Related Products
- 1064-48-8Acid Black 1
- 106449-15-4Tanakine
- 106449-56-3Adenosine,2'-deoxy-2,3-dihydro-2-oxo-
- 106454-69-7N-Boc-D-Phenylalaninol
- 106-45-6p-Toluenethiol
- 106461-41-03H-1,2,4-Triazol-3-one,2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-2-(1-methylpropyl)-
- 106463-17-6Tamsulosin hydrochloride
- 1064662-40-3SNT-207707
- 106-46-71,4-Dichlorobenzene
- 1064684-44-1PSI 7851
Hot Products
- 104987-11-3Tacrolimus
- 141-53-7Sodium formate
- 8001-54-5Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
- 9003-39-8Povidone
- 10161-34-9Trenbolone acetate
- 402957-28-2Telaprevir
- 68-19-9Cyanocobalamin
- 7631-86-9Silicon dioxide
- 302-79-4Tretinoin
- 77-92-9Citric acid
|
Basic Information |
|
Post buying leads |
|
Suppliers |
|
Cas Database |
| Name |
2-Amino-4-(trifluoromethyl)pyridine |
EINECS | -0 |
| CAS No. | 106447-97-6 | Density | 1.368 g/cm3 |
| PSA | 38.91000 | LogP | 2.26380 |
| Solubility | N/A | Melting Point |
70-74 °C |
| Formula | C6H5F3N2 | Boiling Point | 221.338 °C at 760 mmHg |
| Molecular Weight | 162.114 | Flash Point | 87.662 °C |
| Transport Information | UN 2811 6.1/PG 3 | Appearance | N/A |
| Safety | 26-36/37-45-36/37/39 | Risk Codes | 25-36/37/38-43 |
| Molecular Structure |
|
Hazard Symbols |
 T, Xi, C
|
| Synonyms |
(4-Trifluoromethylpyridin-2-yl)amine;2-Amino-4-trifluoromethylpyridine;4-(Trifluoromethyl)pyridin-2-amine;2-Amino-4-(trifluoromethyl)pyridine; |
Article Data | 14 |
2-Amino-4-(trifluoromethyl)pyridine Synthetic route
- 81565-18-6
2-chloro-4-trifluoromethyl pyridine
- 106447-97-6
2-amino-4-(trifluoromethyl)pyridine
Conditions
| Conditions | Yield |
|---|---|
| With ammonia In water at 170℃; for 24h; | 76% |
| With ammonium hydroxide at 180℃; | |
| With ammonium hydroxide | |
| With ammonia |
- 39890-98-7
2,6-dichloro-4-(trifluoromethyl)pyridine
- 106447-97-6
2-amino-4-(trifluoromethyl)pyridine
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: 2,6-dichloro-4-(trifluoromethyl)pyridine With ammonia In tetrahydrofuran; water at 150℃; for 6h; autoclave; Stage #2: With hydrogen; 5%-palladium/activated carbon In tetrahydrofuran; water at 100℃; under 15001.5 Torr; for 3h; Product distribution / selectivity; | 71.9% |
- 917806-22-5
5-ethoxy-3-hydroxy-3-(trifluoromethyl)pent-4-enenitrile
- 106447-97-6
2-amino-4-(trifluoromethyl)pyridine
Conditions
| Conditions | Yield |
|---|---|
| With ammonia In water at 125℃; under 10501.1 Torr; for 24h; Autoclave; | 68% |
- 106447-97-6
2-amino-4-(trifluoromethyl)pyridine
Conditions
| Conditions | Yield |
|---|---|
| With acetamidine hydrochloride; sodium hydroxide In water; dimethyl sulfoxide at 130℃; for 24h; Schlenk technique; chemoselective reaction; | 61% |
- 944401-56-3
2-amino-5-bromo-4-(trifluoromethyl)pyridine
- 73183-34-3
bis(pinacol)diborane
A
- 944401-57-4
4-(trifluoromethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaboroloan-2-yl)pyridin-2-amine
B
- 106447-97-6
2-amino-4-(trifluoromethyl)pyridine
Conditions
| Conditions | Yield |
|---|---|
| With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate In 1,4-dioxane at 115℃; for 8h; Inert atmosphere; | A 48% B n/a |
| With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In 1,4-dioxane at 115℃; for 8h; | |
| With potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In 1,4-dioxane at 115℃; for 8.25h; Heating / reflux; | |
| With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate In 1,4-dioxane at 115℃; for 8h; Inert atmosphere; |
- 106447-97-6
