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Cas Database |
| Name |
4-Hydroxyquinoline |
EINECS | 210-268-2 |
| CAS No. | 611-36-9 | Density | 1.188 g/cm3 |
| PSA | 33.12000 | LogP | 1.94040 |
| Solubility | soluble in alcohol, slightly soluble in water | Melting Point |
200-202 °C(lit.) |
| Formula | C9H7NO | Boiling Point | 261.5 °C at 760 mmHg |
| Molecular Weight | 145.161 | Flash Point | 122.3 °C |
| Transport Information | N/A | Appearance | light yellow and off-white crystal powder |
| Safety | 26-36-37/39 | Risk Codes | 36/37/38 |
| Molecular Structure |
|
Hazard Symbols |
 Xi
|
| Synonyms |
Quinoline, 4-hydroxy-;4-Quinolinol;4-Hydroxy Quinoline;Kynurine;Quinolin-4-ol;4-Quinolinol (8CI,9CI); |
Article Data | 20 |
4-Hydroxyquinoline Synthetic route
- 101273-58-9
4-(phenylmethoxy)quinoline
- 611-36-9
quinolin-4-ol
| Conditions | Yield |
|---|---|
| With tris(bipyridine)ruthenium(II) dichloride hexahydrate; ascorbic acid In water; acetonitrile at 20℃; for 1h; Schlenk technique; Irradiation; Inert atmosphere; chemoselective reaction; | 99% |
- 34785-11-0
4-hydroxy-3-quinoline carboxylic acid
- 611-36-9
quinolin-4-ol
| Conditions | Yield |
|---|---|
| In diphenylether for 1h; Reflux; | 97% |
- 21617-15-2
7-chloro-1,2,3,4-tetrahydroquinolin-4-one
A
- 86-99-7
7-chloro-4-hydroxylquinoline
B
- 611-36-9
quinolin-4-ol
| Conditions | Yield |
|---|---|
| A 88.3% B n/a |
- 611-36-9
quinolin-4-ol
| Conditions | Yield |
|---|---|
| With lithium diisopropyl amide In tetrahydrofuran at 0℃; for 0.0833333h; | 72% |
- 611-36-9
quinolin-4-ol
| Conditions | Yield |
|---|---|
| With lithium diisopropyl amide In tetrahydrofuran at 0℃; for 0.0833333h; | 68% |
- 15568-92-0
5-(N-phenyl)-aminomethylene-2,2-dimethyl-1,3-dioxane-4,6-dione
- 611-36-9
quinolin-4-ol
| Conditions | Yield |
|---|---|
| In tetrahydrofuran at 300℃; under 75007.5 Torr; for 0.025h; Gould-Jacobs type cyclization; Flash vacuum pyrolysis; Autoclave; regioselective reaction; | 60% |
- 521270-78-0
1-(2-isocyanophenyl)ethan-1-one
- 611-36-9
quinolin-4-ol
| Conditions | Yield |
|---|---|
| With copper(l) iodide; 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 20℃; for 6h; Reagent/catalyst; Solvent; chemoselective reaction; | 57% |
- 1613-37-2
Quinoline N-oxide
A
- 91-22-5
quinoline
B
- 611-36-9
quinolin-4-ol
C
- 119-91-5
2,2'-biquinoline
D
- 27080-08-6, 34281-95-3
4-(quinolin-4-yl)quinoline
| Conditions | Yield |
|---|---|
| With naphthalene In tetrahydrofuran for 24h; | A n/a B 32% C 20% D n/a |
- 1613-37-2
Quinoline N-oxide
- 79-36-7
dichloroacethyl chloride
A
- 4032-52-4
2-(dichloromethyl)quinoline
B
- 611-36-9
quinolin-4-ol
C
- 88237-18-7
bis(2-quinolyl)dichloromethane
| Conditions | Yield |
|---|---|
| With triethylamine In chloroform 2 h, r.t; 9 h; | A 12.4% B 4.6% C 5.4% |
- 1613-37-2
Quinoline N-oxide
A
- 4032-52-4
2-(dichloromethyl)quinoline
B
- 611-36-9
quinolin-4-ol
C
- 88237-18-7
bis(2-quinolyl)dichloromethane
| Conditions | Yield |
|---|---|
| With dichloroacethyl chloride; triethylamine In chloroform 2 h, r.t; 9 h; | A 12.4% B 4.6% C 5.4% |
4-Hydroxyquinoline Chemical Properties
Molecule structure of 4-Hydroxyquinoline (CAS NO.611-36-9):
IUPAC Name: 1H-Quinolin-4-one
Molecular Formula: C9H7NO
Molecular Weight: 145.157980 g/mol
Density: 1.188 g/cm3
Melting Point: 202-206 °C
Boiling Point: 261.5 °C at 760 mmHg
Flash Point: 122.3 °C
Index of Refraction: 1.595
Molar Refractivity: 41.5 cm3
Molar Volume: 122 cm3
Polarizability: 16.45×10-24 cm3
Surface Tension: 43.5 dyne/cm
Solubility: soluble in alcohol, slightly soluble in water
XLogP3: 0.6
H-Bond Donor: 1
H-Bond Acceptor: 2
Tautomer Count: 3
Exact Mass: 145.052764
MonoIsotopic Mass: 145.052764
Topological Polar Surface Area: 29.1
Heavy Atom Count: 11
Complexity: 198
Canonical SMILES: C1=CC=C2C(=C1)C(=O)C=CN2
InChI: InChI=1S/C9H7NO/c11-9-5-6-10-8-4-2-1-3-7(8)9/h1-6H,(H,10,11)
InChIKey: PMZDQRJGMBOQBF-UHFFFAOYSA-N
EINECS:210-268-2
Product Categories: Alcohols and Derivatives; Heterocycles; Quinolines, Quinazolines and derivatives; Heterocyclic Series; Quinoline&Isoquinoline; Quinolines; Hydroxyquinolines; quinoline
4-Hydroxyquinoline Uses
4-Hydroxyquinoline (611-36-9) is used for pharmaceutical intermediates.
4-Hydroxyquinoline Safety Profile
Hazard Codes: 
Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S37/39:Wear suitable gloves and eye/face protection.
WGK Germany: 3
RTECS: VC4070000
4-Hydroxyquinoline Specification
4-Hydroxyquinoline (CAS NO.611-36-9) is also named as BRN 1524969 ; CCRIS 4329 ; Kynurine ; NSC 3183 ; Quinoline, 4-hydroxy- . 4-Hydroxyquinoline (CAS NO.611-36-9) is light beige to yellowish crystal powder or needles.
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