Welcome to LookChem.com Sign In|Join Free
  • or
Home > Pharmaceutical > 104987 > 

104987-11-3

Basic Information
CAS No.: 104987-11-3
Name: Tacrolimus
Article Data: 18
Cas Database
Molecular Structure:
Molecular Structure of 104987-11-3 (Tacrolimus)
Formula: C44H69NO12
Molecular Weight: 804.031
Synonyms: 4,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-heptadecahydro-5,19-dihydroxy-3-;FK-506;FK506;15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine- 1,7,20,21(4H,23H)-tetrone,5,6,8,11,- 12,13,14,15,16,17,18,19,24,25,26,26ahexadecahydro- 5,19-dihydroxy-3-[(1E)-2- [(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]- 1-methylethenyl]-14,16-dimethoxy-4,10,12,18- tetramethyl-8-(2-propenyl)-,(3S,4R,5S,8R,- 9E,12S,14S,15R,16S,18R,19R,26aS)-;FR 900506;Prograf;dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-,(3S,4R,5S,8R,12S,14S,15R,16S,18R,19R,26aS)-;FK 506;Fujimycin;FR-900506;[(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-;Tacrolimus (FK506);Tacrolimus(FK-506);Tacrolimus(FK506);Tacrolimus, FK-506;Taccrolimus;Tacrolimus [GMP];15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(23H)-tetrone,;Prograde metamorphismPrograf;
EINECS: 1308068-626-2
Density: 1.19 g/cm3
Melting Point: 113-115 °C
Boiling Point: 871.7 °C at 760 mmHg
Flash Point: 481 °C
Solubility: DMSO: >3 mg/mL
Appearance: White or off-white crystalline powder
Hazard Symbols: ToxicT,IrritantXi
Risk Codes: 25-36/37/38
Safety: 45-36-26
Transport Information: UN 2811 6.1/PG 3
PSA: 178.36000
LogP: 4.57690
Synthetic route
118977-96-1

C56H97NO12Si2

104987-11-3

Tacrolimus

Conditions
ConditionsYield
With hydrogen fluoride In acetonitrile at 20℃; for 0.05h;100%
With hydrogen fluoride; acetonitrile In dichloromethane at 0℃; for 0.0833333h;81%
With hydrogen fluoride In acetonitrile at 20℃;81%
133941-75-0

24,33-Bis-(t.butyl-dimethylsilyl)-FK 506

104987-11-3

Tacrolimus

Conditions
ConditionsYield
With hydrogen fluoride In acetonitrile at 50℃; for 0.2h;100%
With hydrogen fluoride In acetonitrile at 20℃; for 2.5h;
128685-18-7

14-<(tert-butyldimethylsilyl)oxy>-24,32-bis<(triisopropylsilyl)oxy>-FK506

104987-11-3

Tacrolimus

Conditions
ConditionsYield
With hydrogen fluoride In acetonitrile for 18h; Ambient temperature;73%
176656-40-9

C66H101NO11Si2

104987-11-3

Tacrolimus

Conditions
ConditionsYield
With hydrogen fluoride; 3,3-dimethyldioxirane 1) acetone, CH2Cl2, -45 deg C -> -25 deg C, 1 h; -25 deg C -> 0 deg C, 1 h, 2) MeCN, 6 h; Yield given. Multistep reaction;
197250-11-6

C66H101NO12Si2

104987-11-3

Tacrolimus

Conditions
ConditionsYield
With hydrogen fluoride In acetonitrile at 20℃; for 10h; Cyclization; desilylation;10.5 mg

C55H95NO13Si2

104987-11-3

Tacrolimus

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 46 percent / epichlorohydrin / 1,2-dichloro-benzene / 0.05 h / 140 °C
2: 100 percent / aq. HF / acetonitrile / 0.2 h / 50 °C
View Scheme

{1-hydroxy-23,25-dimethoxy-12-[2-(3-methoxy-4-triethylsilanyloxy-cyclohexyl)-1-methyl-vinyl]-13,19,21,27-tetramethyl-2,3,10,16-tetraoxo-14-triethylsilanyloxy-11,28-dioxa-4-aza-tricyclo[22.3.1.04,9]octacos-18-en-17-yl}-acetaldehyde

