- 10,10'-Bis([1,1'-biphenyl]-4-yl)-9,9'-bianthracene
- 10,10'-Dibromo-9,9'-bianthryl
- 10,10-Dimethylanthrone
- 10,10-Oxybisphenoxarsine
- 10-[1,1'-Biphenyl]-4-yl-2-(1-methylethyl)-9-oxo-9H-thioxanthenium hexafluorophosphate
- 10,11-Dehydroimipramine
- 10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine
- 10,11-Dihydro-2-(4-methyl-1-piperazinyl)-11-(2-athiazolyl)-pyridazino(3,4-b)(1,4)benzoxazepine
- 10,11-DIHYDRO-2-(4-METHYL-1-PIPERAZINYL)-11-(3,4-XYLYL)PYRIDAZINO(3,4b)(1,4)-BENZOXAZEPINE MALEATE
- 10,11-Dihydro-5-(3-dimethylamino-2-methylpropyl)-5h-dibenz (b,f)azepine
- 6378-88-7Benzo[a]phenazinium,7-phenyl-5,9-bis(phenylamino)-4,10-disulfo-, inner salt, sodium salt (1:1)
- 6378-89-8Benzo[a]phenazinium,5-[[4-(diethylamino)-3-sulfophenyl]amino]-9-[ethyl[(3-sulfophenyl)methyl]amino]-7-phenyl-,inner salt, sodium salt (1:1)
- 637-89-84-Mercaptophenol
- 6379-01-75H-Benzo[a]phenothiazine-2-sulfonicacid, 9-(dimethylamino)-6-hydroxy-5-oxo-, sodium salt(1:1)
- 637-91-2Propanal,2,2-dimethyl-, oxime
- 637-92-3Propane,2-ethoxy-2-methyl-
- 63793-60-2Poly[oxy(methyl-1,2-ethanediyl)],a-tetradecyl-w-hydroxy-
- 6379-73-3Benzene,2-methoxy-1-methyl-4-(1-methylethyl)-
- 637-97-8Pentane, 2-iodo-
- 63798-15-2SRI Oxime V (9CI)
Hot Products
- 6380-71-8DODECYL 3-MERCAPTOPROPIONATE
- 6381-59-5Potassium sodium tartrate tetrahydrate
- 638-21-1Phenyl phosphine
- 63843-89-0Bis(1,2,2,6,6-pentamethyl-4-piperidyl) [[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methyl]butylmalonate
- 638-53-9Tridecanoic acid
- 63884-91-3N-(2-Chloroethyl)-N-nitrosocarbamic acid butyl ester
- 63905-13-5N'-(isopropyl)-N,N-dimethylpropane-1,3-diamine
- 63950-87-8RALUFON (R) NO 14
- 104987-11-3Tacrolimus
- 141-53-7Sodium formate
- 8001-54-5Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
- 9003-39-8Povidone
- 10161-34-9Trenbolone acetate
- 402957-28-2Telaprevir
- 68-19-9Cyanocobalamin
|
Basic Information |
|
Post buying leads |
|
Suppliers |
|
Cas Database |
| Name |
1,4-Cyclohexanedione |
EINECS | 211-306-0 |
| CAS No. | 637-88-7 | Density | 1.128 g/cm3 |
| PSA | 34.14000 | LogP | 0.69860 |
| Solubility | N/A | Melting Point |
77-78.5 °C(lit.) |
| Formula | C6H8O2 | Boiling Point | 226.66 °C at 760 mmHg |
| Molecular Weight | 112.128 | Flash Point | 82.157 °C |
| Transport Information | N/A | Appearance | tan or yellow crystalline powder |
| Safety | 22-24/25 | Risk Codes | N/A |
| Molecular Structure |
|
Hazard Symbols |
 Xi
|
| Synonyms |
1,4-Dioxocyclohexane;Tetrahydroquinone;Cyclohexan-1,4-dione;1,4-Cyclohexane Dione;1,4-Cyclohexanedione(CAS:637-88-7); |
Article Data | 110 |
1,4-Cyclohexanedione Synthetic route
| Conditions | Yield |
|---|---|
| With aluminium trichloride; zinc In tetrahydrofuran for 0.4h; Ambient temperature; | 100% |
| With formic acid In toluene at 120℃; for 10h; Inert atmosphere; chemoselective reaction; | 57% |
| With hydrogen; tetra-(n-butyl)ammonium iodide In water at 110℃; under 15001.5 Torr; for 24h; chemoselective reaction; | 57% |
| With ruthenium; hydrogen at 80℃; under 37503.8 Torr; for 1h; Reagent/catalyst; Ionic liquid; chemoselective reaction; |
- 10553-38-5
1,4-cyclohexanedione bis(dimethyl acetal)
- 637-88-7
1,4-Cyclohexanedione
| Conditions | Yield |
|---|---|
| In 1,4-dioxane; water; dimethyl sulfoxide for 12h; Heating; | 98.2% |
| Conditions | Yield |
|---|---|
| With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In neat (no solvent) at 20℃; for 1h; Milling; | 97% |
| With ruthenium(IV) oxide; sodium dihydrogenphosphate; sodium chloride In water at 10 - 15℃; electrooxidation; | 94% |
| With m-iodosylbenzoic acid; ruthenium trichloride In water; acetonitrile at 20℃; for 10h; | 84% |
| Conditions | Yield |
|---|---|
| With barium(II) chloride In water at 19.85 - 179.85℃; under 7575.61 Torr; for 0.666667h; | 96% |
