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| CAS No.: | 1424-27-7 |
|---|---|
| Name: | ACETAZOLAMIDE SODIUM |
| Molecular Structure: | |
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| Formula: | C4H6 N4 O3 S2 . Na |
| Molecular Weight: | 244.24 |
| Synonyms: | 1,3,4-Thiadiazole-2-sulfonamide,5-acetamido-, sodium deriv. (6CI,7CI); Acetamide,N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)-, monosodium salt (8CI); Acetamide,N-[5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl]-, monosodium salt (9CI);Acetazolamide sodium; Acetazolamide sodium salt; Diamox Parenteral; Sodiumacetazolamidate; Sodium acetazolamide; Vetamox |
| Melting Point: | 258-259oC (EFFERVESCENCE) |
| Safety: | An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NOx, Na2O, and SOx. |
| PSA: | 142.87000 |
| LogP: | 0.78380 |
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Chemistry
Molecular Structure of Acetazolamide sodium (CAS NO.1424-27-7):
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IUPAC Name: sodium (5-acetamido-1,3,4-thiadiazol-2-yl)sulfonylazanide
Empirical Formula: C4H5N4NaO3S2
Molecular Weight: 244.2273
Synonyms of Acetazolamide sodium (CAS NO.1424-27-7): Acetazolamide sodium ; acetazolamidesodiumsalt ; diamoxsodium ; n-(5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl)-acetamidmonosodiumsalt ; n-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)-acetamidmonosodiumsalt ; sodiumacetazolamide
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD | intravenous | > 2gm/kg (2000mg/kg) | Bulletin of the Johns Hopkins Hospital. Vol. 95, Pg. 199, 1954. | |
| guinea pig | LDLo | subcutaneous | 1500mg/kg (1500mg/kg) | Bulletin of the Johns Hopkins Hospital. Vol. 95, Pg. 199, 1954. | |
| mouse | LD50 | intravenous | 3gm/kg (3000mg/kg) | Bulletin of the Johns Hopkins Hospital. Vol. 95, Pg. 199, 1954. | |
| rat | LD | oral | > 1gm/kg (1000mg/kg) | Bulletin of the Johns Hopkins Hospital. Vol. 95, Pg. 199, 1954. | |
| rat | LDLo | subcutaneous | 3gm/kg (3000mg/kg) | Bulletin of the Johns Hopkins Hospital. Vol. 95, Pg. 199, 1954. |
Safety Profile
An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NOx, Na2O, and SOx.
Specification
Acetazolamide sodium (CAS NO.1424-27-7) is a high-toxic material, flammable,thermal decomposition would release highly toxic nitrogen oxides, sulfur oxides and sodium oxide fumes,it should be stored in low temperature, ventilation, drying environmental conditions,separated with food and raw materials, besides water, carbon oxides and oxidation of toxic carbon dioxide, dry powder, sand, water mist fire extinguishing agent can be used if emergency.