875548-98-4

Basic information

• Product Name: 2'-(BroMoMethyl)-4-fluoro-5-isopropyl-2-Methoxy-4'-(trifluoroMethyl)biphenyl
• Synonyms: 2'-(BroMoMethyl)-4-fluoro-5-isopropyl-2-Methoxy-4'-(trifluoroMethyl)biphenyl;Anacetrapib Intermediate 4
• CAS NO: 875548-98-4
• Molecular Formula: C₁₈H₁₇BrF₄O
• Molecular Weight: 405.2245928
• Product Categories: Anacetrapib;MK 0859
• Mol File: 875548-98-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2'-(BroMoMethyl)-4-fluoro-5-isopropyl-2-Methoxy-4'-(trifluoroMethyl)biphenyl(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-(BroMoMethyl)-4-fluoro-5-isopropyl-2-Methoxy-4'-(trifluoroMethyl)biphenyl(875548-98-4)
• EPA Substance Registry System: 2'-(BroMoMethyl)-4-fluoro-5-isopropyl-2-Methoxy-4'-(trifluoroMethyl)biphenyl(875548-98-4)

Safety Data

• Hazardous Substances Data: 875548-98-4(Hazardous Substances Data)

Usage

General Description

2'-(BromoMethyl)-4-fluoro-5-isopropyl-2-Methoxy-4'-(trifluoroMethyl)biphenyl is a chemical compound with a complex structure that includes bromine, fluorine, methyl, methoxy, and isopropyl groups. 2'-(BroMoMethyl)-4-fluoro-5-isopropyl-2-Methoxy-4'-(trifluoroMethyl)biphenyl belongs to the class of biphenyl derivatives, which are aromatic hydrocarbons containing two phenyl rings. It is commonly used in organic synthesis and medicinal chemistry as a building block for the preparation of various biologically active compounds. The presence of bromine, fluorine, and trifluoromethyl groups in this compound makes it an important intermediate for the development of pharmaceuticals, agrochemicals, and materials. Its unique structure and properties make it a valuable resource for research and development in the field of organic chemistry.

Upstream product

• 1383676-74-1 4-fluoro-5-isopropyl-2-methoxy-2'-(methoxymethyl)-4'-(trifluoromethyl)biphenyl 
• 64372-62-9 (2-chloro-5-(trifluoromethyl)phenyl)methanol 
• 163444-17-5 2-iodo-4-(trifluoromethyl)aniline 
• 96826-25-4 2-(2-fluoro-4-methoxyphenyl)-2-isopropanol 
• 74457-86-6 1-(2-fluoro-4-methoxyphenyl)-1-ethanone 
• 6526-08-5 2-amino-5-(trifluoromethyl)benzonitrile 
• 702641-05-2 [2-iodo-5-(trifluoromethyl)phenyl]methanol 
• 702641-04-1 2-iodo-5-(trifluoromethyl)benzoic acid 
• 1262414-96-9 2-(2-fluoro-4-methoxyphenyl)isopropane 
• 875446-57-4 1-fluoro-4-iodo-2-isopropenyl-5-methoxybenzene 
• 875446-55-2 2-fluoro-4-methoxy-1-(prop-1-en-2-yl)benzene 
• 868166-20-5 2-iodo-5-(trifluoromethyl)benzonitrile 
• 875446-29-0 [4-fluoro-2-methoxy-5-(propan-2-yl)phenyl]boronic acid 
• 875548-97-3 (4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methanol 

Downstream Products

• 1312671-76-3 (+)-(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4'-fluoro-2'-methoxy-5'-(propan-2-yl)-4-(trifluoromethyl)biphenyl-2-yl]methyl}-4,5-dimethyl-1,3-oxazolidin-2-one 
• 875549-49-8 (+)-(5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4'-fluoro-2'-methoxy-5'-(propan-2-yl)-4-(trifluoromethyl)biphenyl-2-yl]methyl}-4,4-dimethyl-1,3-oxazolidin-2-one 
• 1312671-81-0 (-)-(5S)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4'-fluoro-2'-methoxy-5'-(propan-2-yl)-4-(trifluoromethyl)biphenyl-2-yl]methyl}-4,4-dimethyl-1,3-oxazolidin-2-one 
• 1312671-75-2 5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4'-fluoro-2'-methoxy-5'-(propan-2-yl)-4-(trifluoromethyl)biphenyl-2-yl]methyl}-4,4-dimethyl-1,3-oxazolidin-2-one 
• 1370452-28-0 5-(3,5-bis(trifluoromethyl)phenyl)-3-((4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl)methyl)-4-methylthiazolidin-2-one 

Relevant articles and documents

Synthesis of intermediates for preparing anacetrapib and derivates thereof

The present invention relates to the field of organic chemistry, more specifically to the synthesis of intermediate compounds which can be used in the synthesis of pharmaceutically active agents such as anacetrapib or derivatives thereof.

COMPOUNDS FOR INCREASE OF HDL-C LEVEL AND USES THEREOF

Compounds for inhibiting cholesterol ester transport protein (CETP) activity and application thereof. These compounds include compounds of formula (I), and the pharmaceutically acceptable salts, solvates, non-covalent complexes,chelates, or prodrugs there

CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS

Compounds of Formula (I), including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compounds of Formula