940943-42-0

Basic information

• Product Name: N-(5-acetyl-pyridin-2-yl)-4-iodo-benzenesulfonamide
• Synonyms: N-(5-acetyl-pyridin-2-yl)-4-iodo-benzenesulfonamide
• CAS NO: 940943-42-0
• Molecular Weight: 402.212
• Mol File: 940943-42-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(5-acetyl-pyridin-2-yl)-4-iodo-benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(5-acetyl-pyridin-2-yl)-4-iodo-benzenesulfonamide(940943-42-0)
• EPA Substance Registry System: N-(5-acetyl-pyridin-2-yl)-4-iodo-benzenesulfonamide(940943-42-0)

Safety Data

• Hazardous Substances Data: 940943-42-0(Hazardous Substances Data)

Upstream product

• 98-61-3 p-Iodobenzenesulfonyl chloride 
• 19828-20-7 1-(6-aminopyridin-3-yl) methyl ketone 

Downstream Products

• 941695-52-9 N-(5-acetyl-pyridin-2-yl)-4-(3-pyrrolidin-1-yl-propoxy)-benzenesulfonamide 
• 1092521-64-6 C₂₁H₂₁N₃O₄S 
• 1092521-67-9 C₂₁H₂₇N₃O₄S 
• 1092521-65-7 C₁₇H₂₀N₂O₅S 
• 940943-40-8 N-(5-Acetyl-pyridin-2-yl)-4-(3-dimethylamino-propoxy)-benzenesulfonamide 
• 1092521-66-8 C₁₉H₂₅N₃O₄S 
• 941695-48-3 N-(5-acetyl-pyridin-2-yl)-4-(3-hydroxy-propoxy)-benzenesulfonamide 
• 940943-43-1 N-(5-Acetyl-pyridin-2-yl)-4-(2-dimethylamino-ethoxy)-benzenesulfonamide 

Relevant articles and documents

Identification of KD5170: A novel mercaptoketone-based histone deacetylase inhibitor

We report the identification of KD5170, a potent mercaptoketone-based Class I and II-histone deacetylase inhibitor that demonstrates broad spectrum cytotoxic activity against a range of human tumor-derived cell lines. KD5170 exhibits robust and sustained histone H3 hyperacetylation in HCT-116 xenograft tumors following single oral or iv dose and inhibition of tumor growth following chronic dosing.

INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE

Disclosed herein are carbonyl compounds of having the structural formula: or a salt, ester, or prodrug thereof, Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, c