104987-11-3

Tacrolimus

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 43 percent / epichlorohydrin / 1,2-dichloro-benzene / 0.05 h / 140 °C
2: 100 percent / aq. HF / acetonitrile / 0.05 h / 20 °C
View Scheme
197250-10-5

C69H107NO12Si2

104987-11-3

Tacrolimus

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 100 percent / dimethyl dioxirane / acetone / 2.17 h / -50 - -26 °C
2: 10.5 mg / aq. HF / acetonitrile / 10 h / 20 °C
View Scheme

C72H112INO13Si2

104987-11-3

Tacrolimus

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 110 percent / C8K-ZnCl2-AgOAc / tetrahydrofuran / 1 h / 0 °C
2: 100 percent / dimethyl dioxirane / acetone / 2.17 h / -50 - -26 °C
3: 10.5 mg / aq. HF / acetonitrile / 10 h / 20 °C
View Scheme

C72H113NO14Si2

104987-11-3

Tacrolimus

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 88 percent / triphenylphosphine; imidazole; iodine / toluene / 0.5 h / 70 °C
2: 110 percent / C8K-ZnCl2-AgOAc / tetrahydrofuran / 1 h / 0 °C
3: 100 percent / dimethyl dioxirane / acetone / 2.17 h / -50 - -26 °C
4: 10.5 mg / aq. HF / acetonitrile / 10 h / 20 °C
View Scheme
Downstream Products
3105-95-1
  • Display:default sort

    New supplier

  • Tacrolimus  FK-506  99% manufacturer in China

  • Casno:

    104987-11-3

    MSDS/COA Download

    Tacrolimus FK-506 99% manufacturer in China

    Min.Order: 1 Gram

    FOB Price:  USD $ 0.0-0.0/Gram

    CHANGZHOU HANGYU PHARMACEUTICAL TECHNOLOGY CO., LTD. founded in 1984, engages in pharmaceutical research, development, production, process design and technical consultation of synthetic pharmaceutical products. The organizational

    CHANGZHOU HANGYU PHARMACEUTICAL TECHNOLOGY CO., LTD., founded in 1984, engages in pharmaceutical research, development, production, process design and technical consultation of syn

  •  CHANGZHOU HANGYU PHARMACEUTICAL TECHNOLOGY CO., LTD

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:0086-519-88802789

    Address:No.300,Yanling Middle Road, Changzhou, Jiangsu, China

       Inquiry Now

  • Tacrolimus

  • Casno:

    104987-11-3

    Tacrolimus

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 0.0-0.0/Kilogram

    1,More than 9 years exporting experience; 2.Competitive price and quality; 3,Free sample can be provided; 4,We are sincerely responsible for the"sample quality" , "product quality" and "After Service"; 5. prompt d

    Enbridge PharmTech Co., Ltd. is an innovative company integrated with R&D, manufacturing, marketing and distribution of intermediates and fine chemicals, mainly used to pharmaceuti

  •  EnBridge PharmTech Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-510-83591909

    Address:Huishan Zone, Wuxi City, Jiangsu Province, P.R.China

       Inquiry Now

  • TIANFU-CHEM CAS:104987-11-3 Tacrolimus

  • Casno:

    104987-11-3

    TIANFU-CHEM CAS:104987-11-3 Tacrolimus

    Min.Order: 1 Gram

    FOB Price:  USD $ 0.0-0.0/Gram

    Tacrolimus Basic information Product Name: Tacrolimus Synonyms: (2-propenyl)-,(3s-(3r*(e(1s*,3s*,4s*)),4s*,5r*,8s*,9e,12r*,14r*,15s*,16r*,18s*;,19s*,26ar*))-;16-dimethoxy-4,10,12,18-tetr

    Our company engages in Electronic chemicals such as OLED,Photoresist chemical,Electrolyte additive and Intermediate Pharmaceutical production; development of noble metal catalysts,

  •  Henan Tianfu Chemical Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-371-55170693/55170694

    Address:Zhengzhou International Trade New Territory,Jinshui District,Zhengzhou ,China

