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| CAS No.: | 1072-52-2 |
|---|---|
| Name: | 1-Aziridineethanol |
| Molecular Structure: | |
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| Formula: | C4H9 N O |
| Molecular Weight: | 87.1216 |
| Synonyms: | 1-(2-Hydroxyethyl)ethylenimine;1-(2-Hydroxylethyl)aziridine; 2-(Aziridin-1-yl)ethanol;N-(2-Hydroxyethyl)aziridine; N-(2-Hydroxyethyl)ethylenimine; N-(b-Hydroxyethyl)aziridine; NSC50209 |
| Density: | 1,088 g/cm3 |
| Boiling Point: | 167-168°C |
| Flash Point: | 67°C |
| Appearance: | CLEAR COLOURLESS LIQUID |
| Hazard Symbols: | Irritant to skin and eyes. |
| Risk Codes: | R23/24/25;R33; |
| Safety: | Poison by ingestion, skin contact, and intravenous routes. A skin and eye irritant. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. |
| PSA: | 23.24000 |
| LogP: | -0.76780 |
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| Conditions | Yield |
|---|---|
| With (Cs2O)5.5-(P2O5)1.8/SiO2 at 420℃; Temperature; |
| Conditions | Yield |
|---|---|
| In toluene Et2Zn and 1-aziridineethanol (1 equiv.) were reacted in toluene; | 99% |
- 1072-52-2
2-(1-aziridine)ethanol
| Conditions | Yield |
|---|---|
| With di-isopropyl azodicarboxylate; triphenylphosphine In dichloromethane at 0 - 20℃; Mitsunobu Displacement; | 99% |
- 1072-52-2
2-(1-aziridine)ethanol
- 680199-30-8
2-chloro-3,5-dinitro-N-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]benzamide
- 944088-69-1
2-[(2-chloroethyl)(2-hydroxyethyl)amino]-3,5-dinitro-N-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]benzamide
| Conditions | Yield |
|---|---|
| With lithium chloride In various solvent(s) cooling; | 97% |
| In 3-methyl-butan-2-one at 5 - 20℃; Product distribution / selectivity; | 97% |
- 1072-52-2
2-(1-aziridine)ethanol
- 1214883-04-1
trans-(bis[(acetato-κO)-(2-(1-aziridinyl)ethanol-κ2-N,O)])cobalt(II)
| Conditions | Yield |
|---|---|
| In dichloromethane (Ar); Schlenk techniques; 2-(1-azirinyl)ethanol added to CH2Cl2 soln. ofCo(OAc)2; stirred at 21°C for 18 h; evapn.; dried in vac.; elem. anal.; | 96% |
| Conditions | Yield |
|---|---|
| In dichloromethane (Ar); Schlenk techniques; 2-(1-azirinyl)ethanol added to CH2Cl2 soln. ofCoCl2; stirred at 21°C for 18 h; evapn.; dried in vac.; stirred in dry acetone; decanted; dried in vac.; elem. anal.; | 95% |
- 1072-52-2
2-(1-aziridine)ethanol
- 88303-65-5
<2-<(2-hydroxyethyl)amino>ethyl>hydrazine
| Conditions | Yield |
|---|---|
| With hydrazine In water at 113℃; for 44h; | 94% |
| With hydrazine hydrate In water for 48h; Heating; | 60% |
- 1072-52-2
2-(1-aziridine)ethanol
- 7789-45-9
copper(ll) bromide
- 1313430-51-1
tetrakis(μ3-(2-aziridin-1-ylethanolato-κ2N,O)bromidocopper(II))
| Conditions | Yield |
|---|---|
| In dichloromethane byproducts: HBr; (Ar); addn. of 1.2 equiv. of aziridine deriv. to suspn. of copper compd.in CH2Cl2, stirring for 18 h at room temp.; evapn., stirring in acetone overnight at room temp., decantation, dryingvac., elem. anal.; | 93% |
| Conditions | Yield |
|---|---|
| With lithium chloride In tetrahydrofuran cooling; | 92% |
| In tetrahydrofuran at 5 - 20℃; | 92% |
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Chemistry
Chemical Name: 1-Aziridineethanol
IUPAC NAME: 2-(Aziridin-1-yl)ethanol
CAS No.: 1072-52-2
EINECS: 87.12
RTECS: CM7000000
Molecular Formula: C4H9NO
Molecular Weight: 87.12 g/mol
Density: 1.097 g/cm3
Flash Point: 67.2 °C
Boiling Point: 168 °C at 760 mmHg
Following is the structure of 1-Aziridine ethanol (CAS No.1072-52-2):
Product Categories about 1-Aziridine ethanol (CAS No.1072-52-2) are Aziridines ; Simple 3-Membered Ring Compounds
The chemical synonymous of 1-Aziridine ethanol (CAS No.1072-52-2) are 2-(Aziridinyl)Ethanol ; 1-(2-Hydroxyethyl)Ethyleneimine ; 1-(2-Hydroxyethyl)Ethylenimine ; 1-Aziridneethanol ; 1-Aziridineethanol ; Hea ; N-[2-Hydroxyethyl]Aziridine ; N-(2-Hydroxyethyl)Ethyleneimine
Toxicity Data With Reference
| 1. | skn-rbt 545 mg open MOD | UCDS** Union Carbide Data Sheet. (Industrial Medicine and Toxicology Dept., Union Carbide Corp., 270 Park Ave., New York, NY 10017) 11/17/64 . | ||
| 2. | eye-rbt 1090 mg SEV | UCDS** Union Carbide Data Sheet. (Industrial Medicine and Toxicology Dept., Union Carbide Corp., 270 Park Ave., New York, NY 10017) 11/17/64 . | ||
| 3. | mmo-sat 1 µg/plate | ENMUDM Environmental Mutagenesis. 5 (Suppl 1)(1983),3. | ||
| 4. | sln-oin-dmg-orl 50 ppm | ENMUDM Environmental Mutagenesis. 7 (1985),325. | ||
| 5. | orl-rat LD50:74 mg/kg | JIHTAB Journal of Industrial Hygiene and Toxicology. 31 (1949),60. | ||
| 6. | ivn-mus LD50:56 mg/kg | CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) NX#03613 . | ||
| 7. | skn-rbt LD50:71 µL/kg | UCDS** Union Carbide Data Sheet. (Industrial Medicine and Toxicology Dept., Union Carbide Corp., 270 Park Ave., New York, NY 10017) 11/17/64 . |
Consensus Reports
IARC Cancer Review: Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 (1987),p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 9 (1975),p. 47.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . Reported in EPA TSCA Inventory.
Safety Profile
Poison by ingestion, skin contact, and intravenous routes. A skin and eye irritant. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes: 
T
Risk Statements about 1-Aziridine ethanol (CAS No.1072-52-2):
R34:Causes burns.
Safety Statements about 1-Aziridine ethanol (CAS No.1072-52-2):
S23:Do not breathe vapour.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.