| With CuCl2*2H2O In acetonitrile for 0.5h; Ambient temperature; | 95% |
| With trifluoroacetic acid In dichloromethane at 25℃; for 12h; | 90% |
| Conditions | Yield |
|---|---|
| With sodium bromate; sodium hydrogensulfite In water; acetonitrile at 20℃; for 6h; Oxidation; | A 1% B 93% |
| With sodium bromate; sodium hydrogensulfite In water; acetonitrile at 20℃; for 2h; Oxidation; | A 78% B 10% |
| With 2O34W9Zn(12-)*W(6+)*3Zn(2+)*2H2O; dihydrogen peroxide In water; acetonitrile at 135℃; under 2250.23 Torr; for 0.25h; Microwave irradiation; | A n/a B 58% |
- 67-51-6
3,5-dimethyl-1H-pyrazole
A
- 4746-97-8
cyclohexanedione monoethylene ketal
B
- 637-88-7
1,4-Cyclohexanedione
| Conditions | Yield |
|---|---|
| In dichloromethane; ethyl acetate | A 91% B n/a |
- 26757-29-9
1,4-Cyclohexandion-bis-(dimethylhydrazon)
- 637-88-7
1,4-Cyclohexanedione
| Conditions | Yield |
|---|---|
| With dihydrogen peroxide; methyltrioxorhenium(VII) In acetic acid; acetonitrile at 0 - 20℃; Product distribution; oxidative cleavage; | 88% |
- 13482-22-9
4-hydroxycyclohexanone
- 637-88-7
1,4-Cyclohexanedione
| Conditions | Yield |
|---|---|
| With pyridinium chlorochromate In dichloromethane for 2h; Ambient temperature; | 87% |
- 87377-98-8, 87398-13-8, 190020-19-0
(Z,Z)-1,4-Cyclohexandion-bis
- 637-88-7
1,4-Cyclohexanedione
| Conditions | Yield |
|---|---|
| With hydrogenchloride In dichloromethane for 12h; Ambient temperature; | 87% |
| Conditions | Yield |
|---|---|
| With tetrachlorosilane In dichloromethane at 20℃; for 0.5h; | 85% |
1,4-Cyclohexanedione Chemical Properties
The Molecular Structure of 1,4-Cyclohexanedione (CAS NO.637-88-7):
Empirical Formula: C6H8O2
Molecular Weight: 112.1265
Nominal Mass: 112 Da
Average Mass: 112.1265 Da
Monoisotopic Mass: 112.052429 Da
Index of Refraction: 1.473
Molar Refractivity: 27.93 cm3
Molar Volume: 99.4 cm3
Surface Tension: 40.5 dyne/cm
Density: 1.127 g/cm3
Flash Point: 82.2 °C
Enthalpy of Vaporization: 46.32 kJ/mol
Boiling Point: 226.7 °C at 760 mmHg
Vapour Pressure: 0.0809 mmHg at 25°C
Melting Point: 76-80°C
IUPAC Name: cyclohexane-1,4-dione
Appearance: tan or yellow crystalline powder
Synonyms: 1,4-Cyclohexanedion;1,4-Dioxocyclohexane;Tetrahydroquinone;Tetrahydro-p-benzoquinone;1,4-Cyclohexandione;1,4-Tetrahydroquinone;Cyclohexane-1,4-dione;CHD
Product Categories: ketone;Pharmaceutical Intermediate;C3 to C6;Carbonyl Compounds;Ketones
1,4-Cyclohexanedione History
1,4-Cyclohexanedione (CAS NO.637-88-7) is prepared in two steps from diesters of succinic acid. For example under basic conditions, the diethyl ester condenses to give 2,5-dicarbethoxy-1,4-cyclohexanedione. This intermediate can be hydrolysed and decarboxylated to afford the desired dione.
1,4-Cyclohexanedione Uses
1,4-Cyclohexanedione (CAS NO.637-88-7) is used as a building block in the synthesis of more complex molecules.
1,4-Cyclohexanedione Production
1,4-Cyclohexanedione (CAS NO.637-88-7) is prepared in two steps from diesters of succinic acid.Under basic conditions, the diethyl ester condenses to give 2,5-dicarbethoxy-1,4-cyclohexanedione. This intermediate can be hydrolysed and decarboxylated to afford the desired dione.
1,4-Cyclohexanedione Safety Profile
Hazard Codes: 
Xi
Safety Statements: 22-24/25
S22:Do not breathe dust
S24/25:Avoid contact with skin and eyes
WGK Germany: 3
F: 8
Hazard Note: Irritant
HS Code: 29142900
Do not breathe the dust of 1,4-Cyclohexanedione (CAS NO.637-88-7). Avoid 1,4-Cyclohexanedione (CAS NO.637-88-7) contact with skin and with eyes.
1,4-Cyclohexanedione Specification
1,4-Cyclohexanedione (CAS NO.637-88-7) is the organic compound. This colourless solid is one of the three isomeric cyclohexanediones. This particular diketone is used as a building block in the synthesis of more complex molecules.
What can I do for you?
Get Best Price