       Inquiry Now

  • Tacrolimus

  • Casno:

    104987-11-3

    Tacrolimus

    Min.Order: 1 Gram

    FOB Price:  USD $ 0.0-0.0/Gram

    Tacrolimus is an immunosuppressive drug that is used mainly after allogeneic organ transplant to reduce the activity of the patient's immune system and so lower the risk of organ rejection. It is also used in a topical preparation in the

    GUANGZHOU MEDCAN PHARMATECH LTD.is a high-tech company engaged in new biopharmaceutical product development, sales, genetic engineering, bioinformatics and other areas of research

  •  GUANGZHOU MEDCAN PHARMATECH LTD

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-20-82519649

    Address:Building J,Room 101,1 JiangtashanRd,Guang Zhou Science City,Guang Zhou ,China

       Inquiry Now

  • Tacrolimus

  • Casno:

    104987-11-3

    MSDS/COA Download

    Tacrolimus

    Min.Order: 1 Gram

    FOB Price:  USD $ 0.0-0.0/Gram

    Assay:98%-102% Appearance:White or almost white crystalline powder Storage:2-8℃ Package:in bags or customer requirements Application:Immunological suppression pharmaceutical raw material Molecular Formula C44H69NO12 Molecular Weight 804.0182

    Dawn Ray is a R&D and process improvement company,which is located in Hangzhou,Zhejiang province,China. We are dealing in muti-application of pharmaceuticals(APIS),antiobics,food a

  •  Hangzhou Dawn Ray Pharmaceutical Co.,Ltd

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-571-85335020

    Address:1018 Guangyin Building,No.42 E.Fengqi Road,Hangzhou,310012 China

       Inquiry Now

  • Tacrolimus Manufacturer/High quality/Best price/In stock

  • Casno:

    104987-11-3

    Tacrolimus Manufacturer/High quality/Best price/In stock

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 3.0-3.0/Kilogram

    Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

    Dayang Chem (Hangzhou) Co.,Ltd. dedicated to the development, production and marketing of chemicals which is specialized in Organic compounds; Active Pharmaceutical Ingredi

  •  Dayang Chem (Hangzhou) Co.,Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-571-88938639

    Address:9/F, Unit 2 Changdi Torch Building, 259# WenSan Road, Xihu District, Hangzhou City 310012, P.R.China

       Inquiry Now

  • factory supply GMP,DMF,CEP Tacrolimus

  • Casno:

    104987-11-3

    factory supply GMP,DMF,CEP Tacrolimus

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 0.0-0.0/Kilogram

    We are very compeitive on Tacrolimus.Our mfr is GMP certified for this item with CEP document. Product Name: Tacrolimus CAS: 104987-11-3 MF: C44 H69 N O12 MW: 804.02 EINECS: 1308068-626-2

    Sinoway Industrial co., ltd. was established in 1987 in Xiamen, China, and now has been a leading group specialized in research, development, custom manufacturing and trading of ph

  •  Sinoway Industrial Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-592-583819

    Address:16/F,Huicheng Comm,Complex,No839 XiaHe Rd, Xiamen,China

       Inquiry Now

  • 104987-11-3 Tacrolimus global trader

  • Casno:

    104987-11-3

    104987-11-3 Tacrolimus global trader

    Min.Order: 1 Metric Ton

    FOB Price:  USD $ 2.0-2.0/Metric Ton

    GIHI CHEMICALS exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, GIHI CHEMICALS is your best choice. pls contact with us freely for getting detailed prod

    GIHI CHEMICALS CO.,LIMITED, its former company is a small manufacturer who is specialized in the production of ester products which are used in the daily chemicals ,cosmetic produc

  •  GIHI CHEMICALS CO.,LIMITED

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:571-86217390

    Address:Huacai International Building,Sandun,Westlake District,Hangzhou 310030,Zhejiang,China

       Inquiry Now

  • High purity Various Specifications Tacrolimus CAS:104987-11-3

  • Casno:

