astemizole basic information |
product name: | astemizole |
synonyms: | 1-((4-fluorophenyl)methyl)-n-(1-(2-(4-methoxyphenyl)ethyl)-4-piperidinyl)-1h-b;1-(p-fluorobenzyl)-2-((1-(2-(p-methoxyphenyl)ethyl)piperid-4-yl)amino)benzim;1-(p-fluorobenzyl)-2-((1-(p-methoxyphenethyl)-4-piperidyl)amino)benzimidazole;1h-benzimidazol-2-amine,1-((4-fluorophenyl)methyl)-n-(1-(2-(4-methoxyphenyl)et;astemison;astemizol;astemizol(inn-spanish);astemizolum(inn-latin) |
cas: | 68844-77-9 |
mf: | c28h31fn4o |
mw: | 458.57 |
einecs: | 272-441-9 |
product categories: | aromatics;heterocycles;intermediates & fine chemicals;pharmaceuticals;histamine receptor;amines;ascabiol |
mol file: | 68844-77-9.mol |
astemizole chemical properties |
melting point | 172.9°c |
storage temp. | store at +4°c |
safety information |
hazard codes | xn |
risk statements | 22-36/37/38 |
safety statements | 26-36 |
wgk germany | 3 |
rtecs | dd8968000 |
hazardous substances data | 68844-77-9(hazardous substances data) |
astemizole usage and synthesis |
chemical properties | crystalline solid |
usage | nonsedating-type histamine h1-receptor antagonist. potential for combination therapy with antivancer drugs such as doxorubicin in resistant leukemia. antihistaminic |
usage | scabicide |
biological activity | orally active, potent histamine h 1 antagonist (ic 50 = 4 nm) that displays 20-fold, > 250-fold and > 250-fold selectivity over 5-ht, dopamine and muscarinic acetylcholine receptors respectively. exhibits antimalarial activity in multidrug resistant strains in vitro (ic 50 = 227 - 734 nm). also potent herg k + channel blocker (ic 50 = 0.9 nm) that displays cardiotoxicity in vivo . |
astemizole preparation products and raw materials |
raw materials | iodomethane-->bromoethane-->1,4-dimethoxybenzene |
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