Products Categories
| CAS No.: | 5508-58-7 |
|---|---|
| Name: | Andrographolide |
| Molecular Structure: | |
|
|
|
| Formula: | C20H30O5 |
| Molecular Weight: | 350.45 |
| Synonyms: | 2(3H)-Furanone, 3-[2-[(1R,4aS,5R,6R,8aS)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-, (3E,4S)-;2(3H)-Furanone, 3-(2-(decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl)ethylidene)dihydro-4-hydroxy-, (1R-(1-alpha(E(S*)),4a-beta,5-alpha,6-alpha,8a-alpha))-;(3E)-3-[2-[(1S,8aR)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-decalin-1-yl]ethylidene]-4-hydroxy-oxolan-2-one;Andrographis; |
| EINECS: | 226-852-5 |
| Density: | 1.21 g/cm3 |
| Melting Point: | 229-232 °C(lit.) |
| Boiling Point: | 557.3 °C at 760 mmHg |
| Flash Point: | 195.5 °C |
| Appearance: | powder |
| Hazard Symbols: |
 Xn
|
| Risk Codes: | 20/21/22-36/37/38 |
| Safety: | 22-24/25-36-26 |
| PSA: | 86.99000 |
| LogP: | 1.96260 |
- 81281-59-67-Benzylideneaminotheophylline
- 82993-81-5D-threo-Ritalinic acid hydrochloride
- 73441-42-6METHYL-5-CHLORO-2,2-DIMETHYLVALERATE
- 68439-39-4Poly(oxy-1,2-ethanediyl), alpha-(2-ethylhexyl)-omega-hydroxy-,
- 852475-26-4MC1568
- 958254-66-51H-Imidazo[4,5-b]pyridine-2-carboxaldehyde, 1-methyl-, hydrochloride
- 99170-93-1N-Methyl-2-oxazolamine
- 717878-06-31-(4-fluorophenyl)-4-nitro-1H-imidazole
- 914458-26-7[5-(2-fluorophenyl)-1-pentyl-1H-pyrrol-3-yl]-1-naphthalenyl-Methanone
- 894852-01-87-BROMO-2,2-DIMETHYL-2H-PYRIDO[3,2-B][1,4]OXAZIN-3(4H)-ONE
- 108-24-7
acetic anhydride
- 5508-58-7
andrographolide
- 79233-05-9
ent-(14Ξ)-3β,14,19-triacetoxy-15-hydroxy-labda-8(20),12ξ-dien-16-oic acid-lactone
| Conditions | Yield |
|---|---|
| With zinc(II) chloride | |
| With sulfuric acid |
- 5508-58-7
andrographolide
| Conditions | Yield |
|---|---|
| With ethanol; platinum Hydrogenation; |
| Conditions | Yield |
|---|---|
| With hydrogenchloride |
- 5508-58-7
andrographolide
| Conditions | Yield |
|---|---|
| With hydrogenchloride; acetic acid |
| Conditions | Yield |
|---|---|
| at 320℃; |
What can I do for you?
Get Best Price
Chemistry
Molecular Structure of Andrographis (CAS NO.5508-58-7):
.png)
IUPAC Name: (3E,4S)-3-[2-[(1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethylidene]-4-hydroxyoxolan-2-one
Empirical Formula: C20H30O5
Molecular Weight: 350.4492
H bond acceptors: 5
H bond donors: 3
Freely Rotating Bonds: 6
Polar Surface Area: 53.99 Å2
Index of Refraction: 1.567
Molar Refractivity: 94.13 cm3
Molar Volume: 287.9 cm3
Surface Tension: 51.9 dyne/cm
Density: 1.21 g/cm3
Flash Point: 195.5 °C
Enthalpy of Vaporization: 96.43 kJ/mol
Boiling Point: 557.3 °C at 760 mmHg
Vapour Pressure: 9.64E-15 mmHg at 25°C
Melting point: 229-232 °C(lit.)
alpha: -126 o (c=1.5,HAc)
Merck: 13,638
EINECS: 226-852-5
InChI
InChI=1/C20H30O5/c1-12-4-7-16-19(2,9-8-17(23)20(16,3)11-21)14(12)6-5-13-15(22)10-25-18(13)24/h5,14-17,21-23H,1,4,6-11H2,2-3H3/b13-5+/t14-,15?,16?,17?,19+,20?/m1/s1
Smiles
C1[C@@H]([C@@]([C@@H]2CCC(=C)[C@H](C\C=C3\C(OC[C@@H]3O)=O)[C@@]2(C)C1)(C)CO)O
Product Categories: Di-Terpenoids; Asymmetric Synthesis; Chiral Building Blocks; Complex Molecules
Production
Andrographis (CAS NO.5508-58-7) is derived from the leaves of a lactone.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 11460mg/kg (11460mg/kg) | Indian Journal of Medical Research. Vol. 92, Pg. 276, 1990. |
Safety Profile
Hazard Codes: 
Xn
Risk Statements: 20/21/22-36/37/38
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 22-24/25-36-26
S22:Do not breathe dust.
S24/25:Avoid contact with skin and eyes.
S36:Wear suitable protective clothing.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
RTECS: LU3490750
Standards and Recommendations
Substance: Andrographis Paniculata
Content (%) of Madecassic acid: 100%
Specification
Andrographis , with CAS number of 5508-58-7, can be called 2(3H)-Furanone, 3-[2-[(1R,4aS,5R,6R,8aS)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-, (3E,4S)- ; Madecassic acid ; 2(3H)-Furanone, 3-(2-(decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl)ethylidene)dihydro-4-hydroxy-, (1R-(1-alpha(E(S*)),4a-beta,5-alpha,6-alpha,8a-alpha))- ; 3-[2-[decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenenaphthyl]ethylidene]dihydro-4-hydroxyfuran-2(3H)-one ; (3E,4S)-3-[2-[(1S,4aS,5R,6R,8aR)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-decalin-1-yl]ethylidene]-4-hydroxy-oxolan-2-one . It is antibacterial and anti-inflammatory. The application of Andrographis (CAS NO.5508-58-7) in the treatment of bacterial dysentery, acute gastroenteritis, mumps, tonsillitis, laryngitis, upper respiratory tract infection infections.