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(-)-1-[(4-Chlorophenyl)phenylmethyl]piperazine
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Name

(-)-1-[(4-Chlorophenyl)phenylmethyl]piperazine

 EINECS N/A
CAS No. 300543-56-0 Density 1.158
PSA 15.27000 LogP 3.60130
Solubility Soluble in chloroform, methanol, and dichloromethane. Slightly soluble in water. Melting Point 91-93oC
Formula C17H19 Cl N2 Boiling Point 409.1oC at 760 mmHg
Molecular Weight 286.804 Flash Point 193.3oC
Transport Information N/A Appearance N/A
Safety Risk Codes N/A
Molecular Structure Molecular Structure of 300543-56-0 ((-)-1-[(4-Chlorophenyl)phenylmethyl]piperazine) Hazard Symbols N/A
Synonyms

(-)-1-[(4-Chlorophenyl)phenylmethyl]piperazine;(R)-1-(p-Chlorobenzhydryl)piperazine

Article Data 10

(-)-1-[(4-Chlorophenyl)phenylmethyl]piperazine Synthetic route

1161573-31-4

(R)-(-)-1-[(4-chlorophenyl)phenylmethyl]piperazine N-acetyl-L-phenylalanine salt

300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

Conditions
ConditionsYield
With sodium hydroxide; water at 20℃; for 12.5h; Product distribution / selectivity;99%
With sodium hydroxide; water In ethyl acetate Product distribution / selectivity;90%
943987-59-5

(-)-1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methoxyphenyl)sulfonyl]piperazine

300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

Conditions
ConditionsYield
Stage #1: (-)-1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methoxyphenyl)sulfonyl]piperazine With hydrogen bromide; acetic acid at 70 - 75℃; for 3h; Industry scale;
Stage #2: With sodium hydroxide In water at 0 - 35℃; pH=~ 12 - ~ 14; Product distribution / selectivity; Industry scale;		92.7%
942283-97-8

(-)-1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methylphenyl)sulfonyl]piperazine

300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

Conditions
ConditionsYield
Stage #1: (-)-1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methylphenyl)sulfonyl]piperazine With hydrogen bromide; acetic acid; 4-hydroxy-benzoic acid at 25℃; for 17h;
Stage #2: With sodium hydroxide In water Product distribution / selectivity;		84.8%
821-48-7

bis-(2-chloroethyl)amine hydrochloride

163837-57-8

(R)-(4-chlorophenyl)(phenyl)methylamine

300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

Conditions
ConditionsYield
Stage #1: bis-(2-chloroethyl)amine hydrochloride; (R)-(4-chlorophenyl)(phenyl)methylamine With N-ethyl-N,N-diisopropylamine for 3h; Heating / reflux;
Stage #2: With diethylamine at 60℃; for 5h; Heating / reflux;
Stage #3: With sodium hydroxide; water pH=10 - 11;
Stage #1: bis-(2-chloroethyl)amine hydrochloride; (R)-(4-chlorophenyl)(phenyl)methylamine With N-ethyl-N,N-diisopropylamine for 3h; Reflux;
Stage #2: With diethylamine at 60℃; Reflux;
941576-99-4

(R)-(+)-4-(4-chlorophenyl)-phenylmethyl-piperazine-1-carboxylic acid-2,2,2-trichloroethylester

300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

Conditions
ConditionsYield
With sodium hydroxide; water In isopropyl alcohol at 20 - 100℃; Product distribution / selectivity;
1136010-90-6

C24H23ClN2O2

300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

Conditions
ConditionsYield
With sodium hydroxide; water In isopropyl alcohol for 3 - 3.5h; Product distribution / selectivity; Heating / reflux;n/a
1155402-57-5

C25H25ClN2O2

300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

Conditions
ConditionsYield
With sodium hydroxide; water In isopropyl alcohol for 1.5h; Product distribution / selectivity; Heating / reflux;
1155402-66-6

C25H25ClN2O3

300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

Conditions
ConditionsYield
With sodium hydroxide; water In isopropyl alcohol for 2.75h; Product distribution / selectivity; Heating / reflux;
1155402-68-8

C24H22ClN3O4

300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

Conditions
ConditionsYield
With sodium hydroxide; water In isopropyl alcohol at 50℃; for 3.5h; Product distribution / selectivity;
1136010-92-8

C25H25ClN2O2

300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

Conditions
ConditionsYield
With sodium hydroxide; water In isopropyl alcohol at 100℃; for 5h; Product distribution / selectivity;

(-)-1-[(4-Chlorophenyl)phenylmethyl]piperazine Chemical Properties

Systematic Name: 1-[(4-Chlorophenyl)(phenyl)methyl]piperazine
Synonyms of (-)-1-[(4-Chlorophenyl)phenylmethyl]piperazine (CAS NO.300543-56-0): (R)-1-(p-Chlorobenzhydryl)piperazine
CAS NO: 300543-56-0
Molecular Formula: C17H19ClN2
Molecular Weight: 286.80
Molecular Structure:
H bond acceptors: 2
H bond donors: 1
Freely Rotating Bonds: 3
Polar Surface Area: 6.48Å2
Index of Refraction: 1.592
Molar Refractivity: 83.82 cm3
Molar Volume: 247.6 cm3
Surface Tension: 44 dyne/cm
Density: 1.158 g/cm3
Flash Point: 193.3 °C
Enthalpy of Vaporization: 66.12 kJ/mol
Boiling Point: 409.1 °C at 760 mmHg
Vapour Pressure: 6.66E-07 mmHg at 25°C
SMILES: Clc1ccc(cc1)C(c2ccccc2)N3CCNCC3
InChI: InChI=1/C17H19ClN2/c18-16-8-6-15(7-9-16)17(14-4-2-1-3-5-14)20-12-10-19-11-13-20/h1-9,17,19H,10-13H2
InChIKey: UZKBSZSTDQSMDR-UHFFFAOYAS
Std. InChI: InChI=1S/C17H19ClN2/c18-16-8-6-15(7-9-16)17(14-4-2-1-3-5-14)20-12-10-19-11-13-20/h1-9,17,19H,10-13H2
Std. InChIKey: UZKBSZSTDQSMDR-UHFFFAOYSA-N

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