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Cas Database |
| Name |
2-Hydroxyimipramine |
EINECS | N/A |
| CAS No. | 303-70-8 | Density | 1.107g/cm3 |
| PSA | 26.71000 | LogP | 3.64560 |
| Solubility | N/A | Melting Point |
130-132°C |
| Formula | C19H24 N2 O | Boiling Point | 469°Cat760mmHg |
| Molecular Weight | 296.412 | Flash Point | 239.5°C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Poison by intravenous route. Moderately toxic by ingestion. Experimental teratogenic effects. When heated to decomposition it emits toxic fumes of NOx. | Risk Codes | N/A |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
2-Hydroxyimipramine;G 33679 |
Article Data | 2 |
2-Hydroxyimipramine Chemical Properties
Molecular structure of 2-Hydroxyimipramine (CAS NO.303-70-8) is:
Product Name: 2-Hydroxyimipramine
CAS Registry Number: 303-70-8
IUPAC Name: 11-[3-(dimethylamino)propyl]-5,6-dihydrobenzo[b][1]benzazepin-8-ol
Molecular Weight: 296.40666 [g/mol]
Molecular Formula: C19H24N2O
XLogP3: 4.4
H-Bond Donor: 1
H-Bond Acceptor: 3
Melting Point: 130-132°C
Surface Tension: 44.8 dyne/cm
Density: 1.107 g/cm3
Flash Point: 239.5 °C
Enthalpy of Vaporization: 75.92 kJ/mol
Boiling Point: 469 °C at 760 mmHg
Vapour Pressure: 2.03E-09 mmHg at 25°C
Product Categories: Various Metabolites and Impurities;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
Classification Code: Drug / Therapeutic Agent ;Reproductive Effect
2-Hydroxyimipramine Uses
2-Hydroxyimipramine (CAS NO.303-70-8) can be used as a metabolite of Imipramine.
2-Hydroxyimipramine Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intravenous | 29mg/kg (29mg/kg) | Medicina et Pharmacologia Experimentalis. Vol. 15, Pg. 187, 1966. | |
| mouse | LD50 | oral | 733mg/kg (733mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 1617, 1969. | |
| rabbit | LD50 | intravenous | 12500ug/kg (12.5mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 1617, 1969. | |
| rat | LD50 | intravenous | 19mg/kg (19mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 1617, 1969. | |
| rat | LD50 | oral | 2980mg/kg (2980mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 1617, 1969. |
2-Hydroxyimipramine Safety Profile
Poison by intravenous route. Moderately toxic by ingestion. Experimental teratogenic effects. When heated to decomposition it emits toxic fumes of NOx.
2-Hydroxyimipramine Specification
2-Hydroxyimipramine , its cas register number is 303-70-8. It also can be called 2-OH-IP ; 5-(3-(Dimethylamino)propyl)-10,11-dihydro-5H-dibenz(b,f)azepin-2-ol ; 5-(3-(Dimethylamino)propyl)-2-hydroxy-10,11-dihydro-5H-dibenz(b,f)azepine ; 5-21-04-00033 (Beilstein Handbook Reference) ; BRN 1547775 ; G 33679 ; GP 33679 ; Hydroxyimipramine ; 5H-Dibenz(b,f)azepin-2-ol, 10,11-dihydro-5-(3-(dimethylamino)propyl)- . It is a tan solid.
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