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2-Hydroxyethylhydrazine

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Name

2-Hydroxyethylhydrazine

EINECS 203-711-6
CAS No. 109-84-2 Density 1.063 g/cm3
PSA 58.28000 LogP -0.46680
Solubility Soluble in water, alcohols and glycols. Melting Point -70 °C(lit.)
Formula C2H8N2O Boiling Point 248.9 °C at 760 mmHg
Molecular Weight 76.0983 Flash Point 73.9 °C
Transport Information UN 2810 6.1/PG 3 Appearance Clear colorless oily liquid
Safety 23-26-36/37/39-45 Risk Codes 23/24/25-36/37/38-40
Molecular Structure Molecular Structure of 109-84-2 (2-Hydroxyethylhydrazine) Hazard Symbols ToxicT
Synonyms

Ethanol,2-hydrazino- (6CI,7CI,8CI,9CI);(2-Hydroxyethyl)hydrazine;(b-Hydroxyethyl)hydrazine;1-(2-Hydroxyethyl)hydrazine;2-Hydrazineethanol;2-Hydrazinoethanol;2-Hydrazinoethyl alcohol;2-hydrazinylethanol;BOH;Ethanolhydrazine;HEH;Hydrazineethanol;Hydroxyethylhydrazine;N-(2-Hydroxyethyl)hydrazine;NSC189820;

Article Data 16

2-Hydroxyethylhydrazine Consensus Reports

Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

2-Hydroxyethylhydrazine Specification

The 2-Hydrazinoethanol, with its CAS registry number 109-84-2, is a kind of clear colorless oily liquid. And as to its usage, it is usually applied as the inhibitor of phospholipid methylation in yeast.

The physical properties of this chemical are as below: (1)ACD/LogP: -1.68; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -3.56; (4)ACD/LogD (pH 7.4): -1.98; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1.45; (9)#H bond acceptors: 3; (10)#H bond donors: 4; (11)#Freely Rotating Bonds: 4; (12)Polar Surface Area: 15.71; (13)Index of Refraction: 1.47; (14)Molar Refractivity: 19.97 cm3; (15)Molar Volume: 71.5 cm3; (16)Polarizability: 7.92×10-24 cm3; (17)Surface Tension: 45.1 dyne/cm; (18)Density: 1.063 g/cm3; (19)Flash Point: 73.9 °C; (20)Enthalpy of Vaporization: 56.48 kJ/mol; (21)Boiling Point: 248.9 °C at 760 mmHg; (22)Vapour Pressure: 0.00381 mmHg at 25°C; (23)Exact Mass: 76.063663; (24)MonoIsotopic Mass: 76.063663; (25)Topological Polar Surface Area: 58.3; (26)Heavy Atom Count: 5; (27)Complexity: 17.1.

Use of this chemical: 2-Hydrazinoethanol could react with (E)-3-dimethylamino-2-formylpropenenitrile to produce 1-(2-hydroxy-ethyl)-1H-pyrazole-4-carbonitrile. This reaction happens in the presence of the reagent of conc. HCl and the solvent of ethanol. And it requires 30 min to react in the conditon of heating, with its yield of 64%.

When you are dealing with this chemical, you should be very careful. This is a kind of toxic chemical and may at low levels cause damage to health. This is irritating to eyes, respiratory system and skin and it will be very dangerous to our body if by inhalation, in contact with skin and if swallowed. Then it has limited evidence of a carcinogenic effect. Therefore, you should wear suitable protective clothing, gloves and eye/face protection. And if in case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Then do remember not to breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer).

In addition, you could convert the following datas into the molecular structure:
(1)Canonical SMILES: C(CO)NN
(2)InChI: InChI=1S/C2H8N2O/c3-4-1-2-5/h4-5H,1-3H2
(3)InChIKey: GBHCABUWWQUMAJ-UHFFFAOYSA-N 

Below are the toxicity information of this chemical:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LDLo skin 5mL/kg (5mL/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION National Technical Information Service. Vol. OTS0555935,
mouse LD50 oral 139mg/kg (139mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 2, Pg. 76, 1968.
rat LD50 intraperitoneal 100mg/kg (100mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA
National Technical Information Service. Vol. OTS0555935,

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