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Cas Database |
| Name |
6-Azauridine |
EINECS | 200-199-6 |
| CAS No. | 54-25-1 | Density | 2.08 g/cm3 |
| PSA | 137.67000 | LogP | -3.45690 |
| Solubility | It is soluble in water. | Melting Point |
157-159 °C(lit.) |
| Formula | C8H11 N3 O6 | Boiling Point | °Cat760mmHg |
| Molecular Weight | 245.192 | Flash Point | °C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Moderately toxic by intraperitoneal route. Human teratogenic effects by intravenous route: unspecified developmental abnormalities or effects on the embryo or fetus. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. Used as an antineoplastic agent. | Risk Codes | 20/21/22-40 |
| Molecular Structure |
|
Hazard Symbols |
 Xn
|
| Synonyms |
as-Triazine-3,5(2H,4H)-dione,2-b-D-ribofuranosyl- (6CI,7CI,8CI);2-b-D-Ribofuranosyl-as-triazine-3,5(2H,4H)-dione;6-Azauracil 1-riboside; 6-Azauracil riboside; 6-Azauracil-b-D-riboside; 6-Azauridine;6-Azur; 6-Azuridine; AzUR; Azauridine; NSC 32074; Rib-Azauracil; Ribo-azuracil;Riboazauracil; ribo-Azauracil |
Article Data | 16 |
6-Azauridine Chemical Properties
Molecular Formula: C8H11N3O6
Molar mass: 245.1894 g/mol
EINECS: 200-199-6
Density: 2.08 g/cm3
Index of Refraction: 1.795
Melting point: 157-159 °C(lit.)
Storage temp: 2-8°C
Product categories of 6-Azauridine (CAS NO.54-25-1): Biochemistry;Antibiotic Explorer;Nucleosides and their analogs;Pyridines, Pyrimidines, Purines and Pteredines;Nucleosides, Nucleotides & Related Reagents
Structure of 6-Azauridine (CAS NO.54-25-1):
XLogP3-AA: -2.1
H-Bond Donor: 4
H-Bond Acceptor: 7
IUPAC Name: 2-[3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazine-3,5-dione
Canonical SMILES: C1=NN(C(=O)NC1=O)C2C(C(C(O2)CO)O)O
InChI: InChI=1S/C8H11N3O6/c12-2-3-5(14)6(15)7(17-3)11-8(16)10-4(13)1-9-11/h1,3,5-7,12,14-15H,2H2,(H,10,13,16)
InChIKey: WYXSYVWAUAUWLD-UHFFFAOYSA-N
6-Azauridine Toxicity Data With Reference
| 1. | sln-dmg-par 20 mmol/L | BCPCA6 Biochemical Pharmacology. 15 (1966),299. | ||
| 2. | spm-rat-ipr 2 g/kg | CEFYAD Ceskoslovenska Fysiologie. 21 (1972),278. | ||
| 3. | dni-mus-ipr 3 g/kg | NEOLA4 Neoplasma. 20 (1973),243. | ||
| 4. | spm-mus-ipr 5 g/kg | CEFYAD Ceskoslovenska Fysiologie. 21 (1972),278. | ||
| 5. | ivn-wmn TDLo:150 mg/kg (47D preg):TER | CLPTAT Clinical Pharmacology and Therapeutics. 7 (1966),162. | ||
| 6. | ipr-rat LD50:9400 mg/kg | TJADAB Teratology, A Journal of Abnormal Development. 4 (1971),287. | ||
| 7. | ipr-mus LD50:11,250 mg/kg | BCPCA6 Biochemical Pharmacology. 14 (1965),1517. | ||
| 8. | ipr-dog LD50:3400 mg/kg | BCPCA6 Biochemical Pharmacology. 14 (1965),1537. | ||
| 9. | ipr-cat LD50:2400 mg/kg | BCPCA6 Biochemical Pharmacology. 14 (1965),1537. |
6-Azauridine Consensus Reports
EPA Genetic Toxicology Program.
6-Azauridine Safety Profile
Moderately toxic by intraperitoneal route. Human teratogenic effects by intravenous route: unspecified developmental abnormalities or effects on the embryo or fetus. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. Used as an antineoplastic agent.
Hazard Codes: 
Xn
Risk Statements:
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
R40:Limited evidence of a carcinogenic effect.
Safety Statements:
S22:Do not breathe dust.
S36:Wear suitable protective clothing.
6-Azauridine Specification
6-Azauridine ,its cas register number is 54-25-1. It also can be called 6-Azauracil Ribozide ; ribo-Azauracil ; 2-(beta-D-Ribofuranosyl)-1,2,4-triazine-3,5(2H,4H)-dione ; 2-b-D-Ribofuranosyl-1,2,4-triazine-3,5(2H,4H)-dione ; 2-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2H--[1,2,4]triazine-3,5-dione and 1,2,4-triazine-3,5(2H,4H)-dione, 2-beta-D-ribofuranosyl- .
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