2-amino-4-(trifluoromethyl)pyridine
Conditions
| Conditions | Yield |
|---|---|
| With hydrogenchloride Hydrolysis; |
- 22253-59-4
1-oxido-4-(trifluoromethyl)pyridin-1-ium
- 106447-97-6
2-amino-4-(trifluoromethyl)pyridine
Conditions
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: CH2Cl2 / Heating 2: conc. HCl View Scheme |
- 39890-98-7
2,6-dichloro-4-(trifluoromethyl)pyridine
A
- 130171-52-7
4-(trifluoromethyl)pyridine-2,6-diamine
B
- 106447-97-6
2-amino-4-(trifluoromethyl)pyridine
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: 2,6-dichloro-4-(trifluoromethyl)pyridine With ammonia In water at 150℃; for 15h; autoclave; Stage #2: With hydrogen; 5%-palladium/activated carbon In water at 100℃; under 13501.4 Torr; for 3h; |
- 106447-97-6
2-amino-4-(trifluoromethyl)pyridine
- 1281872-45-4
2-amino-4-trifluoromethylpyridine hydrochloride
Conditions
| Conditions | Yield |
|---|---|
| With hydrogenchloride In toluene at 10 - 20℃; | 96.6% |
- 106447-97-6
2-amino-4-(trifluoromethyl)pyridine
- 944401-56-3
2-amino-5-bromo-4-(trifluoromethyl)pyridine
Conditions
| Conditions | Yield |
|---|---|
| With N-Bromosuccinimide In dichloromethane at 25℃; for 2h; Darkness; | 94% |
| With N-Bromosuccinimide In tetrahydrofuran at 0 - 20℃; for 1h; Concentration; | 91% |
| With N-Bromosuccinimide In dichloromethane at 20℃; Darkness; | 87.96% |
2-Amino-4-(trifluoromethyl)pyridine Chemical Properties
Molecular Formula: C6H5F3N2
Molar mass:162.11251 g/mol
Structure of 2-Amino-4-(trifluoromethyl)pyridine(106447-97-6):
Synonyms of 2-Amino-4-(trifluoromethyl)pyridine(106447-97-6):4-(TRIFLUOROMETHYL)PYRIDIN-2-AMINE;4-Trifluoromethyl-pyridin-2-ylamine;4-Trifluoromethyl-2-pyridinamine
Melting point:70-74 °C
Density:1.368 g/cm3
Flash Point:87.7 °C
Boiling Point:221.3 °C at 760 mmHg
Index of Refraction: 1.478
Vapour Pressure: 0.108 mmHg at 25°C
Molar mass:162.11251 g/mol
Structure of 2-Amino-4-(trifluoromethyl)pyridine(106447-97-6):
Synonyms of 2-Amino-4-(trifluoromethyl)pyridine(106447-97-6):4-(TRIFLUOROMETHYL)PYRIDIN-2-AMINE;4-Trifluoromethyl-pyridin-2-ylamine;4-Trifluoromethyl-2-pyridinamine
Melting point:70-74 °C
Density:1.368 g/cm3
Flash Point:87.7 °C
Boiling Point:221.3 °C at 760 mmHg
Index of Refraction: 1.478
Vapour Pressure: 0.108 mmHg at 25°C
2-Amino-4-(trifluoromethyl)pyridine Safety Profile
Hazard Codes:T
,Xi
,C
Risk Statements:
22: Harmful if swallowed
25: Toxic if swallowed
34: Causes burns
36: Irritating to the eyes
37: Irritating to the respiratory system
38: Irritating to the skin
43: May cause sensitization by skin contact
Safety Statements:
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
37: Wear suitable gloves
39: Wear eye/face protection
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
,Xi,CRisk Statements:
22: Harmful if swallowed
25: Toxic if swallowed
34: Causes burns
36: Irritating to the eyes
37: Irritating to the respiratory system
38: Irritating to the skin
43: May cause sensitization by skin contact
Safety Statements:
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
37: Wear suitable gloves
39: Wear eye/face protection
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
2-Amino-4-(trifluoromethyl)pyridine Specification
Product Categories of 2-Amino-4-(trifluoromethyl)pyridine(106447-97-6):pharmacetical;Amines;Pyridine series;Pyridines;Halogenated Heterocycles;Heterocyclic Building Blocks
Post a RFQ
1
What can I do for you?
Get Best Price
Get Best Price for 106447-97-6
2-Amino-4-(trifluoromethyl)pyridine
