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1-Aziridine ethanol
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Name

1-Aziridine ethanol

 EINECS N/A
CAS No. 1072-52-2 Density 1,088 g/cm3
PSA 23.24000 LogP -0.76780
Solubility N/A Melting Point N/A
Formula C4H9 N O Boiling Point 167-168°C
Molecular Weight 87.1216 Flash Point 67°C
Transport Information N/A Appearance CLEAR COLOURLESS LIQUID
Safety Poison by ingestion, skin contact, and intravenous routes. A skin and eye irritant. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. Risk Codes R23/24/25;R33;
Molecular Structure Molecular Structure of 1072-52-2 (1-Aziridineethanol) Hazard Symbols Irritant to skin and eyes.
Synonyms

1-(2-Hydroxyethyl)ethylenimine;1-(2-Hydroxylethyl)aziridine; 2-(Aziridin-1-yl)ethanol;N-(2-Hydroxyethyl)aziridine; N-(2-Hydroxyethyl)ethylenimine; N-(b-Hydroxyethyl)aziridine; NSC50209

Article Data 4

1-Aziridine ethanol Synthetic route

75-21-8

oxirane

151-56-4

ethyleneimine

1072-52-2

2-(1-aziridine)ethanol

141-43-5

ethanolamine

A

151-56-4

ethyleneimine

B

1072-52-2

2-(1-aziridine)ethanol

C

290-37-9

1,4-pyrazine

Conditions
ConditionsYield
With (Cs2O)5.5-(P2O5)1.8/SiO2 at 420℃; Temperature;
1072-52-2

2-(1-aziridine)ethanol

557-20-0

diethylzinc

C2H5(1-)*Zn(2+)*C2H4NC2H4O(1-)=[(C2H5)Zn(C2H4NC2H4O)]

Conditions
ConditionsYield
In toluene Et2Zn and 1-aziridineethanol (1 equiv.) were reacted in toluene;99%
1072-52-2

2-(1-aziridine)ethanol

methyl (E)-5-[4-(2,2-dimethylpropanoyloxy)phenyl]-5-(4-hydroxyphenyl)-4-phenyl-pent-4-enoate

(E)-methyl 5-(4-(2-(aziridin-1-yl)ethoxy)phenyl)-4-phenyl-5-(4-(pivaloyloxy)phenyl)pent-4-enoate

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In dichloromethane at 0 - 20℃; Mitsunobu Displacement;99%
1072-52-2

2-(1-aziridine)ethanol

680199-30-8

2-chloro-3,5-dinitro-N-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]benzamide

944088-69-1

2-[(2-chloroethyl)(2-hydroxyethyl)amino]-3,5-dinitro-N-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]benzamide

Conditions
ConditionsYield
With lithium chloride In various solvent(s) cooling;97%
In 3-methyl-butan-2-one at 5 - 20℃; Product distribution / selectivity;97%
1072-52-2

2-(1-aziridine)ethanol

71-48-7, 917-69-1, 5931-89-5, 55881-15-7, 68931-68-0, 68931-69-1, 93029-27-7

cobalt(II) acetate

1214883-04-1

trans-(bis[(acetato-κO)-(2-(1-aziridinyl)ethanol-κ2-N,O)])cobalt(II)

Conditions
ConditionsYield
In dichloromethane (Ar); Schlenk techniques; 2-(1-azirinyl)ethanol added to CH2Cl2 soln. ofCo(OAc)2; stirred at 21°C for 18 h; evapn.; dried in vac.; elem. anal.;96%
1072-52-2

2-(1-aziridine)ethanol

7646-79-9

cobalt(II) chloride

cis-(bis[chlorido-(2-(1-aziridinyl)ethanol-κ2-N,O)])cobalt(II)

Conditions
ConditionsYield
In dichloromethane (Ar); Schlenk techniques; 2-(1-azirinyl)ethanol added to CH2Cl2 soln. ofCoCl2; stirred at 21°C for 18 h; evapn.; dried in vac.; stirred in dry acetone; decanted; dried in vac.; elem. anal.;95%
1072-52-2