    104987-11-3

    High purity Various Specifications Tacrolimus CAS:104987-11-3

    Min.Order: 1 Gram

    FOB Price:  USD $ 100.0-500.0/Gram

    Items Standard Result Assay 98%min ----------------------------------------------------------------------------------------------

    Hangzhou Dingyan Chem Co., LTD. is located in the beautiful tourist city of hangzhou, is a comprehensive chemical enterprice which doing import and export business by its own comp

  •  Hangzhou Dingyan Chem Co., Ltd

     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:86-571-86465881,86-571-87157530,86-571-88025800

    Address:RM.1118,NO.1 Building, Baiyun Tower,Jianggan Area, Hangzhou city, China,310004

       Inquiry Now

  • Tacrolimus 104987-11-3 API

  • Casno:

    104987-11-3

    Tacrolimus 104987-11-3 API

    Min.Order: 1 Gram

    FOB Price:  USD $ 0.0-0.0/Gram

    Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu

    Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd (JL Pharm) is established in 2012 at the beautiful West Lake – Hangzhou city, China. The company's main business includes R&D, Produ

  •  Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:+86-571-85829053

    Address:Rm A606, Fuyi Center, jianqiao street, Jianggan Area

       Inquiry Now

  • Hot sales, 99% Tacrolimus

  • Casno:

    104987-11-3

    Hot sales, 99% Tacrolimus

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 11.0-16.0/Kilogram

    Hebei yanxi chemical co., LTD is a professional research, development and production . enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low carbon environmental protection

    Hebei yanxi chemical co. LTD. has expanded a compositive entity from initially only as a small manufacturer. The company dedicated to the development, production and marketing of

  •  Hebei yanxi chemical co.,LTD.

     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:86-0311-66561638

    Address:Zhang zhe, guangzong county, xingtai city, hebei province

       Inquiry Now

  • High quality Tacrolimus Cas 104987-11-3 with favorable price

  • Casno:

    104987-11-3

    High quality Tacrolimus Cas 104987-11-3 with favorable price

    Min.Order: 1 Gram

    FOB Price:  USD $ 0.0-0.0/Gram

    Unique advantages of Tacrolimus Cas 104987-11-3 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to off-white crystalline powder Storage:Cool dry place Packag

    Wuhan Fortuna Chemical Co., Ltd, located in the predominant Wu Han City where is a traffic hinge of China, is a big integrative chemical enterprise being engaged in producing and

  •  Wuhan Fortuna Chemical Co.,Ltd

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:86-27-59207852

    Address:A2705,Dong Yi Shi Qu,129# XinHua Road,WuHan,China

       Inquiry Now

  • High Quality 99% Tacrolimus 104987-11-3 GMP manufacturer

  • Casno:

    104987-11-3

    High Quality 99% Tacrolimus 104987-11-3 GMP manufacturer

    Min.Order: 1 Gram

    FOB Price:  USD $ 0.1-0.1/Gram

    1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

    Xi'an Xszo Chem Co. Ltd is a wholly-owned subsidiary of the SZO Chem Group. SZO Group is composed of Xi'an Xszo Chem Co. Ltd & Shaanxi SZO Tech Co., Ltd. SZO industry Group have mo

  •  Xi'an Xszo Chem Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:+86-029-88698540

    Address:No.16,Jingqin Rd. JingWei Industrial park,Shaanxi,China,710200

       Inquiry Now

  • Tacrolimus

  • Casno:

    104987-11-3

    Tacrolimus

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 0.0-0.0/Kilogram

    T he company has advanced technology, as well as a large number of excellent R & D team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, competitive prices and quality service Appearance:white

    Located in Zhengdong New District,?Zhengzhou of Henan province, Henan Allgreen Chemical Co.,Ltd is a comprehensive high-tech modern enterprises integrating professional R&D, pro

  •  Henan Allgreen Chemical Co.,Ltd

     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:+86-0371-87507775

    Address:No 260 Dongming Road,Jinshui District

       Inquiry Now

  • High Quality CAS 104987-11-3 Tacrolimus Powder

  • Casno:

    104987-11-3

    MSDS/COA Download

    High Quality CAS 104987-11-3 Tacrolimus Powder

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 50.0-90.0/Kilogram

    We promise our customer following items: 1.Support product customization: We can provide OEM&ODM , Because we have a professional design team 2.Reasonable price: We provide high quality products with competitive price in china, 3.Low moq: No

    Xi'an Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged in the research, development, production and sales of S

  •  Xi'an Julong Bio-Tech Co., Ltd.

