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| CAS No.: | 4474-91-3 |
|---|---|
| Name: | ANGIOTENSIN II, HUMAN |
| Molecular Structure: | |
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| Formula: | C50H71N13O12 |
| Molecular Weight: | 1046.19 |
| Synonyms: | Angiotensin II, human (Octapeptide);Alanine,N-[1-[N-[N-[N-[N-(N2-L-a-aspartyl-L-arginyl)-L-valyl]-L-tyrosyl]-L-isoleucyl]-L-histidyl]-L-prolyl]-3-phenyl-,L- (6CI,7CI); |
| EINECS: | 2017-001-1 |
| Density: | 1.43 g/cm3 |
| Boiling Point: | 809.08°C (rough estimate) |
| Solubility: | Soluble in Water (25 mg/ml), and 5% Acetic Acid (1 mg/ml). |
| PSA: | 406.34000 |
| LogP: | 3.06950 |
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Chemistry
Molecular Structure:
Molecular Formula: C50H71N13O12
Molecular Weight: 1046.1786
IUPAC Name: (3S)-3-Amino-4-[[(2S)-5-(diaminomethylideneamino)-1-[[(2R)-1-[[(2S)-1-[[(3S)-1-[[(2S)-1-[(2S)-2-[[(2S)-1-hydroxy-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopentan-2-yl]amino]-4-oxobutanoic acid
Synonyms of Angiotensin II, human (CAS NO.4474-91-3): Angiotensin II, ile(5)- ; Angiotensin ii [INN:JAN] ; 5-Isoleucine-angiotensin II ; 5-L-Isoleucineangiotensin II ; Angiotensin II (human) ; Angiotensin II (mouse) ; Angiotensin ii ; Human angiotensin II ; Isoleucine5-angiotensin II ; L-Phenylalanine, N-(1-(N-(N-(N-(N-(N2-L-alpha-aspartyl-L-arginyl)-L-valyl)-L-tyrosyl)-L-isoleucyl)-L-histidyl)-L-prolyl)- ; 5-L-Isoleucineangiotensin II ; Alanine, N-(1-(N-(N-(N-(N-(N2-L-alpha-aspartyl-L-arginyl)-L-valyl)-L-tyrosyl)-L-isoleucyl)-L-histidyl)-L-prolyl)-3-phenyl-, L- ; Angiotensin II, 5-L-isoleucine-
CAS NO: 4474-91-3
Classification Code: Reproductive Effect
Index of Refraction: 1.663
Molar Refractivity: 269.46 cm3
Molar Volume: 726.8 cm3
Surface Tension: 61.6 dyne/cm
Density: 1.43 g/cm3
Uses
Angiotensin II, human (CAS NO.4474-91-3) is used in biochemical and medical research ,it is blood pressure medicine. Used for post-traumatic or surgical shock, or spinal anesthesia-induced hypotension.
Production
Raw materials :Sodium bicarbonate-->Dicyclohexylcarbodiimide-->Citric acid monohydrate-->L-Histidine-->Phenprobamate-->Octanoic hydrazide-->Angiotensin
Cbz-Phe-tert-butyl and the corresponding protected amino acids monomers as raw materials, using solid-phase synthesis, then Angiotensin II, human (CAS NO.4474-91-3) is derived .
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intravenous | 30800ug/kg (30.8mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 6079, 1990. | |
| rat | LD50 | intravenous | 17400ug/kg (17.4mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 6079, 1990. |
Safety Profile
A poison by intravenous route. Experimental reproductive effects. When heated to decomposition it emits toxic vapors of NOx.
WGK Germany of Angiotensin II, human (CAS NO.4474-91-3): 3
Specification
Adverse reactions and contraindications: sometimes can cause dizziness, headache, even induced angina pectoris. Overdose can cause bradycardia. Cardiac dysfunction with caution.