875446-55-2

Basic information

• Product Name: Benzene, 2-fluoro-4-methoxy-1-(1-methylethenyl)-
• CAS NO: 875446-55-2
• Molecular Formula: C10H11FO
• Molecular Weight: 166.195
• Mol File: 875446-55-2.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Benzene, 2-fluoro-4-methoxy-1-(1-methylethenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 2-fluoro-4-methoxy-1-(1-methylethenyl)-(875446-55-2)
• EPA Substance Registry System: Benzene, 2-fluoro-4-methoxy-1-(1-methylethenyl)-(875446-55-2)

Safety Data

• Hazardous Substances Data: 875446-55-2(Hazardous Substances Data)

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 96826-25-4 2-(2-fluoro-4-methoxyphenyl)-2-isopropanol 
• 74457-86-6 1-(2-fluoro-4-methoxyphenyl)-1-ethanone 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 676-58-4 methylmagnesium chloride 

Downstream Products

• 875446-29-0 [4-fluoro-2-methoxy-5-(propan-2-yl)phenyl]boronic acid 
• 875548-97-3 (4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methanol 
• 875549-49-8 (+)-(5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4'-fluoro-2'-methoxy-5'-(propan-2-yl)-4-(trifluoromethyl)biphenyl-2-yl]methyl}-4,4-dimethyl-1,3-oxazolidin-2-one 
• 1312671-81-0 (-)-(5S)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4'-fluoro-2'-methoxy-5'-(propan-2-yl)-4-(trifluoromethyl)biphenyl-2-yl]methyl}-4,4-dimethyl-1,3-oxazolidin-2-one 
• 1312671-76-3 (+)-(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4'-fluoro-2'-methoxy-5'-(propan-2-yl)-4-(trifluoromethyl)biphenyl-2-yl]methyl}-4,5-dimethyl-1,3-oxazolidin-2-one 
• 875548-98-4 2'-(bromomethyl)-4-fluoro-2-methoxy-5-(propan-2-yl)-4'-(trifluoromethyl)biphenyl 
• 1312671-75-2 5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4'-fluoro-2'-methoxy-5'-(propan-2-yl)-4-(trifluoromethyl)biphenyl-2-yl]methyl}-4,4-dimethyl-1,3-oxazolidin-2-one 
• 944317-92-4 1-bromo-4-fluoro-2-methoxy-5-(propan-2-yl)-benzene 
• 875446-37-0 anacetrapib 
• 875551-28-3 2'-(chloromethyl)-4-fluoro-5-isopropyl-2-methoxy-4'-(trifluoromethyl)biphenyl 
• 875446-57-4 1-fluoro-4-iodo-2-isopropenyl-5-methoxybenzene 
• 1262414-96-9 2-(2-fluoro-4-methoxyphenyl)isopropane 

Relevant articles and documents

Ni-Catalyzed Reductive Allylation of α-Chloroboronates to Access Homoallylic Boronates

The transition-metal-catalyzed allylation reaction is an efficient strategy for the construction of new carbon-carbon bonds alongside allyl or homoallylic functionalization. Herein we describe a Ni-catalyzed reductive allylation of α-chloroboronates to efficiently render the corresponding homoallylic boronates, which could be readily converted into valuable homoallylic alcohols or amines or 1,4-diboronates. This reaction features a broad substrate scope with good functional group compatibility that is complementary to the existing methods for the preparation of homoallylic boronates.

Novel synthetic method for (4-fluoro-5-isopropyl-methoxyphenyl)boric acid

The invention discloses a novel synthetic method for (4-fluoro-5-isopropyl-methoxyphenyl)boric acid. According to the method, easily available and cheap 2-fluoro-4-methoxyacetophenone is used as a raw material and subjected to a Witting reaction, a hydrog

Biphenyl-substituted oxazolidinones as cholesteryl ester transfer protein inhibitors: Modifications of the oxazolidinone ring leading to the discovery of anacetrapib

The development of the structure-activity studies leading to the discovery of anacetrapib is described. These studies focused on varying the substitution of the oxazolidinone ring of the 5-aryloxazolidinone system. Specifically, it was found that substitution of the 4-position with a methyl group with the cis-stereochemistry relative to the 5-aryl group afforded compounds with increased cholesteryl ester transfer protein (CETP) inhibition potency and a robust in vivo effect on increasing HDL-C levels in transgenic mice expressing cynomolgus monkey CETP.