    China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+008618049624045

    Address:Xi'an

       Inquiry Now

  • Factory Supply Tacrolimus

  • Casno:

    104987-11-3

    Factory Supply Tacrolimus

    Min.Order: 1

    FOB Price:  USD $ 0.0-0.0/

    The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

    Ality Chemical, established in 2007, is a comprehensive Chemical Production&Supply Group with Patent Technology as its core. Ality Chemical operates sales branches in Shanghai, Xia

  •  Ality Chemical Corporation

     China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:0513-87616220

    Address:Fine chemical industry park, Nantong,Jiangsu

       Inquiry Now

  • 98% min Tacrolimus powder with factory price CAS 104987-11-3

  • Casno:

    104987-11-3

    98% min Tacrolimus powder with factory price CAS 104987-11-3

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 40.0-40.0/Kilogram

    Before-Sale Service: ---Any inquiries will be replied within 12 hours. ---Golden Manufactory under ISO/GMP with large stock. ---Dedication to quality,We have strict quality control system. ---OEM/ODM Available. ---Sample is available for your evalua

    Xi'an Harmonious Natural Bio-Technology Co., Ltd. was founded in 2010, and located in Xian International Logistics Industrial Zone, Xi'an City, Shaanxi Province, China. Now it is

  •  Xi'an Harmonious Natural Bio-Technology Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-18092068319

    Address:huilinhuacheng 10-2104

       Inquiry Now

  • Tacrolimus

  • Casno:

    104987-11-3

    Tacrolimus

    Min.Order: 10 Milligram

    FOB Price:  USD $ 0.0-0.0/Milligram

    1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

    Founded in 2011, Amadis Chemical Company Limited is an innovative manufacturer of chemical products and technical service providers. Our business includes sales, manufacture, and s

  •  Amadis Chemical Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-571-89925085

    Address:Watts Cosine.No.166.Xiangmao Road.

       Inquiry Now

  • TOP quality Tacrolimus 104987-11-3 with best price

  • Casno:

    104987-11-3

    TOP quality Tacrolimus 104987-11-3 with best price

    Min.Order: 0 Metric Ton

    FOB Price:  USD $ 0.0-0.0/Metric Ton

    TOP quality Tacrolimus 104987-11-3 with best price TAIHO Unique Advantages: 1.We're factory 2.Free samples available 3.Commodity inspection can be done 4.ISO9001,Kosher certifications 5.10 years experiences Appearance:White powde Storage:Store i

    As a member of TAIHO Group,Hubei Taiho Chemical Co.,Ltd,is a professional new-type chemicals enterprise combined into research and development,production and sales.We adhere to the

  •  Hubei Taiho Chemical Co.,LTD

     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:+86-18120399543

    Address:No. 49 taifeng Road,Qianjiang City,Hubei,China

       Inquiry Now

  • Tacrolimus

  • Casno:

    104987-11-3

    Tacrolimus

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 5.0-5.0/Kilogram

    Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

    Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,an

  •  Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:0086-317-5105699

    Address:40# Shuiyuesi Street, Cangzhou City,Hebei Province, China.

       Inquiry Now

  • Tacrolimus

  • Casno:

    104987-11-3

    Tacrolimus

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 1.0-1.0/Kilogram

    ITEM SPECIFICATION Assay: ≥99.5% Heavy Metals ≤10ppm Arsenic ≤1ppm Lead ≤3ppm Mercury ≤0.1ppm

    Welcome to Henan Sinotech! Sinotech Corporation has exceptional sourcing ability for chemicals used in Organic Fine Chemicals and APIs; Inorganic chemicals; Flame Retardants; Rubb

  •  Henan Sinotech Import&Export Corporation

     China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:86-371-86181678

    Address:No. 260, Dongming Road,Jinshui District

       Inquiry Now

  • Cheap Tacrolimus 99% 50KG in stock

  • Casno:

