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Name	(S)-(-)-2-Acetoxypropionyl chloride	EINECS	420-610-4
CAS No.	36394-75-9	Density	1.22 g/cm³
PSA	43.37000	LogP	0.70340
Solubility	N/A	Melting Point	N/A
Formula	C₅H₇ClO₃	Boiling Point	163.862 °C at 760 mmHg
Molecular Weight	150.562	Flash Point	62.593 °C
Transport Information	UN 3265 8/PG 2	Appearance	Colorless fuming liquids
Safety	26-36/37/39-45	Risk Codes	34
Molecular Structure		Hazard Symbols	C
Synonyms	Propanoylchloride, 2-(acetyloxy)-, (S)-;(1S)-2-Chloro-1-methyl-2-oxoethyl acetate;(S)-2-(Acetyloxy)propanoyl chloride;(S)-2-Acetoxypropanoyl chloride;(S)-2-Acetoxypropionyl chloride;Acetic acid(1S)-1-(chlorocarbonyl)ethyl ester;Acetic acid(1S)-2-chloro-1-methyl-2-oxoethyl ester;L-a-Acetoxypropionyl chloride;	Article Data	27

(S)-(-)-2-Acetoxypropionyl chloride Synthetic route

: 535-17-1, 3853-80-3, 18668-00-3, 6034-46-4
(S)-2-acetoxypropionic acid

: 36394-75-9
(S)-2-acetoxypropanoyl chloride

Conditions

Conditions	Yield
With thionyl chloride at 50℃; for 2h;	93.7%
With thionyl chloride at 20℃; Chlorination;	31%
With thionyl chloride

: 867-56-1
sodium L-lactate

: 75-36-5
acetyl chloride

: 36394-75-9
(S)-2-acetoxypropanoyl chloride

Conditions

Conditions	Yield
With hydrogenchloride; thionyl chloride In diethyl ether	64%

: 867-56-1
sodium L-lactate

: 36394-75-9
(S)-2-acetoxypropanoyl chloride

: C7H10O5

: 36394-75-9
(S)-2-acetoxypropanoyl chloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrogenchloride / water / 0.25 h / 20 - 40 °C 2: thionyl chloride / 1,2-dichloro-ethane / 7 h / 40 °C View Scheme

: 79-37-8
oxalyl dichloride

: 79-33-4
L-Lactic acid

: 75-36-5
acetyl chloride

: 36394-75-9
(S)-2-acetoxypropanoyl chloride

Conditions

Conditions	Yield
In dichloromethane

: 79-33-4
L-Lactic acid

: 75-36-5
acetyl chloride

: 36394-75-9
(S)-2-acetoxypropanoyl chloride

Conditions

Conditions	Yield
Stage #1: L-Lactic acid; acetyl chloride at 20℃; Schlenk technique; Inert atmosphere; Stage #2: With thionyl chloride In N,N-dimethyl-formamide at 20℃; Schlenk technique; Inert atmosphere;

: 1220700-96-8
C22H21N7O

: 36394-75-9
(S)-2-acetoxypropanoyl chloride

: 1220700-97-9
C27H27N7O4

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 1h; Inert atmosphere;	100%

: (3S,4R)-tert-butyl 3-((((R)-(1-benzyl-4-(2,5-difluorophenyl)-1H-imidazol-2-yl)(tetrahydro-2H-pyran-4-yl)methyl)amino)methyl)-4-((tert-butyldimethylsilyl)oxy)pyrrolidine-1-carboxylate

: 36394-75-9
(S)-2-acetoxypropanoyl chloride

: (3S,4R)-tert-butyl 3-(((S)-2-acetoxy-N-((R)-(1-benzyl-4-(2,5-difluorophenyl)-1H-imidazol-2-yl)(tetrahydro-2H-pyran-4-yl)methyl)propanamido)methyl)-4-((tert-butyldimethylsilyl)oxy)pyrrolidine-1-carboxylate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 1.5h;	100%

: 61586-78-5
ethyl (1R,2S)-2-hydroxycyclohexane-1-carboxylate

: 36394-75-9
(S)-2-acetoxypropanoyl chloride

: (1R,2S)-2-((S)-2-Acetoxy-propionyloxy)-cyclohexanecarboxylic acid ethyl ester

Conditions

Conditions	Yield
With pyridine In diethyl ether at 4℃; for 20h; Acylation;	99%

: [5,6-bis-(trimethyl-silanyloxy)-1,2,3,4,5,6-hexahydro-inden-3a-yl]-methanol

: 36394-75-9
(S)-2-acetoxypropanoyl chloride

: 2-acetoxypropionic acid 5,6-bis(trimethyl-silanyloxy)-1,2,3,4,5,6-hexahydro-1H-inden-3a-yl methyl ester

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 0℃; for 0.416667h;	99%

(S)-(-)-2-Acetoxypropionyl chloride Chemical Properties

Molecular Structure of Propanoyl chloride,2-(acetyloxy)-, (2S)- (CAS No.36394-75-9):

Molecular Formula: C₅H₇ClO₃
Molecular Weight: 150.56
CAS No: 36394-75-9
Density: 1.189 g/cm3
Boiling point: 50 ºC (5 mmHg)
Refractive index: 1.423
Flash point: 113 ºC

(S)-(-)-2-Acetoxypropionyl chloride Safety Profile

Hazard Codes: Corrosive C
Risk Statements: 34
R34:Causes burns.
Safety Statements: 26-36/37/39-45
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 3265 8/PG 2
WGK Germany: 3
F: 10-21
HazardClass: 8
PackingGroup: III

(S)-(-)-2-Acetoxypropionyl chloride Specification

Propanoyl chloride,2-(acetyloxy)-, (2S)- (CAS No.36394-75-9), its synonyms are (S)-(-)-O-Acetyllactoyl chloride ; (S)-(-)-2-Acetoxypropionyl chloride ; (S)-2-Acetoxypropionyl chloride ; S-Acetoxypropionyl chloride ; O-Acetyl-l-lactyl chloride ; 2-Acetoxy propionyl chloride;L-(-)-2-Acetoxypropionyl chloride .

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