875446-29-0

Basic information

• Product Name: 4-fluoro-5-isopropyl-2-methoxyphenylboronic acid
• Synonyms: 4-fluoro-5-isopropyl-2-methoxyphenylboronic acid;(4-Fluoro-5-isopropyl-2-Methoxyphenyl)boronic ac;Boronic acid, B-[4-fluoro-2-Methoxy-5-(1-Methylethyl)phenyl]-;Boronic acid, [4-fluoro-2-Methoxy-5-(1-Methylethyl)phenyl]-;[4-fluoro-2-methoxy-5-(propan-2-yl)phenyl]boronic acid;EOS-61124;Anacetrapib Intermediate 6
• CAS NO: 875446-29-0
• Molecular Formula: C₁₀H₁₄BFO₃
• Molecular Weight: 212
• EINECS: 1592732-453-0
• Mol File: 875446-29-0.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 324.0±52.0 °C(Predicted)
• Appearance: /
• Density: 1.15±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 8.69±0.58(Predicted)
• CAS DataBase Reference: 4-fluoro-5-isopropyl-2-methoxyphenylboronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-fluoro-5-isopropyl-2-methoxyphenylboronic acid(875446-29-0)
• EPA Substance Registry System: 4-fluoro-5-isopropyl-2-methoxyphenylboronic acid(875446-29-0)

Safety Data

• Hazardous Substances Data: 875446-29-0(Hazardous Substances Data)

Usage

Uses

(4-Fluoro-5-isopropyl-2-methoxyphenyl)boronic acid

Upstream product

• 1383814-83-2 4-fluoro-2-methoxy-5-(2-propenyl)phenylboronic acid 
• 1383814-82-1 1-bromo-4-fluoro-2-methoxy-5-(1-methylvinyl)benzene 
• 958029-46-4 2-(5-bromo-2-fluoro-4-methoxyphenyl)propan-2-ol 
• 914221-54-8 1-(5-bromo-2-fluoro-4-methoxyphenyl)ethan-1-one 
• 450-88-4 1-bromo-4-fluoro-2-methoxybenzene 
• 348-57-2 2,4-difluorobromobenzene 
• 944317-92-4 1-bromo-4-fluoro-2-methoxy-5-(propan-2-yl)-benzene 
• 5419-55-6 Triisopropyl borate 
• 96826-25-4 2-(2-fluoro-4-methoxyphenyl)-2-isopropanol 
• 74457-86-6 1-(2-fluoro-4-methoxyphenyl)-1-ethanone 
• 875446-55-2 2-fluoro-4-methoxy-1-(prop-1-en-2-yl)benzene 
• 875446-57-4 1-fluoro-4-iodo-2-isopropenyl-5-methoxybenzene 

Downstream Products

• 875446-37-0 anacetrapib 
• 875548-97-3 (4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methanol 
• 875549-49-8 (+)-(5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4'-fluoro-2'-methoxy-5'-(propan-2-yl)-4-(trifluoromethyl)biphenyl-2-yl]methyl}-4,4-dimethyl-1,3-oxazolidin-2-one 
• 1312671-81-0 (-)-(5S)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4'-fluoro-2'-methoxy-5'-(propan-2-yl)-4-(trifluoromethyl)biphenyl-2-yl]methyl}-4,4-dimethyl-1,3-oxazolidin-2-one 
• 1312671-76-3 (+)-(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4'-fluoro-2'-methoxy-5'-(propan-2-yl)-4-(trifluoromethyl)biphenyl-2-yl]methyl}-4,5-dimethyl-1,3-oxazolidin-2-one 
• 875548-98-4 2'-(bromomethyl)-4-fluoro-2-methoxy-5-(propan-2-yl)-4'-(trifluoromethyl)biphenyl 
• 1312671-75-2 5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4'-fluoro-2'-methoxy-5'-(propan-2-yl)-4-(trifluoromethyl)biphenyl-2-yl]methyl}-4,4-dimethyl-1,3-oxazolidin-2-one 
• 1374135-29-1 [5-[4-fluoro-2-methoxy-5-(propan-2-yl)phenyl]-2-(methylsulfanyl)pyrimidin-4-yl]methanol 
• 875551-28-3 2'-(chloromethyl)-4-fluoro-5-isopropyl-2-methoxy-4'-(trifluoromethyl)biphenyl 
• 1353643-42-1 C₃₀H₂₅F₁₀NO₅S 

Relevant articles and documents

Preparation method of anacetrapib intermediate

The invention relates to a preparation method of an anacetrapib intermediate, namely (4-fluoro-5-isopropyl-2-methoxyphenyl) boric acid. According to the preparation method, 4-fluoro-1-bromo-2-methoxyl-5-isopropyl benzene and triisopropyl borate carry out reactions under the action of a catalyst to prepare (4-fluoro-5-isopropyl-2-methoxyphenyl) boric acid. A novel catalyst is adopted, the novel catalyst can be diisopropyl magnesium lithium chloride (i-Pr2Mg LiCl), 2,2',6,6'-tetramethyl piperidine magnesium chloride lithium chloride (TMP MgCl LiCl), or 2,4,6-trimethylphenyl magnesium bromide lithium chloride (Mes MgBr LiCl). The reaction conditions are mild; the reaction speed is quick; the product is single; the purification is convenient; the purity and yield of obtained intermediate are high, and the preparation method is suitable for industrial production.

Process for a CETP Inhibitor

An efficient process is disclosed for producing the compound of formula I, which is the CETP inhibitor anacetrapib, which raises HDL-cholesterol and reduces LDL-cholesterol in human patients and may be effective for treating or reducing the risk of developing atherosclerosis:

PROCESS FOR A CETP INHIBITOR

An efficient process is disclosed for producing the compound of formula I, which is the CETP inhibitor anacetrapib, which raises HDL-cholesterol and reduces LDL-cholesterol in human patients and may be effective for treating or reducing the risk of developing atherosclerosis:.