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| CAS No.: | 7220-81-7 |
|---|---|
| Name: | AFLATOXIN B2 |
| Molecular Structure: | |
|
|
|
| Formula: | C17H14 O6 |
| Molecular Weight: | 314.295 |
| Synonyms: | AflatoxinB2 (7CI); Cyclopenta[c]furo[3',2':4,5]furo[2,3-h][1]benzopyran-1,11-dione,2,3,6a,8,9,9a-hexahydro-4-methoxy-, (6aR-cis)-;Cyclopenta[c]furo[3',2':4,5]furo[2,3-h][1]benzopyran-1,11-dione, 2,3,6aa,8,9,9aa-hexahydro-4-methoxy- (8CI);Dihydroaflatoxin B1; Dihydroaflatoxine B1 |
| EINECS: | 230-618-8 |
| Density: | 1.52 g/cm3 |
| Melting Point: | 286-289 °C |
| Boiling Point: | 521 °C at 760 mmHg |
| Flash Point: | 234 °C |
| Solubility: | 15mg/L(temperature not stated) |
| Hazard Symbols: |
 T+
|
| Risk Codes: | 45-26/27/28 |
| Safety: | Confirmed human carcinogen with experimental tumorigenic data. Poison by ingestion. Mutation data reported. When heated to decomposition it emits acrid smoke and fumes. See also various aflatoxins. |
| Transport Information: | UN 3462 6 |
| PSA: | 74.97000 |
| LogP: | 2.15290 |
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ethyl 2-bromo-5-oxocyclopent-1-enecarboxylate
- 7220-81-7
aflatoxin B2
| Conditions | Yield |
|---|---|
| With sodium hydrogencarbonate; zinc(II) carbonate In dichloromethane at 20℃; for 20h; | 36% |
| Conditions | Yield |
|---|---|
| With hydrogenchloride; sodium hydroxide; LACTIC ACID at 37℃; pH=3.35 - 4.50; Kinetics; Further Variations:; reagents concentration; |
- 865811-99-0
(-)-cis-5-trifluoromethanesulfonyloxy-2,3,3aS,8aR-tetrahydro-6-methoxy[2,3-d]-benzo[b]furan-4-carboxaldehyde
- 7220-81-7
aflatoxin B2
| Conditions | Yield |
|---|---|
| Multi-step reaction with 5 steps 1: tetrahydrofuran; diethyl ether / 2 h / -20 °C 2: 162 mg / Dess-Martin periodinane / CH2Cl2 / 3 h / 20 °C 3: 62.5 percent / urea-H2O2 complex; trifluoroacetic anhydride / CH2Cl2 / 48 h / 20 °C 4: 60 percent / H2; Raney nickel / methanol / 3 h / 20 °C 5: 36 percent / NaHCO3; ZnCO3 / CH2Cl2 / 20 h / 20 °C View Scheme |
- 865812-13-1
acetic acid 6-methoxy-5-trifluoromethanesulfonyloxy-2,3,3a,8a-tetrahydro-1,8-dioxa-cyclopenta[a]inden-4-yl ester
- 7220-81-7
aflatoxin B2
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 60 percent / H2; Raney nickel / methanol / 3 h / 20 °C 2: 36 percent / NaHCO3; ZnCO3 / CH2Cl2 / 20 h / 20 °C View Scheme |
- 7220-81-7
aflatoxin B2
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1: 162 mg / Dess-Martin periodinane / CH2Cl2 / 3 h / 20 °C 2: 62.5 percent / urea-H2O2 complex; trifluoroacetic anhydride / CH2Cl2 / 48 h / 20 °C 3: 60 percent / H2; Raney nickel / methanol / 3 h / 20 °C 4: 36 percent / NaHCO3; ZnCO3 / CH2Cl2 / 20 h / 20 °C View Scheme |
- 865812-00-6
(-)-cis-5-trifluoromethanesulfonyloxy-2,3,3aS,8aR-tetrahydro-4-acetyl-6-methoxy[2,3-d]-benzo[b]furan
- 7220-81-7
aflatoxin B2
