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Antazoline

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Name

Antazoline

EINECS 202-094-0
CAS No. 91-75-8 Density 1.1 g/cm3
PSA 27.63000 LogP 2.45930
Solubility 663.4mg/L(30 oC) Melting Point 159oC
Formula C17H19N3 Boiling Point 475.5 °C at 760 mmHg
Molecular Weight 265.358 Flash Point 241.4 °C
Transport Information N/A Appearance Crystals. Odorless.
Safety Risk Codes N/A
Molecular Structure Molecular Structure of 91-75-8 (Antazoline) Hazard Symbols N/A
Synonyms

2-Imidazoline,2-[(N-benzylanilino)methyl]- (8CI);2-[(N-Benzylanilino)methyl]-2-imidazoline;Allergan A;Antistine;Phenazoline;

Article Data 8

Antazoline Chemical Properties

Phenazoline is also named as Antazoline;1H-Imidazole-2-methanamine, 4,5-dihydro-N-phenyl-N-(phenylmethyl)-;2-(N-Phenyl-N-benzylaminomethyl)imidazoline;2-[(N-Benzylanilino)methyl]-2-imidazol;2-[(N-Benzylanilino)methyl]-2-imidazoline;2-Imidazoline, 2-[(N-benzylanilino)methyl]-;2-Phenyl-benzyl-amino-methylimidazolin;4,5-Dihydro-N-phenyl-N-phenylmethyl-1H-imidazole-2-methanamine,and so on.

Molecular Formula: C17H19N3
Molecular Weight: 265.35
EINECS: 202-094-0
Appearance:Crystals. Odorless.
Solubility in water:Insoluble
Melting Point:159 °C
Boiling Point:210 - 220 °C (0.7 torr)
Density:1.188 g/cm3

Antazoline Uses

Phenazoline is the 1st generation antihistamine used to relieve nasal congestion and in eye drops,and it can be used to relieve the symptoms of allergic.

Antazoline Toxicity Data With Reference

1.   

eye-rbt 1%

   OPHTAD    Ophtalmologica. 143 (1962),154.
2.   

orl-mus LD50:398 mg/kg

   ARZNAD    Arzneimittel-Forschung. Drug Research. 7 (1957),237.
3.   

ipr-mus LD50:100 mg/kg

   AEPPAE    Naunyn-Schmiedeberg’s Archiv fuer Experimentelle Pathologie und Pharmakologie. 237 (1959),171.
4.   

scu-mus LD50:135 mg/kg

   ARZNAD    Arzneimittel-Forschung. Drug Research. 17 (1967),214.

RTECS:  NJ2000000

Antazoline Safety Profile

Poison by ingestion, subcutaneous, and intraperitoneal routes. An eye irritant. When heated to decomposition it emits toxic fumes of NOx.

Hazardous Substances Data: 91-75-8(Hazardous Substances Data)

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