    104987-11-3

    Cheap Tacrolimus 99% 50KG in stock

    Min.Order: 1 Gram

    FOB Price:  USD $ 0.0-0.0/Gram

    TianYuan Pharmaceutical Co.,Limited was established in December 2009 for Hongkong. We are a leading high-tech enterprise expertised in researching, developing and manufacturing innovative and generic drugs on anticancer, anti-HIV, anti-tumor, an

    Tianyuan pharmaceutical company in Zhangjiang Eastern has built 500 square meters of pilot laboratories, equipped with two sets of 50L glass reactor, four sets of 100L double react

  •  Shenzhen Tianyuan Pharmaceutical Technology Co., Ltd

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-755-23284190

    Address:B302,2 unit, Jin Lian Building, No. 134 Qianjin 2 Road, Taoyuan village, Xixiang Street, Baoan,Shenzhen,China

       Inquiry Now

  • Tacrolimus

  • Casno:

    104987-11-3

    Tacrolimus

    Min.Order: 1 Gram

    FOB Price:  USD $ 1.0-1.0/Gram

    Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&

    LIDE PHARMACEUTICALS LIMITED is one of the fastest growing pharmaceutical company in China. We have developed strategic partnership with our manufacturing associates having state o

  •  LIDE PHARMACEUTICALS LIMITED

    China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-25-58409506

    Address:11F, Building A1, No.288 North Zhongshan Road, Gulou District, Nanjing,210003, P.R.China.

       Inquiry Now

  • Tacrolimus Manufacturer 104987-11-3 Rejection For Organ Transplantation

  • Casno:

    104987-11-3

    Tacrolimus Manufacturer 104987-11-3 Rejection For Organ Transplantation

    Min.Order: 10 Gram

    FOB Price:  USD $ 0.0-0.0/Gram

    Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s

    Hubei Xinrunde Chemical Co., Ltd. dedicated to the development, production and marketing of chemicals which is specialized in Organic compounds; Active Pharmaceutical Ingredient(s)

  •  Hubei XinRunde Chemical Co., Ltd

     China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:+8615102730682

    Address:No.43, Xinandu Industrial Park, East and West Lake District, Wuhan, Hubei, China

       Inquiry Now

  • high quality104987-11-3 Tacrolimus with best price

  • Casno:

    104987-11-3

    high quality104987-11-3 Tacrolimus with best price

    Min.Order: 10 Gram

    FOB Price:  USD $ 1.0-2.0/Gram

    1,Best Quality: Our products have exported to Germany, Spain, UK, USA, Australia, Middle East, and so on other countries, and we have got very good feedback from our customers.so

    Hubei Jusheng Technology Co., Ltd., is a large group corporation which engaged in the R&D and manufacture of chemicals, Pharmaceuticals and intermediates. We have earned ourselves

  •  Hubei Jusheng Technology Co., Ltd.,

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-18871490254

    Address:High-tech Industrial Park,Tianmen city,Hubei province.

       Inquiry Now

  • Pharmaceutical Grade CAS 104987-11-3 with competitive price

  • Casno:

    104987-11-3

    Pharmaceutical Grade CAS 104987-11-3 with competitive price

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 139.0-210.0/Kilogram

    WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

    Zhuo Zhou Wen Xi Import and Export Co., Ltd. is a company mainly engaged in the export of pharmaceutical raw materials. Its parent company is (Wen Xi Pharma), including three subs

  •  Zhuozhou Wenxi import and Export Co., Ltd

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-13111626072

    Address:Room 1710, Baoxin International Phase I, 19 Guanyun East Road, Zhuozhou, Hebei

       Inquiry Now

  • BLOOM TECH Advanced API/Technology support Tacrolimus CAS 104987-11-3

  • Casno:

    104987-11-3

    MSDS/COA Download

    BLOOM TECH Advanced API/Technology support Tacrolimus CAS 104987-11-3

    Min.Order: 1 Gram

    FOB Price:  USD $ 0.0-0.0/Gram

    Inquiry guide 1.Please send the quantity(Weight) to us, we will arrange our sales to provide the one-for-one service for you. 2.Then we will provide the professional quotation list for you, it will be including all the factors in who

