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Cas Database |
| Name |
2-Chloro-5-chloromethylpyridine |
EINECS | -0 |
| CAS No. | 70258-18-3 | Density | 1.324 g/cm3 |
| PSA | 12.89000 | LogP | 2.47380 |
| Solubility | Insoluble in water. | Melting Point |
37-42 °C(lit.) |
| Formula | C6H5Cl2N | Boiling Point | 249.8 °C at 760 mmHg |
| Molecular Weight | 162.018 | Flash Point | 129 °C |
| Transport Information | UN 3261 8/PG 2 | Appearance | beige moist crystals |
| Safety | 26-36/37/39-45-25-36-16 | Risk Codes | 22-34-36-10 |
| Molecular Structure |
|
Hazard Symbols |
 C,  Xi,  F
|
| Synonyms |
2-Chloro-5-(chloromethyl)pyridine;Pyridine, 2-chloro-5-(chloromethyl)-; |
Article Data | 36 |
2-Chloro-5-chloromethylpyridine Synthetic route
- 150807-86-6
2,-chloro-2-(chloromethyl)-4-cyanobutyraldehyde
- 70258-18-3
2-chloro-5-(chloromethyl)pyridine
| Conditions | Yield |
|---|---|
| With phosgene In toluene at 50℃; for 6h; Temperature; | 97% |
| In chlorobenzene at 105 - 110℃; for 0.283333h; Temperature; | 79.5% |
- 109205-68-7
5-(hydroxymethyl)pyridin-2-ol
- 70258-18-3
2-chloro-5-(chloromethyl)pyridine
| Conditions | Yield |
|---|---|
| With phosphorus pentachloride In chloroform; water; trichlorophosphate | 95% |
- 18368-64-4
2-chloro-5-methylpyridine
- 70258-18-3
2-chloro-5-(chloromethyl)pyridine
| Conditions | Yield |
|---|---|
| With chlorine at 115 - 120℃; for 5.5h; Temperature; | 93.5% |
| With chlorine at 120℃; under 3750.38 Torr; Temperature; Pressure; Green chemistry; | 93.2% |
| With 2,2'-azobis(isobutyronitrile); chlorine In dichloromethane at 120℃; under 7500.75 - 15001.5 Torr; for 1h; | 70% |
- 70258-18-3
2-chloro-5-(chloromethyl)pyridine
| Conditions | Yield |
|---|---|
| With phosgene In N,N-dimethyl-formamide; toluene at 20 - 30℃; for 4h; Temperature; | 91.2% |
- 69045-78-9
2-chloro-5-(Trichloromethyl)-pyridine
- 70258-18-3
2-chloro-5-(chloromethyl)pyridine
| Conditions | Yield |
|---|---|
| With ammonium hydroxide; 5%-palladium/activated carbon; hydrogen In acetic acid methyl ester; water at 55 - 60℃; under 6000.6 Torr; for 7h; Reagent/catalyst; Pressure; Solvent; Temperature; Autoclave; | 88.6% |
- 108-77-0
1,3,5-trichloro-2,4,6-triazine
- 150807-86-6
2,-chloro-2-(chloromethyl)-4-cyanobutyraldehyde
- 70258-18-3
2-chloro-5-(chloromethyl)pyridine
| Conditions | Yield |
|---|---|
| With N,N-dimethyl-formamide In toluene at 90 - 100℃; for 2.5h; Concentration; Temperature; Solvent; Reagent/catalyst; | 85.8% |
- 594-19-4
tert.-butyl lithium
- 444120-94-9
2-chloro-5-(4,4, 5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
A
- 70258-18-3
2-chloro-5-(chloromethyl)pyridine
C
- 1693-83-0
1-Methyl-4-((R)-2-methyl-propane-2-sulfinyl)-benzene
| Conditions | Yield |
|---|---|
| With zinc(II) chloride In tetrahydrofuran; toluene; pentane at -78 - 20℃; for 22h; Inert atmosphere; | A 25% B 8% C 69% |
- 108-99-6
3-Methylpyridine
- 70258-18-3
2-chloro-5-(chloromethyl)pyridine
| Conditions | Yield |
|---|---|
