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3,4,5-Trimethoxytoluene

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Name

3,4,5-Trimethoxytoluene

EINECS 229-239-0
CAS No. 6443-69-2 Density 1.025 g/cm3
PSA 27.69000 LogP 2.02080
Solubility N/A Melting Point 24-26 °C(lit.)
Formula C10H14O3 Boiling Point 272 °C at 760 mmHg
Molecular Weight 182.219 Flash Point 74.4 °C
Transport Information N/A Appearance clear yellow liquid
Safety 23-24/25 Risk Codes N/A
Molecular Structure Molecular Structure of 6443-69-2 (3,4,5-Trimethoxytoluene) Hazard Symbols IrritantXi
Synonyms

1,2,3-Trimethoxy-5-methylbenzene;Trimethoxytoluene;

Article Data 54

3,4,5-Trimethoxytoluene Synthetic route

86-81-7

3,4,5-trimethoxy-benzaldehyde

6443-69-2

3,4,5-trimethoxytoluene

Conditions
ConditionsYield
Stage #1: 3,4,5-trimethoxy-benzaldehyde With hydrazine hydrate; potassium hydroxide In ethylene glycol at 70℃; for 2h; Wolff-Kishner Reduction;
Stage #2: In ethylene glycol at 150℃; for 2h;
100%
With hydrogenchloride; hydrogen; palladium on activated charcoal In methanol at 20℃; under 760.051 Torr; for 1.5h;98%
With hydrogen; palladium on activated charcoal In acetic acid under 30002.4 Torr; for 72h; Ambient temperature;97%
212573-50-7

(2,3,4-trimethoxy-6-methylphenyl)boronic acid

1432583-85-1

N,N-diethyl-6-iodo-3-isopropoxy-2-(trimethylsilyl)benzamide

6443-69-2

3,4,5-trimethoxytoluene

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In 1,2-dimethoxyethane; water Suzuki-Miyaura Coupling; Inert atmosphere; Reflux;100%
212573-50-7

(2,3,4-trimethoxy-6-methylphenyl)boronic acid

1432583-86-2

N,N-diethyl-2-iodo-5-isopropoxybenzamide

6443-69-2

3,4,5-trimethoxytoluene

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In 1,2-dimethoxyethane; water Suzuki-Miyaura Coupling; Inert atmosphere; Reflux;100%
4003-98-9

1-(2-hexyl)-2,5-dimethylbenzene

104-15-4

toluene-4-sulfonic acid

6443-69-2

3,4,5-trimethoxytoluene

Conditions
ConditionsYield
In water98.5%

p-toluenesulfonic acid

153754-60-0

5-(p-xylyl)-hexene

6443-69-2

3,4,5-trimethoxytoluene

Conditions
ConditionsYield
98%
86-81-7

3,4,5-trimethoxy-benzaldehyde

109-73-9

N-butylamine

A

935250-90-1

N-butyl-3,4,5-trimethoxybenzylamine hydrochloride

B

6443-69-2

3,4,5-trimethoxytoluene

Conditions
ConditionsYield
With chloroform; 10% Pd/C; hydrogen In methanol at 20℃; under 760.051 Torr; for 2h; chemoselective reaction;A 97%
B 4%
67-56-1

methanol

86-81-7

3,4,5-trimethoxy-benzaldehyde

A

6443-69-2

3,4,5-trimethoxytoluene

B

3840-31-1

(3,4,5-trimethoxyphenyl)methanol

C

75921-68-5

1,2,3-trimethoxy-5-(methoxymethyl)benzene

Conditions
ConditionsYield
With hydrogen; acetic acid; palladium on activated charcoal In methanol at 20℃; under 760.051 Torr; for 2h;A 7%
B 75%
C 13%
With hydrogen at 160℃; under 15001.5 Torr; for 4h; Autoclave; Green chemistry;A 34.9 %Chromat.
B 53 %Chromat.
C 12.1 %Chromat.
86-81-7

3,4,5-trimethoxy-benzaldehyde

67-63-0

isopropyl alcohol

A

3,4,5-trimethoxybenzyl isopropyl ether

B

6443-69-2

3,4,5-trimethoxytoluene

C

3840-31-1

(3,4,5-trimethoxyphenyl)methanol

Conditions
ConditionsYield
With hydrogenchloride; hydrogen; palladium on activated charcoal at 20℃; under 760.051 Torr; for 7h;A 6%
B 75%
C 16%
157843-82-8

3,4,5-Trimethoxybenzyl pivalate

A

6443-69-2

3,4,5-trimethoxytoluene

B

75-98-9

Trimethylacetic acid

Conditions
ConditionsYield
With N1,N1,N12,N12-tetramethyl-7,8-dihydro-6H-dipyrido[1,2-a:2,1'-c][1,4]diazepine-2,12-diamine In N,N-dimethyl-formamide for 24h; Inert atmosphere; Glovebox; UV-irradiation;A 11%
B 73%

N,N-Dimethyl-N-<(trimethylsilyl)methyl>-3,4,5-trimethoxybenzylammonium iodide

6443-69-2

3,4,5-trimethoxytoluene

Conditions
ConditionsYield
With cesium fluoride In N,N,N,N,N,N-hexamethylphosphoric triamide for 0.5h; Ambient temperature;71%

3,4,5-Trimethoxytoluene Chemical Properties

The Molecular formula of  3,4,5-Trimethoxytoluene(6443-69-2):  C10H14O3
The Molecular Weight of  3,4,5-Trimethoxytoluene(6443-69-2) : 182.22
Molecular Structure : 
EINECS: 229-239-0
Melting point:  24-26 °C(lit.)
Boiling point: 117-118 °C5 mm Hg(lit.)
Flash point:  166 °F
density : 1.082 g/mL at 25 °C(lit.)
refractive index : n20/D 1.523(lit.)

3,4,5-Trimethoxytoluene Uses

3,4,5-Trimethoxytoluene(6443-69-2) is used as intermediates of drugs and agricultural chemicals.It is the main intermediate of Coenzyme Q10.

3,4,5-Trimethoxytoluene Safety Profile

Hazard Codes  3,4,5-Trimethoxytoluene(6443-69-2):  Xi
Safety Statements 3,4,5-Trimethoxytoluene(6443-69-2):
23:  Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) 
24/25:  Avoid contact with skin and eyes 
WGK Germany : 3
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