2-(1-aziridine)ethanol

88303-65-5

<2-<(2-hydroxyethyl)amino>ethyl>hydrazine

Conditions
ConditionsYield
With hydrazine In water at 113℃; for 44h;94%
With hydrazine hydrate In water for 48h; Heating;60%
1072-52-2

2-(1-aziridine)ethanol

7789-45-9

copper(ll) bromide

1313430-51-1

tetrakis(μ3-(2-aziridin-1-ylethanolato-κ2N,O)bromidocopper(II))

Conditions
ConditionsYield
In dichloromethane byproducts: HBr; (Ar); addn. of 1.2 equiv. of aziridine deriv. to suspn. of copper compd.in CH2Cl2, stirring for 18 h at room temp.; evapn., stirring in acetone overnight at room temp., decantation, dryingvac., elem. anal.;93%
1072-52-2

2-(1-aziridine)ethanol

6266-51-9

2-chloro-3,5-dinitrobenzamide

2-[(2-chloroethyl)(2-hydroxyethyl)amino]-3,5-dinitrobenzamide

Conditions
ConditionsYield
With lithium chloride In tetrahydrofuran cooling;92%
In tetrahydrofuran at 5 - 20℃;92%

1-Aziridine ethanol Chemical Properties

Chemical Name: 1-Aziridineethanol
IUPAC NAME: 2-(Aziridin-1-yl)ethanol
CAS No.: 1072-52-2
EINECS: 87.12
RTECS: CM7000000
Molecular Formula: C4H9NO
Molecular Weight: 87.12 g/mol
Density: 1.097 g/cm3
Flash Point: 67.2 °C
Boiling Point: 168 °C at 760 mmHg
Following is the structure of 1-Aziridine ethanol (CAS No.1072-52-2):


Product Categories about 1-Aziridine ethanol (CAS No.1072-52-2) are Aziridines ; Simple 3-Membered Ring Compounds
The chemical synonymous of 1-Aziridine ethanol (CAS No.1072-52-2) are 2-(Aziridinyl)Ethanol ; 1-(2-Hydroxyethyl)Ethyleneimine ; 1-(2-Hydroxyethyl)Ethylenimine ; 1-Aziridneethanol ; 1-Aziridineethanol ; Hea ; N-[2-Hydroxyethyl]Aziridine ; N-(2-Hydroxyethyl)Ethyleneimine

1-Aziridine ethanol Toxicity Data With Reference

1.    

skn-rbt 545 mg open MOD

     UCDS**    Union Carbide Data Sheet. (Industrial Medicine and Toxicology Dept., Union Carbide Corp., 270 Park Ave., New York, NY 10017) 11/17/64 .
2.    

eye-rbt 1090 mg SEV

     UCDS**    Union Carbide Data Sheet. (Industrial Medicine and Toxicology Dept., Union Carbide Corp., 270 Park Ave., New York, NY 10017) 11/17/64 .
3.    

mmo-sat 1 µg/plate

     ENMUDM    Environmental Mutagenesis. 5 (Suppl 1)(1983),3.
4.    

sln-oin-dmg-orl 50 ppm

     ENMUDM    Environmental Mutagenesis. 7 (1985),325.
5.    

orl-rat LD50:74 mg/kg

     JIHTAB    Journal of Industrial Hygiene and Toxicology. 31 (1949),60.
6.    

ivn-mus LD50:56 mg/kg

     CSLNX*    U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) NX#03613 .
7.    

skn-rbt LD50:71 µL/kg

     UCDS**    Union Carbide Data Sheet. (Industrial Medicine and Toxicology Dept., Union Carbide Corp., 270 Park Ave., New York, NY 10017) 11/17/64 .

1-Aziridine ethanol Consensus Reports

IARC Cancer Review: Group 3 IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 (1987),p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Limited Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 9 (1975),p. 47.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . Reported in EPA TSCA Inventory.

1-Aziridine ethanol Safety Profile

Poison by ingestion, skin contact, and intravenous routes. A skin and eye irritant. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes: ToxicT
Risk Statements about 1-Aziridine ethanol (CAS No.1072-52-2):
R34:Causes burns.
Safety Statements about 1-Aziridine ethanol (CAS No.1072-52-2):
S23:Do not breathe vapour. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.

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