    WHO WE ARE 1.We Focus on the technology of Organic Synthesis since 2008. 2.API/Pharmaceutical intermediate/Fine chemical/New material/Extraction etc. 3.Chemical reagent: Over 300,0

  •  Shaanxi BLOOM TECH Co.,Ltd

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-29-86470566

    Address:Block A of Central Mansion, No.113 of Weiyang Rd, ETDZ, Xi'an, Shaanxi 710016, China

       Inquiry Now

  • Good supply Tacrolimus Manufacture

  • Casno:

    104987-11-3

    MSDS/COA Download

    Good supply Tacrolimus Manufacture

    Min.Order: 10 Gram

    FOB Price:  USD $ 0.0-0.0/Gram

    Tacrolimus CAS:104987-11-3 Test Items Standards Test Results Character Off-white to white powder conform M

    HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketi

  •  Hangzhou Think Chemical Co. Ltd

     China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:86-571-89986307/81956191/81956084/81956192

    Address:Room 719 Building D Meidu Plaza 789 Moganshan Road

       Inquiry Now

  • Tacrolimus FK-506 99% manufacturer in China

  • Casno:

    104987-11-3

    Tacrolimus FK-506 99% manufacturer in China

    Min.Order: 25 Kilogram

    FOB Price:  USD $ 1.0-2.0/Kilogram

    Name:Tacrolimus CAS:104987-11-3 Grade:For chemical industry, scientific research and export Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerability P

    Hubei DiBo chemical co., LTD Hubei DiBo Chemical Co., Ltd. was founded in 2009, is located in Hubei Province on both sides of the Yangtze River, one of the ancient cities of Chines

  •  Hubei DiBo chemical co., LTD

     China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:+86 15871366807

    Address:No. 782 of wuchang district of wuhan city, hubei province

       Inquiry Now

  • Manufacturer of Tacrolimus at Factory Price

  • Casno:

    104987-11-3

    Manufacturer of Tacrolimus at Factory Price

    Min.Order: 25 Kilogram

    FOB Price:  USD $ 0.0-0.0/Kilogram

    1. We are one of the domestic largest manufacturers of API; 2. We are always the supplier of products with higher quality and at more competitive price; 3. We are supplier of safe and ecofriendly products ; 4. We provide stable supply and

    TNJ is a chemical company since 2001. Our specialization, your confidence-we keep committing to meet the needs of markets and customers with our innovative technology and high stab

  •  Hefei TNJ chemical industry co.,ltd

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-551-65418695

    Address:B911 Xincheng Business Center, Qianshan Road, Hefei Anhui China

       Inquiry Now

  • Tacrolimus FK-506 with lower price

  • Casno:

    104987-11-3

    Tacrolimus FK-506 with lower price

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 1.0-1.0/Kilogram

    1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical intermediate

    Shanghai Upbio Tech Co.,Ltd (Former Onchem (China)Co.,Ltd) is a comprehensive manufacturer and an international distribution of chemicals throughout the world, The predecessor of

  •  Shanghai Upbio Tech Co.,Ltd

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-21-52196435

    Address:No.2 Floor,No.979 Yunhan Rd,Nicheng,Pudong New Area,Shanghai,China

       Inquiry Now

  • High purityTacrolimus 104987-11-3 CAS 99% ready stock

  • Casno:

    104987-11-3

    High purityTacrolimus 104987-11-3 CAS 99% ready stock

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 0.0-0.0/Kilogram

    Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Appearance:White powder / Refer to COA Storage:?20°C Packa

    Our company was funded in 2018. In order to adapt to the trend of world development, we established B2B e-commerce sector in Hangzhou. We supply raw material of chemicals, like API

  •  Hangzhou Fonlynn Health Technology Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:86 15868163694

    Address:Room 622, Building 11, Yifeng City, Nanyuan Street, Yuhang District

       Inquiry Now

  • Tacrolimus CAS :104987-11-3 is used for immunosuppression

  • Casno:

