912469-49-9Relevant articles and documents
Total synthesis of bysspectin A
Yang, Feilong,Liu, Xiaoyu,Shi, Xiang,Wang, Yong,Hu, Guoru,Lin, Sheng,Jiao, Xiaozhen,Xie, Ping
, p. 3101 - 3107 (2019)
Bysspectin A (1), an unusual polyketide-derived octaketide dimer, has highly selective inhibitory activities against human carboxylesterase 2 (hCE2) with an IC50 value of 2.01 μM. Herein, we report the first synthesis of this natural product. The synthesis relies upon a key Cu-catalysed domino Sonogashira-cyclization process.
Gold superacid-catalyzed preparation of benzo[c]thiophenes
Debrouwer, Wouter,Seigneur, Ruben A. J.,Heugebaert, Thomas S. A.,Stevens, Christian V.
supporting information, p. 729 - 732 (2015/01/09)
A three-step synthesis of benzo[c]thiophenes is presented in which the key transformation is the gold-catalyzed 5-exo-dig migratory cycloisomerization of a diallyl thioacetal. It was shown that a small amount of in situ generated HAuCl4 from AuCl3 is the active catalytic species. A mechanism was proposed.
Convergence in [2+2+2] synthesis of β-phenylnaphthalene motif in polyaromatic natural products
Takemura, Isao,Imura, Koreaki,Matsumoto, Takashi,Suzuki, Keisuke
, p. 6673 - 6676 (2007/10/03)
Two optional routes to β-phenylnaphthalene structure are developed by introducing α- and β-styryl groups onto different positions in the benzocyclobutene ring followed by ring enlargement.
