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Name |
Trapidil |
EINECS | 239-434-2 |
CAS No. | 15421-84-8 | Density | 1.21 g/cm3 |
PSA | 46.32000 | LogP | 1.27890 |
Solubility | N/A | Melting Point |
98-99.4° (Pfeifer); 102-104° from heptane (Tenor) |
Formula | C10H15N5 | Boiling Point | N/A |
Molecular Weight | 205.263 | Flash Point | N/A |
Transport Information | N/A | Appearance | N/A |
Safety | 26 | Risk Codes | 36/37/38 |
Molecular Structure | Hazard Symbols | Xi | |
Synonyms |
s-Triazolo[1,5-a]pyrimidine,7-(diethylamino)-5-methyl- (6CI,8CI);4-(Diethylamino)-6-methyl-1,3,3a,7-tetraazaindene;5-Methyl-7-(diethylamino)-1,2,4-triazolo[1,5-a]pyrimidine;5-Methyl-7-(diethylamino)-s-triazolo[1,5-a]pyrimidine;AR 12008;Avantrin;Rocornal;Trapymin;Trapymine;[1,2,4]Triazolo[1,5-a]pyrimidin-7-amine,N,N-diethyl-5-methyl-; |
Article Data | 5 |
1. Introduction of Trapidil
Trapidil, with the IUPAC Name of N,N-Diethyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine, is one kind of white or almost white crystalline powder. Trapidil has been used for anti-angina drug.
2. Properties of Trapidil
(1)Density: 1.2 g/cm3; (2)Index of Refraction: 1.625; (3)XLogP3-AA: 1.7; (4)H-Bond Donor: 0; (5)H-Bond Acceptor: 4.
3. Structure Descriptors of Trapidil
You could convert the following datas into the molecular structure:
(1).Canonical SMILES: CCN(CC)C1=CC(=NC2=NC=NN12)C
(2).InChI: InChI=1S/C10H15N5/c1-4-14(5-2)9-6-8(3)13-10-11-7-12-15(9)10/h6-7H,4-5H2,1-3H3
(3).InChIKey: GSNOZLZNQMLSKJ-UHFFFAOYSA-N
4. Toxicity of Trapidil
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 155mg/kg (155mg/kg) | Pharmazie. Vol. 26, Pg. 554, 1971. | |
mouse | LD50 | intravenous | 101mg/kg (101mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 232, 1979. | |
mouse | LD50 | oral | 380mg/kg (380mg/kg) | Pharmazie. Vol. 26, Pg. 554, 1971. | |
mouse | LD50 | subcutaneous | 132mg/kg (132mg/kg) | Pharmazie. Vol. 26, Pg. 554, 1971. | |
rat | LD50 | intraperitoneal | 100mg/kg (100mg/kg) | Pharmazie. Vol. 26, Pg. 554, 1971. | |
rat | LD50 | intravenous | 76mg/kg (76mg/kg) | Pharmazie. Vol. 26, Pg. 554, 1971. | |
rat | LD50 | oral | 235mg/kg (235mg/kg) | Pharmazie. Vol. 26, Pg. 554, 1971. | |
rat | LD50 | subcutaneous | 100mg/kg (100mg/kg) | Pharmazie. Vol. 26, Pg. 554, 1971. |