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: 62.5 percent / urea-H2O2 complex; trifluoroacetic anhydride / CH2Cl2 / 48 h / 20 °C 2: 60 percent / H2; Raney nickel / methanol / 3 h / 20 °C 3: 36 percent / NaHCO3; ZnCO3 / CH2Cl2 / 20 h / 20 °C View Scheme |
| Conditions | Yield |
|---|---|
| Multi-step reaction with 8 steps 1.1: (R)-α,α-diphenyl-2-pyrrolidinemethanol derived catalyst / acetonitrile / 5 h / 20 °C 2.1: AcOH / 48 h / 110 °C 2.2: 40 percent / aq. H2SO4 / 1 h / 75 °C 3.1: 80 percent / DMAP; pyridine / CH2Cl2 / 2 h / 0 °C 4.1: tetrahydrofuran; diethyl ether / 2 h / -20 °C 5.1: 162 mg / Dess-Martin periodinane / CH2Cl2 / 3 h / 20 °C 6.1: 62.5 percent / urea-H2O2 complex; trifluoroacetic anhydride / CH2Cl2 / 48 h / 20 °C 7.1: 60 percent / H2; Raney nickel / methanol / 3 h / 20 °C 8.1: 36 percent / NaHCO3; ZnCO3 / CH2Cl2 / 20 h / 20 °C View Scheme | |
| Multi-step reaction with 8 steps 1.1: (R)-α,α-diphenyl-2-pyrrolidinemethanol derived catalyst / acetonitrile; CH2Cl2 / 10 h / -78 - 20 °C 2.1: AcOH / 48 h / 110 °C 2.2: 40 percent / aq. H2SO4 / 1 h / 75 °C 3.1: 80 percent / DMAP; pyridine / CH2Cl2 / 2 h / 0 °C 4.1: tetrahydrofuran; diethyl ether / 2 h / -20 °C 5.1: 162 mg / Dess-Martin periodinane / CH2Cl2 / 3 h / 20 °C 6.1: 62.5 percent / urea-H2O2 complex; trifluoroacetic anhydride / CH2Cl2 / 48 h / 20 °C 7.1: 60 percent / H2; Raney nickel / methanol / 3 h / 20 °C 8.1: 36 percent / NaHCO3; ZnCO3 / CH2Cl2 / 20 h / 20 °C View Scheme |
- 292824-29-4
(-)-2,3,3aS,8aR-tetrahydro-5-hydroxy-6-methoxy[2,3-d]-benzo[b]furan
- 7220-81-7
aflatoxin B2
| Conditions | Yield |
|---|---|
| Multi-step reaction with 7 steps 1.1: AcOH / 48 h / 110 °C 1.2: 40 percent / aq. H2SO4 / 1 h / 75 °C 2.1: 80 percent / DMAP; pyridine / CH2Cl2 / 2 h / 0 °C 3.1: tetrahydrofuran; diethyl ether / 2 h / -20 °C 4.1: 162 mg / Dess-Martin periodinane / CH2Cl2 / 3 h / 20 °C 5.1: 62.5 percent / urea-H2O2 complex; trifluoroacetic anhydride / CH2Cl2 / 48 h / 20 °C 6.1: 60 percent / H2; Raney nickel / methanol / 3 h / 20 °C 7.1: 36 percent / NaHCO3; ZnCO3 / CH2Cl2 / 20 h / 20 °C View Scheme |
- 292824-31-8
(-)-2,3,3aS,8aR-tetrahydro-5-hydroxy-6-methoxy[2,3-d]-benzo[b]furan-4-carboxaldehyde
- 7220-81-7
aflatoxin B2
| Conditions | Yield |
|---|---|
| Multi-step reaction with 6 steps 1: 80 percent / DMAP; pyridine / CH2Cl2 / 2 h / 0 °C 2: tetrahydrofuran; diethyl ether / 2 h / -20 °C 3: 162 mg / Dess-Martin periodinane / CH2Cl2 / 3 h / 20 °C 4: 62.5 percent / urea-H2O2 complex; trifluoroacetic anhydride / CH2Cl2 / 48 h / 20 °C 5: 60 percent / H2; Raney nickel / methanol / 3 h / 20 °C 6: 36 percent / NaHCO3; ZnCO3 / CH2Cl2 / 20 h / 20 °C View Scheme |
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Chemistry
Product Name: Aflatoxin B2 (CAS NO.7220-81-7)
Molecular Formula: C17H14O6
Molecular Weight: 314.29g/mol
Mol File: 7220-81-7.mol
Einecs: 230-618-8
Appearance: Off-white powder
Melting Point: 286-289 °C
Boiling point: 521 °C at 760 mmHg
Storage Temperature: 2-8°C
Flash Point: 234.1 °C
Density: 1.52 g/cm3
Surface Tension: 65.6 dyne/cm
