-methoxybenzenesulfonamide with D-i.e. (2S, 3S) or L-i.e. (2R, 3R)-tartaric acid to form a mixture of diastereomeric salts, separating the diastereomeric salts by fractional crystallization in a mixture of solvent systems and at the specified temperature range and contacting the individual salts so separated with a base to provide said R-(-)-5-(2-aminopropyl)-2-methoxybenzenesulfonamide or S-(+)-5-(2-amino propyl)-2-methoxybenzenesulfonamide.