937716-80-8

Basic information

• Product Name: 2-phenyl-7-bromobenzo[b]furan
• Synonyms: 2-phenyl-7-bromobenzo[b]furan
• CAS NO: 937716-80-8
• Molecular Weight: 273.129
• Mol File: 937716-80-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-phenyl-7-bromobenzo[b]furan(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-7-bromobenzo[b]furan(937716-80-8)
• EPA Substance Registry System: 2-phenyl-7-bromobenzo[b]furan(937716-80-8)

Safety Data

• Hazardous Substances Data: 937716-80-8(Hazardous Substances Data)

Upstream product

• 937716-67-1 (E)-1-phenylethanone O-(2-bromophenyl)oxime 
• 603-78-1 2,3-dibromobenzoic acid 
• 100-52-7 benzaldehyde 
• 1829-34-1 2-hydroxy-3-bromobenzaldehyde 
• 28165-46-0 3-bromo-2-hydroxybenzyl alcohol 
• 98-88-4 benzoyl chloride 
• 608-33-3 2,6-dibromophenol 
• 536-74-3 phenylacetylene 

Relevant articles and documents

Strategy for Overcoming Full Reversibility of Intermolecular Radical Addition to Aldehydes: Tandem C-H and C-O Bonds Cleaving Cyclization of (Phenoxymethyl)arenes with Carbonyls to Benzofurans

An intermolecular addition of carbon radicals enabled by a cascade radical coupling strategy is developed. It includes an intermolecular alkyl radical addition to a carbonyl group followed by an intramolecular alkoxy radical addition to haloarenes and produces substituted benzofurans in high yields. The radical nature of this reaction is explored by radical trapping experiments and EPR analysis. The mechanism is investigated by KIE experiments and control experiments. This method could provide rapid and practical access to the key intermediate of TAM-16, a safe and potent antibacterial agent for treating tuberculosis, and, therefore, is of great importance for organic synthesis and the pharmaceutical industry.

One-pot synthesis of 2-substituted benzo[b]furans via Pd-tetraphosphine catalyzed coupling of 2-halophenols with alkynes

A catalyst composed of [Pd(η3-C3H 5)Cl]2 and N,N,N',N'-tetra(diphenylphosphinomethyl) pyridine-2,6-diamine (L) was found to be effective for one-pot synthesis of 2-substituted benzo[b]furans from 2-halophenols and alkynes. For 2-bromo-3-hydroxypyridine, the catalyst loading could be as low as 1 ppm and the turnover number (TON) was up to 870000. the Partner Organisations 2014.