Hot Products

Basic Information

Post buying leads

Suppliers

Cas Database

Name	4'-Hydroxy-3'-methylacetophenone	EINECS	212-880-5
CAS No.	876-02-8	Density	1.106 g/cm³
PSA	37.30000	LogP	1.90320
Solubility	N/A	Melting Point	107-109 °C(lit.)
Formula	C₉H₁₀O₂	Boiling Point	301.6 °C at 760 mmHg
Molecular Weight	150.177	Flash Point	127.3 °C
Transport Information	N/A	Appearance	white to light beige crystalline powder
Safety	36/37/39-26-22-37/39	Risk Codes	36/37/38-22
Molecular Structure		Hazard Symbols	Xn, Xi
Synonyms	Acetophenone,4'-hydroxy-3'-methyl- (7CI,8CI);1-(3-Methyl-4-hydroxyphenyl)ethanone;1-(4-Hydroxy-3-methylphenyl)ethanone;2-Methyl-4-acetylphenol;3'-Methyl-4'-hydroxyacetophenone;4-Acetyl-2-methylphenol;Ethanone,1-(4-hydroxy-3-methylphenyl)-;NSC 63365;4-Hydroxy-3-methylacetophenone;	Article Data	36

4'-Hydroxy-3'-methylacetophenone Synthetic route

: 95-48-7
ortho-cresol

: 75-36-5
acetyl chloride

: 876-02-8
4-hydroxy-3-methylphenyl methyl ketone

Conditions

Conditions	Yield
With aluminium trichloride In carbon disulfide 1.) RT, 1 h, 2.) reflux, 12 h;	96%
With sublimated iron chloride

: 64-19-7
acetic acid

: 95-48-7
ortho-cresol

A: 876-02-8
4-hydroxy-3-methylphenyl methyl ketone

B: 699-91-2
2-acetyl-6-methylphenol

Conditions

Conditions	Yield
With aluminum oxide; methanesulfonic acid at 140℃; for 5h;	A 92% B 8%
With aluminum oxide; methanesulfonic acid at 140℃; for 0.0833333h;	A 92% B 8%

: 533-18-6
2-methylphenyl acetate

A: 876-02-8
4-hydroxy-3-methylphenyl methyl ketone

B: 699-91-2
2-acetyl-6-methylphenol

Conditions

Conditions	Yield
With aluminum oxide; methanesulfonic acid at 160℃; for 0.166667h;	A 85% B 15%
With potassium carbonate In hexane at 25℃; for 12h; Irradiation;	A 12% B 74%
With zirconium(IV) chloride In dichloromethane for 8h; Ambient temperature; Irradiation;	A 32% B 47%
With aluminum (III) chloride at 120 - 180℃; for 2h; Fries Phenol Ester Rearrangement;

: 64-19-7
acetic acid

: 95-48-7
ortho-cresol

: 876-02-8
4-hydroxy-3-methylphenyl methyl ketone

Conditions

Conditions	Yield
Stage #1: acetic acid With trifluoromethylsulfonic anhydride at 20 - 60℃; Stage #2: ortho-cresol at 60℃; for 0.166667h; regiospecific reaction;	83%

: 533-18-6
2-methylphenyl acetate

: 876-02-8
4-hydroxy-3-methylphenyl methyl ketone

Conditions

Conditions	Yield
With aluminium trichloride In nitromethane at 50℃; Fries rearrangement;	76%
With N,N-dimethyl-formamide; zinc at 68℃; for 5h; Fries rearrangement; microwave irradiation;	74%
With aluminum (III) chloride at 25 - 165℃; for 2h;	28%

: 43230-11-1
4'-amino-3'-methyl-acetophenone

: 876-02-8
4-hydroxy-3-methylphenyl methyl ketone

Conditions

Conditions	Yield
With hydrogenchloride; sodium nitrite durch Erhitzen der Diazoniumsalzloesung;

: 103262-79-9
1-ethynyl-4-methyl-cyclohexa-2,5-diene-1,4-diol

: 876-02-8
4-hydroxy-3-methylphenyl methyl ketone

Conditions

Conditions	Yield
With sulfuric acid

: 95-48-7
ortho-cresol

: 75-36-5
acetyl chloride

A: 876-02-8
4-hydroxy-3-methylphenyl methyl ketone

B: 699-91-2
2-acetyl-6-methylphenol

Conditions

Conditions	Yield
With titanium tetrachloride; nitrobenzene at 30℃;

: 95-48-7
ortho-cresol

: 75-05-8
acetonitrile

: 876-02-8
4-hydroxy-3-methylphenyl methyl ketone

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid 1.) room temperature, 1.5-3.5 h, 2.) 14 d; Yield given. Multistep reaction;

: 95-48-7
ortho-cresol

: 876-02-8
4-hydroxy-3-methylphenyl methyl ketone

Conditions

Conditions	Yield
titanium tetrachloride
Multi-step reaction with 2 steps 1: sulfuric acid / 0.5 h / 20 °C 2: aluminum (III) chloride / 2 h / 120 - 180 °C View Scheme

4'-Hydroxy-3'-methylacetophenone Chemical Properties

Molecular Structure of 4-Hydroxy-3-methylacetophenone (CAS NO.876-02-8):

Molecular formula: C₉H₁₀O₂
Molecular Weight: 150.17
EINECS: 212-880-5
Melting point: 107-109 ^°C(lit.)
Boiling Point: 301.6 °C at 760 mmHg
Flash Point: 127.3 °C
Index of Refraction: 1.546
Molar Refractivity: 42.98 cm³
Molar Volume: 135.6 cm³
Polarizability: 17.04 10^-24 cm³
Surface Tension: 41.8 dyne/cm
Density: 1.106 g/cm³
Enthalpy of Vaporization: 56.34 kJ/mol
Vapour Pressure: 0.000585 mmHg at 25°C
BRN: 2041839
Physical Appearance: white to light beige crystalline powder
Product Categories: Aromatic Acetophenones & Derivatives (substituted);Benzene series;Benzene derivatives;C9;Carbonyl Compounds;Ketones
IUPAC Name: 1-(4-hydroxy-3-methylphenyl)ethanone
Synonyms: Ethanone, 1-(4-hydroxy-3-methylphenyl)-;4-ACETYL-2-METHYLPHENOL;4-HYDROXY-3-METHYLACETOPHENONE;1-(4-HYDROXY-3-METHYLPHENYL)ETHANONE;3'-Methyl-4'-Hydroxy Acetophenone;4'-Hydroxy-3'-methylacetophenone, 99.5+%;1-(4-HYDROXY-3-METHYLPHENYL)ETHAN-1-ONE;4'-HYDROXY-3'-METHYLACETOPHENONE;

4'-Hydroxy-3'-methylacetophenone Safety Profile

Hazard Codes: Irritant Xi, Harmful Xn
Risk Statements: 36/37/38-22
R36/37/38:Irritating to eyes, respiratory system and skin.
R22:Harmful if swallowed.
Safety Statements: 36/37/39-26-22-37/39
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S22:Do not breathe dust.
S37/39:Wear suitable gloves and eye/face protection.
WGK Germany: 3
Hazard Note: Irritant
HazardClass: IRRITANT

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 876-02-8