| With chlorine at 250 - 282℃; for 0.25h; Reagent/catalyst; Inert atmosphere; | 51% |
| Multi-step reaction with 3 steps 1: sodium amide / ethanol / 2.17 h / 66 °C / Reflux 2: methyl nitrite; hydrogenchloride / methanol / 5 h / 10 - 12 °C 3: methyl nitrite; hydrogenchloride / methanol / 5 h / 10 - 12 °C View Scheme |
- 21543-49-7
2-Chloro-5-hydroxymethylpyridine
- 70258-18-3
2-chloro-5-(chloromethyl)pyridine
| Conditions | Yield |
|---|---|
| With thionyl chloride In dichloromethane for 3h; | |
| With thionyl chloride In chloroform | |
| With pyridine; thionyl chloride |
- 73781-91-6
6-Chloronicotinic acid methyl ester
- 70258-18-3
2-chloro-5-(chloromethyl)pyridine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: DIBAL-H / tetrahydrofuran; hexane / 1 h / 0 °C 2: SOCl2 / CH2Cl2 / 3 h View Scheme | |
| Multi-step reaction with 2 steps 1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C 2: thionyl chloride / dichloromethane / 2 h View Scheme | |
| Multi-step reaction with 2 steps 1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere 2: thionyl chloride / dichloromethane / 2 h / Inert atmosphere View Scheme |
2-Chloro-5-chloromethylpyridine Chemical Properties
Molecular structure of 2-Chloro-5-chloromethylpyridine (CAS NO.70258-18-3) is:
Product Name: 2-Chloro-5-chloromethylpyridine
CAS Registry Number: 70258-18-3
IUPAC Name: 2-Chloro-5-(chloromethyl)pyridine
Molecular Weight: 162.0166 [g/mol]
Molecular Formula: C6H5Cl2N
XLogP3-AA: 2.2
H-Bond Donor: 0
H-Bond Acceptor: 1
Melting Point: 37-42 °C(lit.)
Surface Tension: 42.6 dyne/cm
Density: 1.324 g/cm3
Flash Point: 129 °C
Enthalpy of Vaporization: 46.73 kJ/mol
Boiling Point: 249.8 °C at 760 mmHg
Vapour Pressure: 0.0356 mmHg at 25°C
Product Categories: Halometyl; Pyridine; Pyridine series; Methyl Halides; Pyridines; Chloropyridines; Halopyridines; Methyl Halides; C6Heterocyclic Building Blocks; Halogenated Heterocycles; Heterocyclic Building Blocks
2-Chloro-5-chloromethylpyridine Uses
2-Chloro-5-chloromethylpyridine (CAS NO.70258-18-3) is the intermediates of the pesticide Imidacloprid and Acetamiprid.
2-Chloro-5-chloromethylpyridine Safety Profile
Safty information about 2-Chloro-5-chloromethylpyridine (CAS NO.70258-18-3) is:
Hazard Codes: 
C,
Xi,
F
Risk Statements: 22-34-36-10
R22:Harmful if swallowed.
R34:Causes burns.
R36:Irritating to eyes.
R10:Flammable.
Safety Statements: 26-36/37/39-45-25-36-16
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S25:Avoid contact with eyes.
S36:Wear suitable protective clothing.
S16:Keep away from sources of ignition.
RIDADR: UN 3261 8/PG 2
WGK Germany: 3
Hazard Note: Corrosive/Harmful
HazardClass: LACHRYMATOR, CORROSIVE
PackingGroup: II
2-Chloro-5-chloromethylpyridine Specification
2-Chloro-5-chloromethylpyridine , its cas register number is 70258-18-3. It also can be called 2-Chloro-5-(chloromethyl)pyridine ; Pyridine, 2-chloro-5-(chloromethyl)- .It is a beige moist crystals.
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