ArticleEnhanced Cellular Polysulfides Negatively Regulate TLR4 Signaling and Mitigate Lethal Endotoxin Shock
-
Add time:09/04/2019 Source:sciencedirect.com
SummaryCysteine persulfide and cysteine polysulfides are cysteine derivatives having sulfane sulfur atoms bound to cysteine thiol. Accumulating evidence has suggested that cysteine persulfides/polysulfides are abundant in prokaryotes and eukaryotes and play important roles in diverse biological processes such as antioxidant host defense and redox-dependent signal transduction. Here, we show that enhancement of cellular polysulfides by using polysulfide donors developed in this study resulted in marked inhibition of lipopolysaccharide (LPS)-initiated macrophage activation. Polysulfide donor treatment strongly suppressed LPS-induced pro-inflammatory responses in macrophages by inhibiting Toll-like receptor 4 (TLR4) signaling. Other TLR signaling stimulants—including zymosan A-TLR2 and poly(I:C)-TLR3—were also significantly suppressed by polysulfur donor treatment. Administration of polysulfide donors protected mice from lethal endotoxin shock. These data indicate that cellular polysulfides negatively regulate TLR4-mediated pro-inflammatory signaling and hence constitute a potential target for inflammatory disorders.
We also recommend Trading Suppliers and Manufacturers of Sodium polysulfide (cas 1344-08-7). Pls Click Website Link as below: cas 1344-08-7 suppliers
Prev:Chapter Fifteen - Polysulfide Flow Batteries
Next:Kinetics and mechanism of polysulfides formation by a reaction between hydrogen sulfide and orthorhombic cyclooctasulfur) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- ReviewRecent progress on confinement of polysulfides through physical and chemical methods09/08/2019
- A selective and sensitive method for quantification of endogenous polysulfide production in biological samples09/07/2019
- ArticleSodium-Sulfur Batteries with a Polymer-Coated NASICON-type Sodium-Ion Solid Electrolyte09/06/2019
- Kinetics and mechanism of polysulfides formation by a reaction between hydrogen sulfide and orthorhombic cyclooctasulfur09/05/2019
- Chapter Fifteen - Polysulfide Flow Batteries09/03/2019
- In-situ tracking of NaFePO4 formation in aqueous electrolytes and its electrochemical performances in Na-ion/polysulfide batteries09/02/2019
- Electrocatalysis driven high energy density Li-ion polysulfide battery09/01/2019
- High-energy density room temperature sodium-sulfur battery enabled by Sodium polysulfide (cas 1344-08-7) catholyte and carbon cloth current collector decorated with MnO2 nanoarrays08/31/2019
- Development of low-cost sodium-aqueous polysulfide hybrid batteries08/30/2019
-
Health and Chemical more >
-
Related Products
- Sodium 2,4-dimethylbenzenesulfonate
- SODIUM γ-FLUORO-β-HYDROXYBUTYRATE
- Sodium ((3-methoxy-1-methyl-3-oxo-1-propenyl)amino)phenylacetate
- Sodium (+)-10-camphorsulfonate
- Sodium (2-carbamoylphenoxy)acetate
- Sodium (2-methyl-4-chlorophenoxy)acetate
- Sodium (6R,7R)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate pentahydrate
- Sodium (C10-16)alkylbenzenesulfonate
- Sodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)amino)propyl)-1,3-benzodioxole-2,2-
- Sodium (S)-lactate