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| Name |
1-(m-Trifluoromethylphenyl)-3-(2'-hydroxyethyl)quinazoline-2,4-dione |
EINECS | N/A |
| CAS No. | 34929-08-3 | Density | 1.434g/cm3 |
| PSA | 64.23000 | LogP | 2.16350 |
| Solubility | N/A | Melting Point |
N/A |
| Formula | C17H13 F3 N2 O3 | Boiling Point | 490°Cat760mmHg |
| Molecular Weight | 350.297 | Flash Point | 250.1°C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Poison by ingestion and intraperitoneal routes. When heated to decomposition it emits very toxic fumes of F− and NOx. See also FLUORIDES. | Risk Codes | N/A |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
H 88; H 88(antiinflammatory) |
1-(m-Trifluoromethylphenyl)-3-(2'-hydroxyethyl)quinazoline-2,4-dione Chemical Properties
IUPAC Name: 3-(2-Hydroxyethyl)-1-[3-(trifluoromethyl)phenyl]quinazoline-2,4-dione
Synonyms: 1-(m-Trifluoromethylphenyl)-3-(2-hydroxyethyl)-quinazoline-2,4(1H,3H)-dione ; 1-(m-Trifluoromethylphenyl)-3-(2'-hydroxyethyl)quinazoline-2,4-dione ; 2,4(1H,3H)-Quinazolinedione, 3-(2-hydroxyethyl)-1-(m-(trifluoromethyl)phenyl)- ; -(2-Hydroxyethyl)-1-(3-(trifluoromethyl)phenyl)-2,4(1H,3H)-quinazolinedione
CAS NO:34929-08-3
Molecular Formula of 1-(m-Trifluoromethylphenyl)-3-(2'-hydroxyethyl)quinazoline-2,4-dione (CAS NO:34929-08-3) : C17H13F3N2O3
Molecular Weight of 1-(m-Trifluoromethylphenyl)-3-(2'-hydroxyethyl)quinazoline-2,4-dione (CAS NO:34929-08-3) :350.2919
Molecular structure of 1-(m-Trifluoromethylphenyl)-3-(2'-hydroxyethyl)quinazoline-2,4-dione (CAS NO:34929-08-3) :
Index of Refraction: 1.582
Surface Tension: 49.7 dyne/cm
Density: 1.434 g/cm3
Flash Point: 250.1 °C
Enthalpy of Vaporization: 79.66 kJ/mol
Boiling Point: 490 °C at 760 mmHg
Vapour Pressure: 2.05E-10 mmHg at 25°C
1-(m-Trifluoromethylphenyl)-3-(2'-hydroxyethyl)quinazoline-2,4-dione Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | oral | > 2gm/kg (2000mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 501, 1978. |
| guinea pig | LD50 | oral | 320mg/kg (320mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 501, 1978. | |
| hamster | LD50 | oral | > 2gm/kg (2000mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 501, 1978. |
| mouse | LD50 | intraperitoneal | 200mg/kg (200mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) GASTROINTESTINAL: MALABSORPTION | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 70, Pg. 673, 1974. |
| mouse | LD50 | oral | 630mg/kg (630mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 501, 1978. |
| rabbit | LD50 | oral | > 2500mg/kg (2500mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 501, 1978. |
| rat | LD50 | intraperitoneal | 152mg/kg (152mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) GASTROINTESTINAL: MALABSORPTION | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 70, Pg. 673, 1974. |
| rat | LD50 | oral | 810mg/kg (810mg/kg) | Drugs of the Future. Vol. 4, Pg. 201, 1979. | |
| rat | LD50 | subcutaneous | > 2gm/kg (2000mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 501, 1978. |
1-(m-Trifluoromethylphenyl)-3-(2'-hydroxyethyl)quinazoline-2,4-dione Safety Profile
Poison by ingestion and intraperitoneal routes. When heated to decomposition it emits very toxic fumes of F− and NOx. See also FLUORIDES.
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