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4-Piperidineethanol
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Name

4-Piperidineethanol

 EINECS 210-727-7
CAS No. 622-26-4 Density 0.939 g/cm3
PSA 32.26000 LogP 0.69720
Solubility N/A Melting Point 46-47 °C(lit.)
Formula C7H15NO Boiling Point 228.3 °C at 760 mmHg
Molecular Weight 129.202 Flash Point 101.7 °C
Transport Information N/A Appearance white crystalline low melting solid
Safety 26-37/39-24/25 Risk Codes 36/37/38
Molecular Structure Molecular Structure of 622-26-4 (4-Piperidineethanol) Hazard Symbols IrritantXi
Synonyms

2-(4-Piperidyl)ethanol;2-(Piperidin-4-yl)-1-ethanol;2-(Piperidin-4-yl)ethanol;4-(2-Hydroxyethyl)piperidine;NSC 93818;

Article Data 14

4-Piperidineethanol Synthetic route

383865-57-4

4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl-amine

A

622-26-4

4-(2-Hydroxyethyl)piperidine

B

4-(2-Hydroxy-ethyl)-piperidine-1-carboxylic acid (4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide

Conditions
ConditionsYield
A n/a
B 64%
51052-78-9

4-piperidinylacetic acid

622-26-4

4-(2-Hydroxyethyl)piperidine

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran at 25℃; Cooling with ice; Inert atmosphere;62.5%
5344-27-4

4-(2-hydroxyethyl)pyridine

622-26-4

4-(2-Hydroxyethyl)piperidine

Conditions
ConditionsYield
With sodium; butan-1-ol und Hydrieren des vermutlich als 2-<1,2,3,6-Tetrahydro-<4>pyridyl>-aethanol C7H13NO zu formulierenden Reaktionsprodukts in Essigsaeure an Palladium;
With acetic acid; platinum Hydrogenation;
28356-58-3

pyridine-4-acetic acid

622-26-4

4-(2-Hydroxyethyl)piperidine

Conditions
ConditionsYield
With platinum on activated charcoal; dimethylsulfide borane complex; hydrogen 2.) 1 atm; Multistep reaction;
4-<β-oxy-ethyl>-pyridine

4-<β-oxy-ethyl>-pyridine

622-26-4

4-(2-Hydroxyethyl)piperidine

Conditions
ConditionsYield
With ethanol; sodium
872850-91-4

2-(1,2,3,6-tetrahydro-[4]pyridyl)-ethanol

64-19-7

acetic acid

palladium

palladium

622-26-4

4-(2-Hydroxyethyl)piperidine

Conditions
ConditionsYield
Hydrogenation;
175213-46-4

1-t-Butoxycarbonyl-4-(methoxycarbonylmethyl)piperidine

622-26-4

4-(2-Hydroxyethyl)piperidine

Conditions
ConditionsYield
With carbonylhydrido(tetrahydroborato)[bis(2-diphenylphosphinoethyl)-amino]ruthenium(II); hydrogen; sodium methylate In methanol at 100℃; under 38002.6 Torr; for 12h; Reagent/catalyst;
622-26-4

4-(2-Hydroxyethyl)piperidine

24424-99-5

di-tert-butyl dicarbonate

89151-44-0

4-(2-hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
With sodium hydroxide In tert-butyl alcohol at 23℃; for 30h;100%
With triethylamine In chloroform at 0 - 20℃; for 1h;100%
With sodium hydroxide In water; tert-butyl alcohol at 10 - 23℃;100%
622-26-4

4-(2-Hydroxyethyl)piperidine

162046-62-0

2-methoxy-pyridin-3-ylmethyl chloride

351410-17-8

1-[(2-methoxy-pyridin-3-yl)methyl]-4-piperidineethanol

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 2h;100%
622-26-4

4-(2-Hydroxyethyl)piperidine

34619-03-9

tert-butyldicarbonate

89151-44-0

4-(2-hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
In tetrahydrofuran at 20℃;100%
In methanol at 20℃; for 2h; Inert atmosphere;95%
In dichloromethane at 20℃;52 g

4-Piperidineethanol Specification

The CAS register number of 4-Piperidineethanol is 622-26-4. It also can be called as 4-(2-Hydroxyethyl)piperidine and the IUPAC name about this chemical is 2-piperidin-4-ylethanol. The molecular formula about this chemical is C7H15NO and the molecular weight is 129.20. It belongs to the Piperidine. If you want to store this chemical, please keep containers tightly closed and store it in a cool, dry, well-ventilated area away from incompatible substances.

Physical properties about 4-Piperidineethanol are: (1)ACD/LogP: -0.05; (2)ACD/LogD (pH 5.5): -3.15; (3)ACD/LogD (pH 7.4): -3.05; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 2; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 3; (11)Polar Surface Area: 12.47Å2; (12)Index of Refraction: 1.454; (13)Molar Refractivity: 37.26 cm3; (14)Molar Volume: 137.5 cm3; (15)Polarizability: 14.77x10-24cm3; (16)Surface Tension: 34.6 dyne/cm; (17)Enthalpy of Vaporization: 54.04 kJ/mol; (18)Boiling Point: 228.3 °C at 760 mmHg; (19)Vapour Pressure: 0.0144 mmHg at 25°C.

Uses of 4-Piperidineethanol: it can be used to produce N-formyl-4-(2-hydroxyethyl)piperidine with formic acid methyl ester at temperature of 0 - 20 ℃. This reaction time is 1 hours. The yield is about 95%.

When you are using this chemical, please be cautious about it as the following:
This chemical is irritating to eyes, respiratory system and skin. When you are using it, wear suitable gloves and eye/face protection, you also need avoid contact with skin and eyes. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice

You can still convert the following datas into molecular structure:
(1)SMILES: OCCC1CCNCC1
(2)InChI: InChI=1/C7H15NO/c9-6-3-7-1-4-8-5-2-7/h7-9H,1-6H2
(3)InChIKey: LDSQQXKSEFZAPE-UHFFFAOYAB
(4)Std. InChI: InChI=1S/C7H15NO/c9-6-3-7-1-4-8-5-2-7/h7-9H,1-6H2
(5)Std. InChIKey: LDSQQXKSEFZAPE-UHFFFAOYSA-N

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