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Cas Database |
| Name |
5-Bromo-2-iodopyridine |
EINECS | -0 |
| CAS No. | 223463-13-6 | Density | 2.347 g/cm3 |
| PSA | 12.89000 | LogP | 2.44870 |
| Solubility | N/A | Melting Point |
113-117 °C(lit.) |
| Formula | C5H3BrIN | Boiling Point | 258.8 °C at 760 mmHg |
| Molecular Weight | 283.894 | Flash Point | 110.3 °C |
| Transport Information | N/A | Appearance | Light yellow cryst. |
| Safety | 26-36-37/39 | Risk Codes | 36/37/38 |
| Molecular Structure |
|
Hazard Symbols |
 Xi
|
| Synonyms |
2-Iodo-5-Bromopyridine;2-Iodo-5-Fluoropyridine;5-Bromo-2-idiopyridine;5-bromo-2-iodo-pyridine;5-bromo-2-iodo pyridine; |
Article Data | 17 |
5-Bromo-2-iodopyridine Synthetic route
- 624-28-2
2,5-dibromopyridine
- 223463-13-6
2-iodo-5-bromopyridine
| Conditions | Yield |
|---|---|
| With hydrogen iodide at 100 - 170℃; for 20h; | 95% |
| With hydrogen iodide; potassium iodide for 72h; Reflux; | 90% |
| With chloro-trimethyl-silane; sodium iodide In various solvent(s) for 125h; Heating; | 87% |
- 223463-13-6
2-iodo-5-bromopyridine
| Conditions | Yield |
|---|---|
| With phosphorus trichloride In dichloromethane for 1h; Reflux; | 75% |
- 1072-97-5
5-bromo-2-pyridylamine
- 223463-13-6
2-iodo-5-bromopyridine
| Conditions | Yield |
|---|---|
| With N-iodo-succinimide; sodium nitrite In N,N-dimethyl-formamide at 20℃; for 4h; | 72% |
| With acetic acid; potassium iodide; sodium nitrite |
- 624-28-2
2,5-dibromopyridine
A
- 73290-22-9
2-bromo-5-iodo-pyridine
B
- 116195-81-4
2,5-di-iodopyridine
C
- 223463-13-6
2-iodo-5-bromopyridine
| Conditions | Yield |
|---|---|
| Stage #1: 2,5-dibromopyridine With nBu4ZnLi2*TMEDA In toluene at 20℃; for 1h; Inert atmosphere; Stage #2: With iodine In tetrahydrofuran; toluene for 18h; Inert atmosphere; | A 41 %Spectr. B 13 %Spectr. C 23 %Spectr. |
| Conditions | Yield |
|---|---|
| Stage #1: 2,5-dibromopyridine With nBu4ZnLi2 In toluene at 20℃; for 1h; Inert atmosphere; Stage #2: With iodine In tetrahydrofuran; toluene for 18h; Inert atmosphere; | A 8 %Spectr. B 80 %Spectr. |
- 696-15-1
2-amino-5-bromopyridine 1-oxide
- 223463-13-6
2-iodo-5-bromopyridine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: toluene-4-sulfonic acid; potassium iodide; sodium nitrite / water / 3 h / 20 °C 2: phosphorus trichloride / dichloromethane / 1 h / Reflux View Scheme |
- 223463-13-6
2-iodo-5-bromopyridine
- 30418-59-8
3-Aminophenylboronic acid
- 1191616-42-8
3-(5-bromopyridin-2-yl)aniline
| Conditions | Yield |
|---|---|
| With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water at 100℃; Suzuki Coupling; Sealed tube; | 100% |
- 223463-13-6
2-iodo-5-bromopyridine
- 68-12-2, 33513-42-7
N,N-dimethyl-formamide
- 31181-90-5
5-bromo-pyridine-2-carbaldehyde
| Conditions | Yield |
|---|---|
| Stage #1: 2-iodo-5-bromopyridine With isopropylmagnesium chloride In tetrahydrofuran at -15 - -5℃; for 1h; Stage #2: N,N-dimethyl-formamide In tetrahydrofuran at -5 - 25℃; for 1.5h; | 99% |
| With isopropylmagnesium chloride In tetrahydrofuran at -10℃; | 94% |
| Stage #1: 2-iodo-5-bromopyridine With isopropylmagnesium chloride In tetrahydrofuran at -15 - 0℃; for 1h; Stage #2: N,N-dimethyl-formamide In dichloromethane at 0 - 20℃; for 1.5h; Stage #3: With hydrogenchloride In tetrahydrofuran for 0.5h; below 25 deg C; | 90% |
| Conditions | Yield |
|---|---|
| With potassium carbonate In 1,2-dimethoxyethane at 100℃; for 24h; Suzuki Coupling; | 99% |
| With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In ethanol; water; toluene for 2h; Inert atmosphere; Reflux; | 95% |
| With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In ethanol; water; benzene for 2h; Reflux; | 94.43% |
- 223463-13-6
2-iodo-5-bromopyridine
- 201802-67-7
4-(diphenylamino)phenyl boronic acid
- 1257900-36-9
4-(5-bromopyridin-2-yl)-N,N-diphenylaniline
| Conditions | Yield |
|---|---|
| With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran; water at 80℃; for 19h; Inert atmosphere; | 98% |
| With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In tetrahydrofuran; water at 80℃; for 20.5h; Inert atmosphere; | 98% |
5-Bromo-2-iodopyridine Chemical Properties
IUPAC Name: 5-bromo-2-iodopyridine
Empirical Formula: C5H3BrIN
Molecular Weight: 283.8925
Structure of 5-Bromo-2-iodopyridine (CAS NO.223463-13-6):
Index of Refraction: 1.665
Molar Refractivity: 44.94 cm3
Molar Volume: 120.9 cm3
Polarizability: 17.81×10-24cm3
Surface Tension: 53.8 dyne/cm
Density: 2.347 g/cm3
Flash Point: 110.3 °C
Enthalpy of Vaporization: 47.63 kJ/mol
Melting Point: 113-117 °C(lit.)
Boiling Point: 258.8 °C at 760 mmHg
Vapour Pressure: 0.0218 mmHg at 25°C
Sensitive: Light Sensitive
Product Categories: blocks;Bromides;Iodides;Pyridines;Pyridine;pyridine derivative;Pyridine Series;Halides;Heterocycles;Pyridines derivates;Heterocycle;Bromopyridines;Halopyridines;Iodopyridines;C5Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks
Canonical SMILES: C1=CC(=NC=C1Br)I
InChI: InChI=1S/C5H3BrIN/c6-4-1-2-5(7)8-3-4/h1-3H
InChIKey: HSNBRDZXJMPDGH-UHFFFAOYSA-N
5-Bromo-2-iodopyridine Safety Profile
Hazard Codes: 
Xi
Hazard Note:Irritant
Risk Statements:
36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements:
26: In case of contact with eyes, rinse immediately with plenty of WATER and seek medical advice
36: Wear suitable protective clothing
37/39: Wear suitable gloves and eye/face protection
5-Bromo-2-iodopyridine Specification
5-Bromo-2-iodopyridine , its cas register number is 223463-13-6. It also can be called 2-Iodo-5-Bromopyridine ; 5-Brom-2-iodpyridin ; pyridine, 5-bromo-2-iodo- . 5-Bromo-2-iodopyridine (CAS NO.223463-13-6) is a light yellow cryst.
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