    104987-11-3

    Tacrolimus CAS :104987-11-3 is used for immunosuppression

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 3.0-10.0/Kilogram

    With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

    Our company specializes in processing and selling chemical raw materials, chemical th Asia, Europe, America, Africa and other more than 20 countries and regions. ? Companies adheri

  •  Hebei Nengqian Chemical Import and Export Co. LTD

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86 13910575315

    Address:hebei

       Inquiry Now

  • Tacrolimus

  • Casno:

    104987-11-3

    Tacrolimus

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 80.0-100.0/Kilogram

    Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

    Baoji Guokang Healthchem co.,ltd located in Baoji High-tech Zone,is epitomizing international,cooperative and honest.We are a young company full of action and energy,and our profes

  •  Baoji Guokang Healthchem co.,ltd

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:86-917-3909592

    Address:China

       Inquiry Now

Please post your buying leads,so that our qualified suppliers will soon contact you!
*Required Fields

History

 Tacrolimus (CAS NO.104987-11-3) was among the first macrolide immunosuppressants discovered, which was discovered in 1984 by a Japanese team headed by T. Goto, T. Kino and H. Hatanaka. The name tacrolimus is derived from 'Tsukuba macrolide immunosuppressant'. Tacrolimus is owned by Astellas Pharma Inc., and is sold under the tradenames Prograf, Advagraf, and Protopic. It was first approved by the Food and Drug Administration (FDA) in 1994 use in liver transplantation, trachea, skin, cornea, and limb transplants.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal > 200mg/kg (200mg/kg)   Journal of Antibiotics. Vol. 40, Pg. 1249, 1987.

Specification

The Tacrolimus, with the CAS registry number 104987-11-3,is also known as Tsukubaenolide. It belongs to the product categories of Pharmaceuticals; API;Chiral Reagents.Its EINECS number is 242-042-4. This chemical's molecular formula is C44H69NO12 and molecular weight is 804.02. What's more,Its systematic name is 15,19-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone.It is a White Crystalline Solid which is used after allogeneic organ transplant to reduce the activity of the patient's immune system and so lower the risk of organ rejection. In recent years, it has been used to suppress the inflammation associated with ulcerative colitis. It is a recent addition in the treatment of eczema, particularly atopic dermatitis, and suppresses inflammation in a similar way to steroids.

Physical properties about Tacrolimus are:
(1)ACD/LogP:  3.96; (2)# of Rule of 5 Violations:  2; (3)ACD/LogD (pH 5.5):  3.96; (4)ACD/LogD (pH 7.4):  3.96; (5)ACD/BCF (pH 5.5):  602.10; (6)ACD/BCF (pH 7.4):  600.47; (7)ACD/KOC (pH 5.5):  3398.48; (8)ACD/KOC (pH 7.4):  3389.29; (9)#H bond acceptors:  13; (10)#H bond donors:  3; (11)#Freely Rotating Bonds:  10; (12)Index of Refraction:  1.549; (13)Molar Refractivity:  214.131 cm3; (14)Molar Volume:  673.124 cm3; (15)Surface Tension:  51.2929992675781 dyne/cm; (16)Density:  1.194 g/cm3; (17)Flash Point:  481 °C; (18)Enthalpy of Vaporization:  143.946 kJ/mol; (19)Boiling Point:  871.721 °C at 760 mmHg; (20)Vapour Pressure:  0 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES:O=C3C(=O)N1CCCC[C@H]1C(=O)O[C@H](C(=C/[C@@H]2CC[C@@H](O)[C@H](OC)C2)/C)[C@H](C)[C@@H](O)CC(=O)[C@@H](/C=C(\C[C@@H](C[C@H](OC)[C@H]4O[C@]3(O)[C@H](C)C[C@@H]4OC)C)C)C\C=C;
(2)Std. InChI:InChI=1S/C44H69NO12/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3/b25-19+,27-21+/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+/m0/s1;
(3)Std. InChIKey:QJJXYPPXXYFBGM-LFZNUXCKSA-N.

The toxicity data of Tacrolimus are as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal > 200mg/kg (200mg/kg)   Journal of Antibiotics. Vol. 40, Pg. 1249, 1987.