3-Amino-5-Methylisoxazole supplier

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Cas Database

Name	3-Amino-5-Methylisoxazole	EINECS	214-013-6
CAS No.	1072-67-9	Density	1.167 g/cm³
PSA	52.05000	LogP	1.14640
Solubility	soluble in water	Melting Point	59-63 °C
Formula	C₄H₆N₂O	Boiling Point	235.9 °C at 760 mmHg
Molecular Weight	98.1044	Flash Point	96.5 °C
Transport Information	N/A	Appearance	slightly yellow flakes
Safety	22-24/25-47-37/39-26-16-26/37/39/47-36	Risk Codes	5-36/37/38-11-36/37/38/5-20/21/22
Molecular Structure		Hazard Symbols	F,Xi
Synonyms	Isoxazole,3-amino-5-methyl- (6CI,7CI,8CI);5-Methyl-1,2-oxazol-3-amine;5-Methyl-3-aminoisoxazole;5-Methyl-3-isoxazolamine;5-Methyl-3-isoxazolylamine;NSC 159134;3-amino-5-methylisooxzole;	Article Data	22

3-Amino-5-Methylisoxazole Synthetic route

: C11H13N3O2S

: 1072-67-9
5-methylisoxazol-3-ylamine

Conditions

Conditions	Yield
Stage #1: C11H13N3O2S With hydroxylamine hydrochloride; potassium carbonate In water at 85℃; for 2h; Stage #2: With hydrogenchloride In water for 1h;	80%

: 4368-06-3
3-hydroxybutanenitrile

: 1072-67-9
5-methylisoxazol-3-ylamine

Conditions

Conditions	Yield
Stage #1: 3-hydroxybutanenitrile With hydroxylamine hydrochloride; potassium carbonate In water at 20 - 60℃; for 3h; Stage #2: With iron(III) chloride In toluene Reagent/catalyst; Temperature; Reflux;	77%

: 91377-59-2
2-(5-methyl-1,2-oxazol-3-yl)-1H-isoindole-1,3(2H)-dione

: 1072-67-9
5-methylisoxazol-3-ylamine

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol for 3h; Heating;	75.1%

: 108790-08-5, 127461-31-8
C4H4N2O2S

: 1165952-91-9
cyclohexa-1,3-diene

A: 1072-67-9
5-methylisoxazol-3-ylamine

: exo-3-(5-methylisoxazol-3-yl)-2λ4-thia-3-azabicyclo[2.2.2]oct-5-ene 2 oxide

: (1RS,2SR,4SR)-(2-oxo-2λ4-thia-3-azabicyclo[2.2.2]oct-5-en-3-yl)phosphonic acid diphenyl ester

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 22h; hetero-Diels-Alder reaction;	A n/a B n/a C 64%

: 100143-11-1
(5-methyl-isoxazol-3-yl)-carbamic acid benzyl ester

: 1072-67-9
5-methylisoxazol-3-ylamine

Conditions

Conditions	Yield
With sodium hydroxide

: 92087-97-3
(5-methyl-isoxazol-3-yl)-carbamic acid ethyl ester

: 1072-67-9
5-methylisoxazol-3-ylamine

Conditions

Conditions	Yield
With sodium hydroxide

: 4786-20-3
but-2-enenitrile

: 1072-67-9
5-methylisoxazol-3-ylamine

Conditions

Conditions	Yield
(i) Br2, MeOH, (ii) aq. NaOH, NH2CONHOH; Multistep reaction;

: 106124-31-6
(Z)-4-(5-Methyl-isoxazol-3-ylamino)-pent-3-en-2-one

: 1072-67-9
5-methylisoxazol-3-ylamine

Conditions

Conditions	Yield
With sodium ethanolate In ethanol for 3h; Heating; Yield given;

: 723-46-6
sulfamethoxazole

A: 1072-67-9
5-methylisoxazol-3-ylamine

B: C10H10ClN3O3S

C: 4-amino-3-chloro-N-(5-methyl-isoxazol-3-yl)-benzenesulphonamide

Conditions

Conditions	Yield
With sodium hypochlorite; borate buffer at 25℃; pH=9; Kinetics; Further Variations:; pH-values; Reagents; Solvents;

: 723-46-6
sulfamethoxazole

A: 1072-67-9
5-methylisoxazol-3-ylamine

B: C10H13N3O4S

C: C10H13N3O5S

D: 29699-89-6
N-(5-methyl-isoxazol-3-yl)-4-nitro-benzenesulfonamide

Conditions

Conditions	Yield
With hydrogenchloride; water; sodium chloride; sodium hydroxide pH=9.5; Catalytic behavior; Mechanism; Kinetics; pH-value; Reagent/catalyst; Inert atmosphere;

3-Amino-5-Methylisoxazole Chemical Properties

Molecular Formula:C₄H₆N₂O
Molar mass:98.10324g/mol
Structure of 3-Amino-5-methylisoxazole(1072-67-9):

Synonyms of 3-Amino-5-methylisoxazole(1072-67-9):3-Isoxazolamine, 5-methyl-;Isoxazole, 3-amino-5-methyl-;5-Methyl-3-aminoisoxazole;3-Methyl-5-aminoisoxazole;5-methylisoxazol-3-amine;5-Methyl-3-isoxazolamine
Density:1.167 g/cm³
Flash Point:96.5 °C
Boiling Point:235.9 °C at 760 mmHg
Index of Refraction:1.524
Vapour Pressure:0.0487 mmHg at 25°C
Melting point:59-63°C
Solubility:Soluble in alcohol, ether, vapor volatile with water
Water solubility:soluble
Appearance:White crystals
storage temp:Refrigerator

3-Amino-5-Methylisoxazole Uses

3-Amino-5-methylisoxazole(1072-67-9) is pharmaceutical intermediates,and can be used for the production of sulfonamide.

3-Amino-5-Methylisoxazole Production

3-Amino-5-methylisoxazole(1072-67-9) can be derived from the degradation of 5 - methylisoxazole -3 - carboxamide.

3-Amino-5-Methylisoxazole Toxicity Data With Reference

1.Oral, mus: LD50 = 3060-4060 mg/kg (24H) Oral, mus: LD50 = 2409-3271 mg/kg (10D)
2.Carcinogenicity:3-Amino-5-methylisoxazole(1072-67-9)- Not listed as a carcinogen by NTP, IARC,ACGIH, or CA Prop 65.

3-Amino-5-Methylisoxazole Safety Profile

Hazard Codes:Xi-F,Xi,F,Xn
Risk Statements:
5: Heating may cause an explosion
10: Flammable
11: Highly Flammable
20: Harmful by inhalation
21: Harmful in contact with skin
22: Harmful if swallowed
36: Irritating to the eyes
37: Irritating to the respiratory system
38: Irritating to the skin
Safety Statements:
16: Keep away from sources of ignition - No smoking
22: Do not breathe dust
24: Avoid contact with skin
25: Avoid contact with eyes
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
37: Wear suitable gloves
39: Wear eye/face protection
47: Keep at temperature not exceeding ... E C (to be specified by the manufacturer)

3-Amino-5-Methylisoxazole Specification

Stability and Reactivity of 3-Amino-5-methylisoxazole(1072-67-9):
Conditions to Avoid:Incompatible materials, temperatures above 65°C, ignition sources,light.
Chemical Stability:Stable under normal pressures and temperatures.
Incompatibilities with Other Materials:Strong oxidizing agents.
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide.

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3-Amino-5-Methylisoxazole

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