TIANFU CHEM Isoniazid CAS NO.54-85-3

isoniazid basic information
product name: isoniazid
synonyms: 4-pyridinecarbohydrazide;4-pyridinecarboxylic acid hydrazide;akos bbs-00004103;hycozid;labotest-bb lt00146690;inah;isonicotinic acid hydrazide;isoniazide
cas: 54-85-3
mf: c6h7n3o
mw: 137.14
einecs: 200-214-6
product categories: amide;amines;aromatics;intermediates & fine chemicals;pharmaceuticals;nydrazid;antituberculotic;api
mol file: 54-85-3.mol
isoniazid structure
isoniazid chemical properties
melting point 171-173 °c(lit.)
fp >250°c
storage temp. refrigerator
solubility 125g/l
form crystals or crystalline powder
color white or colorless
ph 6-8 (50g/l, h2o, 20℃)
water solubility 14 g/100 ml (25 ºc)
sensitive air sensitive
merck 14,5186
brn 119374
stability: stability stable, but may be air or light sensitive. combustible. incompatible with strong oxidizing agents, chloral, aldehydes, iodine, ferric salts, hypochlorites.
cas database reference 54-85-3(cas database reference)
nist chemistry reference isoniazid(54-85-3)
epa substance registry system 4-pyridinecarboxylic acid, hydrazide(54-85-3)
safety information
hazard codes xn
risk statements 22-38-40-36/37/38
safety statements 37-36/37/39-26
ridadr 2811
wgk germany 3
rtecs ns1751850
tsca yes
packinggroup iii
hs code 29333999
hazardous substances data 54-85-3(hazardous substances data)

isoniazid usage and synthesis
chemical properties white crystalline powder
uses antibacterial, tuberculostatic
uses antibiotic for treatment of mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. metabolized by hepatic n-acetyltransferase (nat) and cytochrome p450 2e1 (cyp2e1) to form hepatotoxins. sele ctively induces expression of cyp2e1. reversibly inhibits cyp2c19 and cyp3a4 activities, and mechanistically inactivates cyp1a2, cyp2a6, cyp2c19 and cyp3a4 at clinically relevant concentrations. antib acterial (tuberculostatic).
uses for the treatment of all forms of tuberculosis in which organisms are susceptible.
definition chebi: a carbohydrazide obtained by formal condensation between pyridine-4-carboxylic acid and hydrazine.
general description odorless colorless or white crystals or white crystalline powder. taste is slightly sweet at first and then bitter. ph (1% aqueous solution) 5.5-6.5. ph (5% aqueous solution) 6-8.
air & water reactions sensitive to air and light. absorbs insignificant amounts of moisture at 77°f at relative humidities up to approximately 90%. water soluble. dust can be explosive when suspended in air at specific concentrations.
reactivity profile isoniazid is incompatible with chloral, aldehydes, iodine, hypochlorites and ferric salts. isoniazid is also incompatible with oxidizers. isoniazid may react with sugars and ketones. isoniazid can react as a weak acid or a weak base. isoniazid can be decomposed by oxidative and reductive reactions.
fire hazard isoniazid is combustible.