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| CAS No.: | 614-80-2 |
|---|---|
| Name: | 2-Acetamidophenol |
| Molecular Structure: | |
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|
|
| Formula: | C8H9NO2 |
| Molecular Weight: | 151.165 |
| Synonyms: | o-Acetamidophenol;o-(Acetylamino)phenol;2-(Acetylamino)phenol;2-Acetaminophenol;o-Hydroxyacetanilide;Acet-o-aminofenol;N-Acetyl-o-aminophenol;N-Acetyl-2-aminophenol;Acetanilide, 2-hydroxy-;Phenol, 2-acetamido-;N-(2-hydroxyphenyl)acetamide;2'-hydroxyacetanilide;Acetamide, N- (2-hydroxyphenyl)-; |
| EINECS: | 210-396-9 |
| Density: | 1.249 g/cm3 |
| Melting Point: | 205-210 °C(lit.) |
| Boiling Point: | 343.1 °C at 760 mmHg |
| Flash Point: | 161.3 °C |
| Appearance: | light brown powder |
| Hazard Symbols: |
 Xn,  Xi
|
| Risk Codes: | 36/38-22-36/37/38 |
| Safety: | 26-36-37/39 |
| Transport Information: | UN 2811 |
| PSA: | 49.33000 |
| LogP: | 1.42360 |
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Chemistry
The chemical synonyms of are O-HYDROXYACETANILIDE;O-ACETAMIDOPHENOL;O-ACETAMINOPHENOL;N-(2-Hydroxyphenyl)acetamide;AKOS BBB/377;2-ACETYLAMINOPHENOL;2-ACETAMIDOPHENOL;2-ACETAMINO PHENOL .The molecular structure of 2′-HYDROXYACETANILIDE(614-80-2) is
.Uses
2′-HYDROXYACETANILIDE(614-80-2) can be used in organic synthesis, the pharmaceutical industry (anti-tumor drug pyrimidine intermediates of benzene mustard), also be used as a hydrogen peroxide stabilizer.
Production
O-amino phenol, acetic acid and acetic anhydride mix (untill the crystallization occurs), and then the mixture is heated directly on the fire untill all dissolved, stop heating.The mixture was cooling, washed with water,and filtered.The product is derived by recrystallized from ethano at 70 ~ 80 ℃ .
Toxicity Data With Reference
| 1. | eye-rbt 500 mg/24H MLD | 28ZPAK Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V.,Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha,Czechoslovakia.: 1972,106. | ||
| 2. | orl-rat LD50:4960 mg/kg | 28ZPAK Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V.,Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha,Czechoslovakia.: 1972,106. |
Consensus Reports
Safety Profile
Mildly toxic by ingestion. An eye irritant. When heated to decomposition it emits toxic fumes of NOx. Safety 26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
37/39: Wear suitable gloves and eye/face protection.Risk Codes is R22;R36/38.Hazard class is 6.1(b). Hazard Symbols: 
.