Enthalpy of Vaporization: 79.41 kJ/mol
Vapour Pressure: 5.92E-11 mmHg at 25°C
XLogP3-AA: 1.3
H-Bond Donor: 0
H-Bond Acceptor: 6
Product Categories: Biotoxins; Mycotoxins; Single component solutions; Cancer Research; CarcinogensCell Signaling and Neuroscience; Mold; Toxins and Venoms; CRM and Matrix RMApplication CRMs; A; AA to ALBiotoxins; Alphabetic; Food and Agriculture CRM; Other
Toxicity Data With Reference
| 1. | mma-sat 370 ng/plate | MUREAV Mutation Research. 130 (1984),79. | ||
| 2. | dnd-rat-par 40 µg/kg/2D-C | BBRCA9 Biochemical and Biophysical Research Communications. 83 (1978),1354. | ||
| 3. | sce-ham:lng 3100 µg/L | CRNGDP Carcinogenesis. 1 (1980),759. | ||
| 4. | dnd-mam:lym 50 µmol/L | CRNGDP Carcinogenesis. 3 (1982),423. | ||
| 5. | dns-rat:lvr 10 µmol/L/1H | CNREA8 Cancer Research. 37 (1977),1845. | ||
| 6. | mma-ham:lng 83 µmol/L | MUREAV Mutation Research. 46 (1977),27. | ||
| 7. | orl-dck LD50:1700 µg/kg | NATUAS Nature. 200 (1963),1101. |
Consensus Reports
IARC Cancer Review: Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 10 (1976),p. 51.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 1 (1972),p. 145.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) .
Safety Profile
Confirmed human carcinogen with experimental tumorigenic data. Poison by ingestion. Mutation data reported. When heated to decomposition it emits acrid smoke and fumes. See also various aflatoxins.
Safety Information of Aflatoxin B2 (CAS NO.7220-81-7):
Hazard Codes: T+.gif){kind=small}
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Risk Statements: 45-26/27/28-39/23/24/25-23/24/25-11-65-48/23/24/25-36/38-46-36-20/21/22
11: Highly Flammable
20: Harmful by inhalation
21: Harmful in contact with skin
22: Harmful if swallowed
23: Toxic by inhalation
24: Toxic in contact with skin
25: Toxic if swallowed
26: Very Toxic by inhalation
27: Very Toxic in contact with skin
28: Very Toxic if swallowed
36: Irritating to the eyes
38: Irritating to the skin
39: Danger of very serious irreversible effects
45: May cause cancer
48: Danger of serious damage to health by prolonged exposure
65: Harmful: May cause lung damage if swallowed
Safety Statements: 53-36-45-36/37-26-62
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
37: Wear suitable gloves
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
53: Avoid exposure - obtain special instruction before use
62: If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label
Specification
Aflatoxin B2 ,its CAS NO. is 7220-81-7,the synonyms is (6ar-cis)-Hexahydro-4-methoxy ; ,9,9a-Alpha-hexahydro-4-methoxy- ; 2,3,6Aalpha,8,9,9aalpha-hexahydro-4-methoxycyclopenta(c)furo(3',2':4,5)furo(2,;3-h)(1)benzopyran-1,11-dione ; 4-Methoxy-2,3,6a,8,9,9a-hexahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-H]chromene-1,11-dione ; 9Aalpha-hexahydro-4-methoxy- ; Cyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,11-dione,2,3,6a-alpha,8 .