93742-43-9

Basic information

• Product Name: 2-(5-PHENYL-2H-TETRAZOL-2-YL)ETHANOL
• Synonyms: CHEMBRDG-BB 5380951;2-(5-PHENYL-2H-TETRAZOL-2-YL)ETHANOL;2-(5-PHENYL-2H-TETRAAZOL-2-YL)ETHANOL;TIMTEC-BB SBB014721;2-(5-phenyl-2H-tetrazol-2-yl)ethanol(SALTDATA: FREE)
• CAS NO: 93742-43-9
• Molecular Formula: C₉H₁₀N₄O
• Molecular Weight: 190.2019
• Mol File: 93742-43-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 399.8°C at 760 mmHg
• Flash Point: 195.6°C
• Appearance: /
• Density: 1.33g/cm³
• Vapor Pressure: 4.14E-07mmHg at 25°C
• Refractive Index: 1.663
• CAS DataBase Reference: 2-(5-PHENYL-2H-TETRAZOL-2-YL)ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(5-PHENYL-2H-TETRAZOL-2-YL)ETHANOL(93742-43-9)
• EPA Substance Registry System: 2-(5-PHENYL-2H-TETRAZOL-2-YL)ETHANOL(93742-43-9)

Safety Data

• Hazardous Substances Data: 93742-43-9(Hazardous Substances Data)

Usage

General Description

2-(5-phenyl-2H-tetrazol-2-yl)ethanol is a chemical compound with the molecular formula C10H11N3O. It is a tetrazole derivative with a 2-phenylethanol group attached to the tetrazole ring. 2-(5-PHENYL-2H-TETRAZOL-2-YL)ETHANOL is used in pharmaceutical research and drug development due to its potential biological activities, such as anti-inflammatory and analgesic effects. It can also act as a ligand for metal ions, making it useful in coordination chemistry studies. Additionally, it may have applications in the development of new materials and organic synthesis strategies. However, further research is needed to fully understand and harness the potential of 2-(5-phenyl-2H-tetrazol-2-yl)ethanol in various fields.

InChI:InChI=1/C9H10N4O/c14-7-6-13-11-9(10-12-13)8-4-2-1-3-5-8/h1-5,14H,6-7H2

Upstream product

• 93764-48-8 1-(2-ethoxycarbonyl-2-iodo-1-phenylethyl)-5-phenyltetrazole 
• 93742-50-8 1-(2-ethoxycarbonyl-2-hydroxy-1-phenylethyl)-5-phenyltetrazole 
• 18039-42-4 5-phenyl-2H-1,2,3,4-tetrazole 
• 540-51-2 2-bromoethanol 
• 50-00-0 formaldehyd 
• 20743-49-1 2-methyl-5-phenyl-2H-tetrazole 
• 75-21-8 oxirane 
• 18039-42-4 5-Phenyl-1H-tetrazole 

Downstream Products

• 131727-62-3 1-chloro-2-(5-phenyltetrazol-2-yl)ethane 
• 134792-24-8 1-phenylsulphonyloxy-2-(5-phenyltetrazol-2-yl)ethane 
• 2458-26-6 3-phenylpyrazole 
• 107933-56-2 5-phenyl-2-vinyl-2H-tetrazole 

Relevant articles and documents

Selective and Potent Monoamine Oxidase Type B Inhibitors: 2-Subtituted 5-Aryltetrazole Derivatives

Twenty new 2-(cyanoalkyl)tetrazoles (15 and 16) and twenty new 2-(hydroxyalkyl)tetrazoles (17 and 18) were synthesized and investigated in vitro for their abilities to inhibit selectivity rat brain monoamine oxidase (MAO) B over MAO A.Most of then were MAO B inhibitors and those bearing a sunstituted 4-(arylmethoxy)phenyl group in the position 5 of the tetrazole ring had IC50 values between 8 νM for 18d and 2 nM for 16a (30 nM for lazabemide) with a selectivity toward MAO B of 37000 for 16a.The reversibility of their inhibitory activity was demonstrated by in vitro dialysis tests.The 5--2-(2-cyanoethyl)-tetrazole (16a) its derivative 16h and the 5--2-(2-hydroxyethyl)-tetrazole (18a) and its derivative 18h were found to be potent, in vitro selective, and competitive MAO B inhibitors.Tetrazole 16a can be considered one of the most active and selective competitive MAO B inhibitors known up to now.This compound was selected for ex vivo experiments and shown to be a strong and reversible MAO B inhibitor with a short duration of action after oral administration at 5 mg/kg.The structure-activity approach gives rise to the great inportance of lipophilicity over electronic effects of the compounds in these series.

Synthesis of Imidazoles from Alkenes

Alkenes are converted into imidazoles through their epoxides by a sequence involving ring-opening with readily available 2-tributylstannyltetrazoles (8), dehydration of the resulting alcohols (9) using methyltriphenoxyphosphonium iodide in a improved procedure to give 1-alkenyltetrazoles (12), which give imidazoles (17) on photolysis.