912551-99-6

Basic information

• Product Name: 1-fluoro-2-propylbenzene
• Synonyms: 1-fluoro-2-propylbenzene
• CAS NO: 912551-99-6
• Molecular Weight: 138.185
• Mol File: 912551-99-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-fluoro-2-propylbenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-fluoro-2-propylbenzene(912551-99-6)
• EPA Substance Registry System: 1-fluoro-2-propylbenzene(912551-99-6)

Safety Data

• Hazardous Substances Data: 912551-99-6(Hazardous Substances Data)

Upstream product

• 348-51-6 1-chloro-2-fluorobenzene 
• 446-52-6 2-Fluorobenzaldehyde 
• 166949-93-5 1-[3-(methylsulfonyloxy)propyl]-2-fluorobenzene 
• 76727-24-7 3-(2-fluorophenyl)propan-1-ol 
• 18944-77-9 2-fluorocinnamic acid 
• 1643-26-1 3-(2-fluorophenyl)propionic acid 
• 201486-97-7 2-fluoro-1-(3-iodopropyl)benzene 

Downstream Products

• 912552-11-5 cis-(1S,2R)-1,2-dihydroxy-4-fluoro-3-propylcyclohexa-3,5-diene 

Relevant articles and documents

Generation and Cyclization of a Benzyne-Tethered Alkyllithium: Preparation of 4-Substituted Indans

-

Site-Selective C(sp3)–H Functionalization of Fluorinated Alkanes Driven by Polar Effects Using a Tungstate Photocatalyst

The TBADT-catalyzed C(sp3)–H functionalization of perfluorophenyl- and perfluoroalkyl-substituted alkanes was studied to determine how the fluorous substituents affect site-selectivity. Alkylation of alkyl-substituted perfluorobenzene avoids α-C–H bonds, unlike their alkylbenzene counterparts, allowing site-selective functionalization of C–H bonds remote to the aromatic ring. Alkylation of alkanes having a perfluoroalkyl group also avoided α-C–H bonds. Radical polar effects in the SH2 transition states could explain this avoidance of α-C–H functionalization.