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Cas Database |
| Name |
2-Bromo-5-cyanopyridine |
EINECS | -0 |
| CAS No. | 139585-70-9 | Density | 1.72 g/cm3 |
| PSA | 36.68000 | LogP | 1.71578 |
| Solubility | N/A | Melting Point |
136-140 °C(lit.) |
| Formula | C6H3BrN2 | Boiling Point | 261.642 °C at 760 mmHg |
| Molecular Weight | 183.007 | Flash Point | 112.037 °C |
| Transport Information | N/A | Appearance | N/A |
| Safety | 26-36/37/39 | Risk Codes | 36/37/38 |
| Molecular Structure |
|
Hazard Symbols |
 Xi
|
| Synonyms |
6-Bromonicotinonitrile;6-bromopyridine-3-carbonitrile; |
Article Data | 5 |
2-Bromo-5-cyanopyridine Synthetic route
- 33252-28-7
6-chloronicotinonitrile
- 139585-70-9
2-bromo-5-cyanopyridine
| Conditions | Yield |
|---|---|
| With phosphorus tribromide at 145℃; for 64h; | 81% |
| Stage #1: 6-chloronicotinonitrile With phosphorus tribromide at 145℃; for 64h; Stage #2: With sodium hydrogencarbonate In water | 81% |
| With phosphorus tribromide at 145℃; for 64h; | 61% |
- 557-21-1
zinc(II) cyanide
- 223463-14-7
6-bromopyridin-3-ylboronic acid
- 139585-70-9
2-bromo-5-cyanopyridine
| Conditions | Yield |
|---|---|
| With copper(II) nitrate trihydrate; cesium fluoride In methanol; water at 80℃; for 2h; | 61% |
- 149806-06-4
6-bromonicotinaldehyde
- 139585-70-9
2-bromo-5-cyanopyridine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: hydroxylamine hydrochloride; potassium carbonate / 20 °C 2: potassium carbonate; fluorosulfonyl fluoride / 12 h / 20 °C View Scheme |
- 864266-28-4
C6H5BrN2O
- 139585-70-9
2-bromo-5-cyanopyridine
| Conditions | Yield |
|---|---|
| With fluorosulfonyl fluoride; potassium carbonate at 20℃; for 12h; | 340 mg |
- 122306-01-8
2-bromo-5-(hydroxymethyl)pyridine
- 139585-70-9
2-bromo-5-cyanopyridine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: potassium carbonate; fluorosulfonyl fluoride; dimethyl sulfoxide / 20 °C 2: hydroxylamine hydrochloride; potassium carbonate / 20 °C 3: potassium carbonate; fluorosulfonyl fluoride / 12 h / 20 °C View Scheme |
- 139585-70-9
2-bromo-5-cyanopyridine
- 16173-99-2
6-ethenylpyridine-3-carbonitrile
| Conditions | Yield |
|---|---|
| With triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In methanol at 20 - 80℃; for 8h; Product distribution / selectivity; Sealed tube; | 99% |
| With triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In methanol at 80℃; for 8h; Sealed tube; | 99% |
| With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; triethylamine In ethanol; water at 90℃; Suzuki Coupling; | 98% |
- 616-47-7
1-methyl-1H-imidazole
- 139585-70-9
2-bromo-5-cyanopyridine
| Conditions | Yield |
|---|---|
| In neat (no solvent) at 190℃; for 18h; Sealed tube; | 98% |
| at 190℃; for 18h; | 73% |
| at 20 - 190℃; for 18h; Inert atmosphere; | 70% |
| In neat (no solvent) at 190℃; for 18h; Sealed tube; |
- 139585-70-9
2-bromo-5-cyanopyridine
| Conditions | Yield |
|---|---|
| With tetrakis(triphenylphosphine) palladium(0); tri-tert-butyl phosphine; potassium carbonate In toluene at 100℃; Inert atmosphere; | 98% |
- 867-44-7
S-Methylisothiourea sulfate
- 139585-70-9
2-bromo-5-cyanopyridine
- 408350-80-1
6-(methylthio)nicotinonitrile
| Conditions | Yield |
|---|---|
| With caesium carbonate In dimethyl sulfoxide at 80℃; for 1h; | 98% |
- 139585-70-9
2-bromo-5-cyanopyridine
- 1400580-92-8
6-bromo-4-(((3S,4S)-1-(5-cyanopyridin-2-yl)-4-methylpyrrolidin-3-yl)amino)pyrrolo[1,2-b]pyridazine-3-carboxamide
| Conditions | Yield |
|---|---|
| With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 1.5h; Sealed tube; | 97% |
2-Bromo-5-cyanopyridine Chemical Properties
Molecular Formula: C6H3BrN2
Molecular Weight: 183.01 g/mol
Index of Refraction: 1.611
Density: 1.72 g/cm3
Flash Point: 112 °C
Enthalpy of Vaporization: 49.94 kJ/mol
Boiling Point: 261.6 °C at 760 mmHg
Vapour Pressure: 0.0114 mmHg at 25°C
Melting point: 136-140 °C(lit.)
Structure of 2-Bromo-5-cyanopyridine (CAS NO.139585-70-9):
IUPAC Name: 6-Bromopyridine-3-carbonitrile
Product Category of 2-Bromo-5-cyanopyridine (CAS NO.139585-70-9): Bromides;Carboxes;Boron, Nitrile, Thio,& TM-Cpds;Heterocycles;Pyridine series;Halides
2-Bromo-5-cyanopyridine Uses
2-Bromo-5-cyanopyridine (CAS NO.139585-70-9) is used as pharmaceutical intermediate.
2-Bromo-5-cyanopyridine Safety Profile
Hazard Codes: 
Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
2-Bromo-5-cyanopyridine Specification
2-Bromo-5-cyanopyridine , its cas register number is 139585-70-9. It also can be called 3-pyridinecarbonitrile, 6-bromo- ; 6-Bromopyridine-3-carbonitrile ; and 6-Bromonicotinonitrile .
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